Showing papers by "Kent State University published in 2008"

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

Abstract: Background Evidence-based medicine is valuable to the extent that the evidence base is complete and unbiased. Selective publication of clinical trials — and the outcomes within those trials — can lead to unrealistic estimates of drug effectiveness and alter the apparent risk–benefit ratio. Methods We obtained reviews from the Food and Drug Administration (FDA) for studies of 12 antidepressant agents involving 12,564 patients. We conducted a systematic literature search to identify matching publications. For trials that were reported in the literature, we compared the published outcomes with the FDA outcomes. We also compared the effect size derived from the published reports with the effect size derived from the entire FDA data set. Results Among 74 FDA-registered studies, 31%, accounting for 3449 study participants, were not published. Whether and how the studies were published were associated with the study outcome. A total of 37 studies viewed by the FDA as having positive results were published; 1 stu...

Developing a community of inquiry instrument : Testing a measure of the Community of Inquiry framework using a multi-institutional sample

Abstract: This article reports on the multi-institutional development and validation of an instrument that attempts to operationalize Garrison, Anderson and Archer's Community of Inquiry (Col) framework (2000). The results of the study suggest that the instrument is a valid, reliable, and efficient measure of the dimensions of social presence and cognitive presence, thereby providing additional support for the validity of the Col as a framework for constructing effective online learning environments. While factor analysis supported the idea of teaching presence as a construct, it also suggested that the construct consisted of two factors-one related to course design and organization and the other related to instructor behavior during the course. The article concludes with a discussion of potential implications of further refinement of the Col measures for researchers, designers, administrators, and instructors.

Aesthetics and credibility in web site design

Abstract: Web sites often provide the first impression of an organization. For many organizations, web sites are crucial to ensure sales or to procure services within. When a person opens a web site, the first impression is probably made in a few seconds, and the user will either stay or move on to the next site on the basis of many factors. One of the factors that may influence users to stay or go is the page aesthetics. Another reason may involve a user's judgment about the site's credibility. This study explores the possible link between page aesthetics and a user's judgment of the site's credibility. Our findings indicate that when the same content is presented using different levels of aesthetic treatment, the content with a higher aesthetic treatment was judged as having higher credibility. We call this the amelioration effect of visual design and aesthetics on content credibility. Our study suggests that this effect is operational within the first few seconds in which a user views a web page. Given the same content, a higher aesthetic treatment will increase perceived credibility.

Eating Disorder Examination Questionnaire (EDE-Q): norms for undergraduate women.

Abstract: Objective: This research presents normative data on the Eating Disorder Examination Questionnaire (Fairburn and Beglin, Int J Eat Disorder, 16, 363-370, 1994) (EDE-Q) for samples of undergraduate women in the United States. Method: College women (N 5 723), ages 18–25, completed the EDE-Q as part of a larger assessment battery. Results: Average scores, standard deviations, and percentile ranks for the raw Restraint, Eating Concern, Shape Concern, and Weight Concern subscales and the Global score are reported. Data on the occurrence of objective and subjective bulimic episodes and compensatory behaviors are presented. Conclusion: These results are helpful for clinicians and researchers in the interpretation of the EDE-Q scores of undergraduate women in the United States. Comparisons are drawnbetween the results for this sample and those of a United Kingdom sample of young adolescent females, an Australian community sample, and an Australian community age-matched sample. V C 2008

Ordered mesoporous alumina-supported metal oxides

Abstract: The one-pot synthesis of alumina-supported metal oxides via self-assembly of a metal precursor and aluminum isopropoxide in the presence of triblock copolymer (as a structure directing agent) is described in detail for nickel oxide. The resulting mesoporous mixed metal oxides possess p6 mm hexagonal symmetry, well-developed mesoporosity, relatively high BET surface area, large pore widths, and crystalline pore walls. In comparison to pure alumina, nickel aluminum oxide samples exhibited larger mesopores and improved thermal stability. Also, long-range ordering of the aforementioned samples was observed for nickel molar percentages as high as 20%. The generality of the recipe used for the synthesis of mesoporous nickel aluminum oxide was demonstrated by preparation of other alumina-supported metal oxides such as MgO, CaO, TiO 2, and Cr 2O 3. This method represents an important step toward the facile and reproducible synthesis of ordered mesoporous alumina-supported materials for various applications where large and accessible pores with high loading of catalytically active metal oxides are needed.

Probing Cold Dense Nuclear Matter

Abstract: The protons and neutrons in a nucleus can form strongly correlated nucleon pairs. Scattering experiments, in which a proton is knocked out of the nucleus with high-momentum transfer and high missing momentum, show that in carbon-12 the neutron-proton pairs are nearly 20 times as prevalent as proton-proton pairs and, by inference, neutron-neutron pairs. This difference between the types of pairs is due to the nature of the strong force and has implications for understanding cold dense nuclear systems such as neutron stars.

Social Determinants of Black-White Disparities in Breast Cancer Mortality: A Review

Abstract: Despite the recent decline in breast cancer mortality, African American women continue to die from breast cancer at higher rates than do White women. Beyond the fact that breast cancer tends to be a more biologically aggressive disease in African American than in White women, this disparity in breast cancer mortality also reflects social barriers that disproportionately affect African American women. These barriers hinder cancer prevention and control efforts and modify the biological expression of disease. The present review focuses on delineating social, economic, and cultural factors that are potentially responsible for Black-White disparities in breast cancer mortality. This review was guided by the social determinants of health disparities model, a model that identifies barriers associated with poverty, culture, and social injustice as major causes of health disparities. These barriers, in concert with genetic, biological, and environmental factors, can promote differential outcomes for African American and White women along the entire breast cancer continuum, from screening and early detection to treatment and survival. Barriers related to poverty include lack of a primary care physician, inadequate health insurance, and poor access to health care. Barriers related to culture include perceived invulnerability, folk beliefs, and a general mistrust of the health care system. Barriers related to social injustice include racial profiling and discrimination. Many of these barriers are potentially modifiable. Thus, in addition to biomedical advancements, future efforts to reduce disparities in breast cancer mortality should address social barriers that perpetuate disparities among African American and White women in the United States.

A 1,000-year sediment record of tsunami recurrence in northern Sumatra

Abstract: Nothing known from written history gave reason to expect the Indian Ocean tsunami that took nearly a quarter million lives on 26 December 2004. That tsunami entered geological history by laying down centimetres of sand on the coastal plains that it overran. Jankaew et al. have now found such sedimentary records of earlier tsunamis preserved in the dark soils of marshy swales at Phra Thong, a barrier island in western Thailand. The cover shows an example from a pit dug there in 2007: the topmost light-coloured layer represents the 2004 tsunami, while a similar layer below records a tsunami in the fourteenth or fifteenth century AD. The ruler divisions are 10 cm long. In a separate study in Aceh, Indonesia, Monecke et al. found the 2004 sand sheet preceded by the deposits of three tsunamis from the past 1,200 years. One of these earlier deposits may match the medieval one found in Thailand. The combined findings suggest that the 2004 tsunami is neither the first nor the last of its kind. The Indian Ocean tsunami of 26 December 2004 reached maximum wave heights of 35 m in Aceh, the northernmost province of Sumatra1,2. Both the tsunami and the associated Sumatra–Andaman earthquake were unprecedented in Acehnese history3,4. Here we use sand sheets to extend tsunami history 1,000 years into Aceh’s past. The 2004 tsunami deposited a sand sheet up to 1.8 km inland on a marshy beach ridge plain. Sediment cores from these coastal marshes revealed two older extensive sand sheets with similar sediment characteristics. These sheets, deposited soon after ad 1290–1400 and ad 780–990, probably resulted from earlier tsunamis. An additional sand sheet of limited extent might correlate with a documented smaller tsunami of ad 1907. These findings, a first step towards a palaeotsunami record for northern Sumatra, suggest that damage-causing tsunamis in Aceh recur infrequently enough for entire human lifetimes to typically elapse between them. Such recurrence adds to the challenge of preparing communities along the northern Indian Ocean shorelines for future tsunamis.

Searching for and finding meaning in collective trauma: results from a national longitudinal study of the 9/11 terrorist attacks.

Abstract: The ability to make sense of events in one's life has held a central role in theories of adaptation to adversity. However, there are few rigorous studies on the role of meaning in adjustment, and those that have been conducted have focused predominantly on direct personal trauma. The authors examined the predictors and long-term consequences of Americans' searching for and finding meaning in a widespread cultural upheaval--the terrorist attacks of September 11, 2001--among a national probability sample of U.S. adults (N=931). Searching for meaning at 2 months post-9/11 was predicted by demographics and high acute stress response. In contrast, finding meaning was predicted primarily by demographics and specific early coping strategies. Whereas searching for meaning predicted greater posttraumatic stress (PTS) symptoms across the following 2 years, finding meaning predicted lower PTS symptoms, even after controlling for pre-9/11 mental health, exposure to 9/11, and acute stress response. Mediation analyses suggest that finding meaning supported adjustment by reducing fears of future terrorism. Results highlight the role of meaning in adjustment following collective traumas that shatter people's fundamental assumptions about security and invulnerability.

Using Computer-Presented Social Stories and Video Models to Increase the Social Communication Skills of Children with High-Functioning Autism Spectrum Disorders.

Abstract: The purpose of this study was to investigate the effects of computer-presented Social Stories and video models on the social communication skills of three children with High-Functioning Autism/Aspe...

Corporate Board Governance and Voluntary Disclosure of Executive Compensation Practices

Abstract: This study examines how corporate boards respond to investor demands for information on executive compensation practices and whether certain board and compensation committee characteristics, as proxies for board governance quality, are associated with the extent of board disclosure of compensation practices. A unique feature of this study is the development of a comprehensive checklist of 23 compensation-related items. I validate this index by showing that the disclosure scores are inversely related to two measures of information asymmetry: bid-ask spread and return volatility. This provides evidence that greater compensation disclosure reduces information asymmetry. The study presents some evidence that boards with the power to act independently from management provide more details about executive compensation practices. Moreover, it contributes to the literature on corporate governance and disclosure by showing that greater commitment of directors to perform their duties results in greater transparency.

Development and examination of the social appearance anxiety scale.

Abstract: The Social Appearance Anxiety Scale (SAAS) was created to measure anxiety about being negatively evaluated by others because of one's overall appearance, including body shape. This study examined the psychometric properties of the SAAS in three large samples of undergraduate students (respective ns = 512, 853, and 541). The SAAS demonstrated a unifactorial structure with high test-retest reliability and internal consistency. The SAAS was positively associated with measures of social anxiety. The SAAS was also related to greater disparity between perceived, actual, and ideal physical attributes, beliefs that one's appearance is inherently flawed and socially unacceptable and that being unattractive is socially deleterious, feelings of unattractiveness, emphasis on appearance and its maintenance, and a preoccupation with being overweight. It was a unique predictor of social anxiety above and beyond negative body image indicators. Findings suggest that the SAAS is a psychometrically valid measure of social anxiety regarding one's overall appearance.

Notes on A∞-Algebras, A∞-Categories and Non-Commutative Geometry

Abstract: We develop a geometric approach to A-infinity algebras and A-infinity categories based on the notion of formal scheme in the category of graded vector spaces. The geometric approach clarifies several questions, e.g. the notion of homological unit or A-infinity structure on A-infinity functors. We discuss Hochschild complexes of A-infinity algebras from the geometric point of view. The chapter contains homological versions of the notions of properness and smoothness of projective varieties as well as the non-commutative version of the Hodge-to-de Rham degeneration conjecture. We also discuss a generalization of Deligne’s conjecture which includes both Hochschild chains and cochains. We conclude the chapter with the description of an action of the PROP of singular chains of the topological PROP of two-dimensional surfaces on the Hochschild chain complex of an A-infinity algebra with scalar product (this action is more or less equivalent to the structure of two-dimensional Topological Field Theory associated with an “abstract” Calabi–Yau manifold).

Asymmetric Information and Dividend Policy

Abstract: We examine how informational asymmetries affect firms’ dividend policies. We find that firms that are more subject to information asymmetry are less likely to pay, initiate, or increase dividends, and disburse smaller amounts. We show that our main results are not driven by our sample and that our results persist after accounting for the changing composition of payout over the sample period, the increasing importance of institutional shareholdings, and catering incentives. We conclude that there is a negative relation between asymmetric information and dividend policy. Our results do not support the signaling theory of dividends. Inthis paper, we study how informational asymmetries affect firms’ dividend policies by examining the relation between a firm’s dividend policy and the quality of its information environment. Dividends have long puzzled financial economists. Miller and Modigliani (1961) prove that dividend policy is irrelevant to share value in a perfect and efficient capital market. However, the observation that share prices typically rise when firms increase dividend payments suggests that, on the contrary, dividends do matter after all. Various studies have proposed various explanations for firms’ dividend behavior (see Allen and Michaely, 2003, for a comprehensive review of the literature). Among them, the dividend signaling theory is one of the dominant explanations. Under the signaling models of Bhattacharya (1979), John and Williams (1985), and Miller and Rock (1985), managers know more about the firm’s true worth than do its investors and use dividends to convey information to the market. Thus, these models suggest a positive relation between information asymmetry and dividend policy. Other studies have developed tests to examine the dividend signaling models. However, our study may be the first to specifically examine the testable implications of the signaling models in the context of the relation between information asymmetry and firms’ dividend policies. To conduct our research, we ask the following questions: Are corporate dividend policies affected by the degree of information asymmetry that firms face? Is the relation consistent with the signaling view of asymmetric information? Given that information asymmetry is a

Heavy-ion collisions at the LHC-Last call for predictions

Abstract: This writeup is a compilation of the predictions for the forthcoming Heavy Ion Program at the Large Hadron Collider, as presented at the CERN Theory Institute 'Heavy Ion Collisions at the LHC - Last Call for Predictions', held from 14th May to 10th June 2007.

Relationship between body mass index and brain volume in healthy adults.

Abstract: There is a growing evidence that elevated body mass index (BMI) is associated with adverse neurocognitive outcome, though no study has examined whether morphometric differences are found in persons across the adult life span. We compared 201 healthy individuals in normal weight, overweight, and obese groups (aged 17-79). After correcting for demographic differences, obese individuals showed smaller whole brain and total gray matter volume than normal weight and overweight individuals. These findings support an independent relationship between BMI and brain structure and demonstrate that these differences are not limited to older adults.

The Compassion Fatigue Scale: Its Use With Social Workers Following Urban Disaster

Abstract: Objective: The present study has two goals: to assess the difference between secondary trauma and job burnout and to examine the utility of secondary trauma in predicting psychological distress. Method: The data come from a survey of social workers (N = 236) living in New York City 20 months following the September 11 terrorist attacks on the World Trade Center (WTC). Results: Social workers'involvement in WTC recovery efforts is related to secondary trauma but not burnout. Analyses also reveal that both secondary trauma and burnout are related to psychological distress after controlling for other risk factors. Conclusion: This study supports the importance of compassion fatigue as a risk factor for social workers counseling traumatized clients and its association with psychological problems.

The association of exposure, risk, and resiliency factors with PTSD among Jews and Arabs exposed to repeated acts of terrorism in Israel

Abstract: Israel has faced ongoing terrorism since the beginning of the Al Aqsa Intifada in September 2000. The authors examined risk and resiliency factors associated with posttraumatic stress disorder (PTSD) among 1,117 Jews and 394 Arab adult citizens of Israel during August and September 2004 through telephone interviews. Probable PTSD was found among 6.6% of Jews and 18.0% of Arabs. Predictors of probable PTSD in a multivariate model for Jews were refusal to report income, being traditionally religious, economic and psychosocial resource loss, greater traumatic growth, and lower social support. For Arabs, predictors were low education and economic resource loss among those exposed to terrorism. Findings for only those directly exposed to terrorism were similar to those for the overall national sample.

Global diversity of large branchiopods (Crustacea: Branchiopoda) in freshwater

Abstract: With about 500 known species worldwide, the large brachiopods are a relatively small group of primitive crustaceans. With few exceptions they live in temporary aquatic systems that are most abundant in arid and semi arid areas. As many regions remain unexplored and as especially the number of species in clam shrimps and tadpole shrimps is underestimated due to difficult identification, the species list will increase with future surveys. The Branchiopoda are monophyletic, but inter-ordinal relationships, as well as many evolutionary relationships at lower taxonomic levels are still unclear. Ongoing molecular studies will more accurately depict species diversity and phylogenetic patterns. With the exception of some anostracan families, most families are not restricted to the northern or southern hemisphere or specific zoogeographical regions. Large branchiopods are used for the assessment of the quality and function of temporary wetlands. Due to the reduction in number and quality of temporary wetlands, several species became endangered and are red listed by the IUCN.

Centrality dependence of charged hadron and strange hadron elliptic flow from √SNN = 200 GeV Au+Au collisions

Abstract: We present STAR results on the elliptic flow upsilon(2) Of charged hadrons, strange and multistrange particles from,root s(NN) = 200 GeV Au+Au collisions at the BNL Relativistic Heavy Ion Collider (RHIC). The detailed study of the centrality dependence of upsilon(2) over a broad transverse momentum range is presented. Comparisons of different analysis methods are made in order to estimate systematic uncertainties. To discuss the nonflow effect, we have performed the first analysis Of upsilon(2) with the Lee-Yang zero method for K(S)(0) and A. In the relatively low PT region, P(T) <= 2 GeV/c, a scaling with m(T) - m is observed for identified hadrons in each centrality bin studied. However, we do not observe nu 2(p(T))) scaled by the participant eccentricity to be independent of centrality. At higher PT, 2 1 <= PT <= 6 GeV/c, V2 scales with quark number for all hadrons studied. For the multistrange hadron Omega, which does not suffer appreciable hadronic interactions, the values of upsilon(2) are consistent with both m(T) - m scaling at low p(T) and number-of-quark scaling at intermediate p(T). As a function ofcollision centrality, an increase of p(T)-integrated upsilon(2) scaled by the participant eccentricity has been observed, indicating a stronger collective flow in more central Au+Au collisions.

A photoactivatable push-pull fluorophore for single-molecule imaging in live cells.

Abstract: We have reengineered a red-emitting dicyanomethylenedihydrofuran push-pull fluorophore so that it is dark until photoactivated with a short burst of low-intensity violet light. Photoactivation of the dark fluorogen leads to conversion of an azide to an amine, which shifts the absorption to long wavelengths. After photoactivation, the fluorophore is bright and photostable enough to be imaged on the single-molecule level in living cells. This proof-of-principle demonstration provides a new class of bright photoactivatable fluorophores, as are needed for super-resolution imaging schemes that require active control of single molecule emission.

Exploring the factors related to acceptance of evolutionary theory among Turkish preservice biology teachers: Toward a more informative conceptual ecology for biological evolution

Abstract: In this study, using multiple regression analysis, we aimed to explore the factors related to acceptance of evolutionary theory among preservice Turkish biology teachers using conceptual ecology for biological evolution as a theoretical lens. We aimed to determine the extent to which we can account for the variance in acceptance of evolutionary theory by using understanding of evolutionary theory, epistemological beliefs, thinking dispositions, and parents' educational level as independent variables. Preservice biology teachers' thinking dispositions, their understanding of evolutionary theory, and their parents' educational level are positively correlated with acceptance of evolutionary theory. We did not find any significant positive correlation between epistemological beliefs and acceptance of evolution because of low reliability coefficients of subscales of the epistemological beliefs instrument. Together they explained 10.5% of the variance. These results suggest that studying the relationship between acceptance of evolutionary theory and other related factors in a multivariate context is more informative than examining the relationship between acceptance of evolutionary theory and other factors in isolation. Our findings indicate that studying a controversial issue such as acceptance of evolutionary theory in a multivariate fashion, using conceptual ecology as a theoretical lens to interpret the findings, is informative. Our results suggest the inclusion of thinking dispositions in conceptual ecology for biological evolution. © 2007 Wiley Periodicals, Inc. J Res Sci Teach 45: 420–443, 2008

Geographic Diversification, Bank Holding Company Value, and Risk

Abstract: We assess the association between geographic diversification and bank holding company (BHC) value and risk, controlling for the distance between the headquarters and branches. The distance-adjusted deposit dispersion index used as a measure of geographic diversification accounts for the number of locations where a BHC operates, the level of activity in each location, and the distance between a BHC and its branches. We find that geographic diversification is associated with BHC value enhancement and risk reduction, increased distance between a BHC and its branches is associated with firm value reduction and risk increase, and geographic diversification across more remote areas is associated with greater value enhancement but smaller risk reduction.

Family-centred practice: collaboration, competency and evidence

Abstract: In the 1990s, the developing field of early intervention with young children with disabilities and their families adopted family-centred practice as its philosophical foundation. Family-centred practice includes three key elements: (1) an emphasis on strengths, not deficits; (2) promoting family choice and control over desired resources; and (3) the development of a collaborative relationship between parents and professionals. During the last two decades, the field of early childhood disability has successfully defined the working principles of family-centred practice for practitioners. Although research has acknowledged that the paradigm shift to family-centred practice is neither simple nor easy, a substantive body of evidence demonstrates that (a) family-centred practice can be linked to a wide range of demonstrated benefits for both children and families, and (b) families are more satisfied and find family-centred practice to be more helpful than other models of practice.

Efficiently answering reachability queries on very large directed graphs

Abstract: Efficiently processing queries against very large graphs is an important research topic largely driven by emerging real world applications, as diverse as XML databases, GIS, web mining, social network analysis, ontologies, and bioinformatics. In particular, graph reachability has attracted a lot of research attention as reachability queries are not only common on graph databases, but they also serve as fundamental operations for many other graph queries. The main idea behind answering reachability queries in graphs is to build indices based on reachability labels. Essentially, each vertex in the graph is assigned with certain labels such that the reachability between any two vertices can be determined by their labels. Several approaches have been proposed for building these reachability labels; among them are interval labeling (tree cover) and 2-hop labeling. However, due to the large number of vertices in many real world graphs (some graphs can easily contain millions of vertices), the computational cost and (index) size of the labels using existing methods would prove too expensive to be practical. In this paper, we introduce a novel graph structure, referred to as path-tree, to help labeling very large graphs. The path-tree cover is a spanning subgraph of G in a tree shape. We demonstrate both analytically and empirically the effectiveness of our new approaches.