Institution
Kent State University
Education•Kent, Ohio, United States•
About: Kent State University is a education organization based out in Kent, Ohio, United States. It is known for research contribution in the topics: Liquid crystal & Population. The organization has 10897 authors who have published 24607 publications receiving 720309 citations. The organization is also known as: Kent State & KSU.
Topics: Liquid crystal, Population, Poison control, Adsorption, Minnesota Multiphasic Personality Inventory
Papers published on a yearly basis
Papers
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TL;DR: The results suggest that the ISG-type induction of dACE2 in IFN-high conditions created by treatments, an inflammatory tumor microenvironment or viral co-infections is unlikely to increase the cellular entry of SARS-CoV-2 and promote infection.
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, utilizes angiotensin-converting enzyme 2 (ACE2) for entry into target cells. ACE2 has been proposed as an interferon-stimulated gene (ISG). Thus, interferon-induced variability in ACE2 expression levels could be important for susceptibility to COVID-19 or its outcomes. Here, we report the discovery of a novel, transcriptionally independent truncated isoform of ACE2, which we designate as deltaACE2 (dACE2). We demonstrate that dACE2, but not ACE2, is an ISG. In The Cancer Genome Atlas, the expression of dACE2 was enriched in squamous tumors of the respiratory, gastrointestinal and urogenital tracts. In vitro, dACE2, which lacks 356 amino-terminal amino acids, was non-functional in binding the SARS-CoV-2 spike protein and as a carboxypeptidase. Our results suggest that the ISG-type induction of dACE2 in IFN-high conditions created by treatments, an inflammatory tumor microenvironment or viral co-infections is unlikely to increase the cellular entry of SARS-CoV-2 and promote infection.
198 citations
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University of Wisconsin-Madison1, University of Minnesota2, University of California, Merced3, Drexel University4, University of Oregon5, Pennsylvania State University6, Kent State University7, North Dakota State University8, United States Geological Survey9, Lehigh University10, Umeå University11, University of Illinois at Urbana–Champaign12, University of Göttingen13, University of Arizona14, University of Chile15, Columbia University16, Academy of Natural Sciences of Drexel University17, Kyoto Prefectural University18
TL;DR: The Neotoma Paleoecology Database as mentioned in this paper is a community-curated data resource that supports interdisciplinary global change research by enabling broad-scale studies of taxon and community diversity, distr...
198 citations
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TL;DR: Three major relaxation processes that contribute to the observed dynamics in the picosecond to nanosecond time range are identified: 1), fluctuations of methyl groups; 2), fast picose Cond relaxation; and 3), a slow relaxation process.
198 citations
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TL;DR: This work suggests an unorthodox design concept to control and manipulate the dynamic behavior of soft active matter and opens the door for potential biosensing and biomedical applications.
Abstract: Significance We propose a class of active matter, the living liquid crystal (LLC), representing motile rod-shaped bacteria placed in water-based nontoxic liquid crystal. Long-range orientational order of the liquid crystal and the swimming activity of bacteria demonstrate a strong coupling that dramatically alters individual and collective bacterial dynamics. For example, swimming bacteria perturb the orientational order of the liquid crystal or even cause its local melting, making the flagella motion optically visible. Second, self-organized textures emerge from the initial uniform LLC alignment with a characteristic length controlled by a balance between bacteria activity and anisotropic viscoelasticity of liquid crystal. Third, the local liquid crystal orientation controls the direction of motion of bacteria. LLC can lead to valuable biosensoring and biomedical applications. Collective motion of self-propelled organisms or synthetic particles, often termed “active fluid,” has attracted enormous attention in the broad scientific community because of its fundamentally nonequilibrium nature. Energy input and interactions among the moving units and the medium lead to complex dynamics. Here, we introduce a class of active matter––living liquid crystals (LLCs)––that combines living swimming bacteria with a lyotropic liquid crystal. The physical properties of LLCs can be controlled by the amount of oxygen available to bacteria, by concentration of ingredients, or by temperature. Our studies reveal a wealth of intriguing dynamic phenomena, caused by the coupling between the activity-triggered flow and long-range orientational order of the medium. Among these are (i) nonlinear trajectories of bacterial motion guided by nonuniform director, (ii) local melting of the liquid crystal caused by the bacteria-produced shear flows, (iii) activity-triggered transition from a nonflowing uniform state into a flowing one-dimensional periodic pattern and its evolution into a turbulent array of topological defects, and (iv) birefringence-enabled visualization of microflow generated by the nanometers-thick bacterial flagella. Unlike their isotropic counterpart, the LLCs show collective dynamic effects at very low volume fraction of bacteria, on the order of 0.2%. Our work suggests an unorthodox design concept to control and manipulate the dynamic behavior of soft active matter and opens the door for potential biosensing and biomedical applications.
198 citations
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TL;DR: This paper investigated the effects of oil price shocks and economic policy uncertainty on the stock returns of oil and gas companies and found that an oil demand-side shock has a positive effect on the return of oil companies on average, whereas shocks to policy uncertainty have a negative effect on return.
197 citations
Authors
Showing all 11015 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Marco Costa | 146 | 1458 | 105096 |
Jong-Sung Yu | 124 | 1051 | 72637 |
Mietek Jaroniec | 123 | 571 | 79561 |
M. Cherney | 118 | 572 | 49933 |
Qiang Xu | 117 | 585 | 50151 |
Lee Stuart Barnby | 116 | 494 | 43490 |
Martin Knapp | 106 | 1067 | 48518 |
Christopher Shaw | 97 | 771 | 52181 |
B. V.K.S. Potukuchi | 96 | 190 | 30763 |
Vahram Haroutunian | 94 | 424 | 38954 |
W. E. Moerner | 92 | 478 | 35121 |
Luciano Rezzolla | 90 | 394 | 26159 |
Bruce A. Roe | 89 | 295 | 76365 |
Susan L. Brantley | 88 | 358 | 25582 |