Kent State University

About: Kent State University is a education organization based out in Kent, Ohio, United States. It is known for research contribution in the topics: Liquid crystal & Population. The organization has 10897 authors who have published 24607 publications receiving 720309 citations. The organization is also known as: Kent State & KSU.

Breast image registration techniques: a survey.

Abstract: Breast cancer is the most common type of cancer in women worldwide. Image registration plays an important role in breast cancer detection. This paper gives an overview of the current state-of-the-art in the breast image registration techniques. For the intra-modality registration techniques, X-ray, MRI, and ultrasound are the primary focuses of interest. Inter-modality techniques will cover the combination of different modalities. Validation of breast registration methods is also discussed.

HER-2 pulsed dendritic cell vaccine can eliminate HER-2 expression and impact ductal carcinoma in situ.

Abstract: BACKGROUND: HER-2/neu overexpression plays a critical role in breast cancer development, and its expression in ductal carcinoma in situ (DCIS) is associated with development of invasive breast cancer. A vaccine targeting HER-2/neu expression in DCIS may initiate immunity against invasive cancer. METHODS: A HER-2/neu dendritic cell vaccine was administered to 27 patients with HER-2/neu–overexpressing DCIS. The HER-2/neu vaccine was administered before surgical resection, and pre- and postvaccination analysis was conducted to assess clinical results. RESULTS: At surgery, 5 of 27 (18.5%) vaccinated subjects had no evidence of remaining disease, whereas among 22 subjects with residual DCIS, HER-2/neu expression was eradicated in 11 (50%). When comparing estrogen receptor (ER)neg with ERpos DCIS lesions, vaccination was more effective in hormone-independent DCIS. After vaccination, no residual DCIS was found in 40% of ERneg subjects compared with 5.9% in ERpos subjects. Sustained HER-2/neu expression was found in 10% of ERneg subjects compared with 47.1% in ERpos subjects (P = .04). Postvaccination phenotypes were significantly different between ERpos and ERneg subjects (P = .01), with 7 of 16 (43.8%) initially presenting with ERposHER-2/neupos luminal B phenotype finishing with the ERposHER-2/neuneg luminal A phenotype, and 3 of 6 (50%) with the ERnegHER-2/neupos phenotype changing to the ERnegHER-2/neuneg phenotype. CONCLUSIONS: Results suggest that vaccination against HER-2/neu is safe and well tolerated and induces decline and/or eradication of HER-2/neu expression. These findings warrant further exploration of HER-2/neu vaccination in estrogen-independent breast cancer and highlight the need to target additional tumor-associated antigens and pathways. Cancer 2012. © 2012 American Cancer Society.

Functionally distinct classes of complex phosphorus compounds in lake water1

Abstract: Abstmct Complex phosphorus compounds were classified functionally according to the manner by which orthophosphate was released. Filtrable phosphorus compounds in two cutrophic lakes (East and West Twin lakes) and a humic bog (Crazy Eddie Bog) in northeastern Ohio wcrc fractionated by anion-exchange and gel-filtration chromatography. Fractions were analyzed for soluble reactive phosphorus and total dissolved phosphorus; absorbance at 400 nm was used as a measure of filtrable “yellow acids.” The cutrophic lakes contained numerous low molecular weight compounds which were resistant to low-dose ultraviolet irradiation but readily released orthophosphate upon treatment with alkaline phosphatase. Filtrable phosphorus compounds of the humic bog were predominantly high molecular weight, cochromatographed with the yellow acids in each fractionation procedure, and resisted enzyme hydrolysis, but released orthophosphate upon irradiation with low doses of ultraviolet light.