Institution
Kettering University
Education•Flint, Michigan, United States•
About: Kettering University is a education organization based out in Flint, Michigan, United States. It is known for research contribution in the topics: RNA & Antigen. The organization has 6842 authors who have published 7689 publications receiving 337503 citations. The organization is also known as: GMI Engineering & Management Institute & General Motors Institute.
Topics: RNA, Antigen, DNA, Cancer, Population
Papers published on a yearly basis
Papers
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TL;DR: The structure and biochemical function of the hot dog-fold thioesterase PaaI operative in the aerobic phenylacetate degradation pathway are examined and a role in coenzyme A release from this pathway intermediate in the event of limiting downstream pathway enzymes is suggested.
108 citations
TL;DR: The relative analgesic potency of single graded intramuscular doses of methadone and morphine was evaluated in a double‐blind crossover study in patients with chronic pain due to cancer and methamphetamineadone was found to be approximately one half as potent orally as it was parenterally.
Abstract: The relative analgesic potency of single graded intramuscular doses of methadone and morphine was evaluated in a double‐blind crossover study in patients with chronic pain due to cancer. If one considered either \"total\" or \"peak\" effects, the analgesic potency of methadone was estimated to be equal to or slightly greater than that of morphine. The time‐effect curves of the two drugs were similar, and there was no evidence that methadone was longer acting than morphine. Oral and intramuscular methadone were compared in a similar patient group. In terms of \"total\" effect, methadone was found to be approximately one half as potent orally as it was parenterally, a relatively high ratio for oral activity as compared with other narcotics. In roughly equianalgesic doses, the occurrence of side effects was qualitatively and quantitatively similar for parenteral morphine and methadone and for oral and parenteral methadone.
108 citations
TL;DR: The data suggest that the mechanism of dietary fat induced growth of human prostate cancer cells is mediated by oxidative stress and raises the possibility of a therapeutic benefit of vitamin E in preventing prostate cancer.
107 citations
107 citations
TL;DR: The use of hydrodynamic cavitation in advanced oxidation processes (AOPs) to treat acidic effluents and process water has become a promising trend in the area of environmental protection as discussed by the authors.
107 citations
Authors
Showing all 6853 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Joan Massagué | 189 | 408 | 149951 |
| Chris Sander | 178 | 713 | 233287 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Murray F. Brennan | 161 | 925 | 97087 |
| Charles M. Rice | 154 | 561 | 83812 |
| Lloyd J. Old | 152 | 775 | 101377 |
| Howard I. Scher | 151 | 944 | 101737 |
| Paul Tempst | 148 | 309 | 89225 |
| Pier Paolo Pandolfi | 146 | 529 | 88334 |
| Barton F. Haynes | 144 | 911 | 79014 |
| Jedd D. Wolchok | 140 | 713 | 123336 |
| James P. Allison | 137 | 483 | 83336 |
| Harold E. Varmus | 137 | 496 | 76320 |
| Scott W. Lowe | 134 | 396 | 89376 |
| David S. Klimstra | 133 | 564 | 61682 |