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Institution

Khulna Medical College

HealthcareKhulna, Bangladesh
About: Khulna Medical College is a(n) healthcare organization based out in Khulna, Bangladesh. It is known for research contribution in the topic(s): Pregnancy & Hysterectomy. The organization has 266 authors who have published 203 publication(s) receiving 964 citation(s). The organization is also known as: Khulna Medical College, Khulna & KMC.


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Journal Article
H A M N Ahasan1, A A Mamun, S R Karim, M A Bakar, E A Gazi, C S Bala 
TL;DR: Since there is no specific treatment, people should be made aware of the potential risk of eating puffer fish, about the warning symptoms and signs of pufferFish poisoning, and when to seek medical help.
Abstract: Introduction: Puffer fish is available in Bangladesh and is occasionally eaten by some people. Ignorance regarding its proper cooking process may lead to serious health hazards, including fatality. Methods: An unusual catastrophic event happened recently in Khulna, Bangladesh that drew nationwide attention. Eight families were affected. Results: Thirty-seven patients were admitted with a history of consumption of puffer fish. Peri-oral paraesthesia (24), weakness of both lower limbs (22), paraesthesia all over the body (18), headache (15), difficulty in respiration (14), nausea and vomiting (8), blurring of vision (7), and vertigo (6) were common clinical presentations. Twentytwo patients developed ascending paralysis of limbs and involved the respiratory muscles in 17 patients. Eight patients died due to respiratory failure while the rest improved. Conclusion: Health personnel should have sufficient knowledge regarding the clinical manifestations, complications and management of puffer fish poisoning. During its preparation, organs that contain the highest level of tetrodotoxin should be removed. Since there is no specific treatment, people should be made aware of the potential risk of eating puffer fish, about the warning symptoms and signs of puffer fish poisoning, and when to seek medical help.

73 citations

Journal ArticleDOI
TL;DR: In a multicenter group of EBC patients, a model based on preoperative serum metabolomic profiles was developed that was prognostic for disease recurrence, independent of traditional clinicopathologic risk factors.
Abstract: Purpose: Detecting signals of micrometastatic disease in patients with early breast cancer (EBC) could improve risk stratification and allow better tailoring of adjuvant therapies. We previously showed that postoperative serum metabolomic profiles were predictive of relapse in a single-center cohort of estrogen receptor (ER)-negative EBC patients. Here, we investigated this further using preoperative serum samples from ER-positive, premenopausal women with EBC who were enrolled in an international phase III trial.Experimental Design: Proton nuclear magnetic resonance (NMR) spectroscopy of 590 EBC samples (319 with relapse or ≥6 years clinical follow-up) and 109 metastatic breast cancer (MBC) samples was performed. A Random Forest (RF) classification model was built using a training set of 85 EBC and all MBC samples. The model was then applied to a test set of 234 EBC samples, and a risk of recurrence score was generated on the basis of the likelihood of the sample being misclassified as metastatic.Results: In the training set, the RF model separated EBC from MBC with a discrimination accuracy of 84.9%. In the test set, the RF recurrence risk score correlated with relapse, with an AUC of 0.747 in ROC analysis. Accuracy was maximized at 71.3% (sensitivity, 70.8%; specificity, 71.4%). The model performed independently of age, tumor size, grade, HER2 status and nodal status, and also of Adjuvant! Online risk of relapse score.Conclusions: In a multicenter group of EBC patients, we developed a model based on preoperative serum metabolomic profiles that was prognostic for disease recurrence, independent of traditional clinicopathologic risk factors. Clin Cancer Res; 23(6); 1422-31. ©2017 AACR.

53 citations

Journal ArticleDOI
TL;DR: The incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial hygiene, and administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90%-100% survival.
Abstract: Anthrax is a zoonotic disease caused by Bacillus anthracis. It is potentially fatal and highly contagious disease. Herbivores are the natural host. Human acquire the disease incidentally by contact with infected animal or animal products. In the 18th century an epidemic destroyed approximately half of the sheep in Europe. In 1900 human inhalational anthrax occured sporadically in the United States. In 1979 an outbreak of human anthrax occured in Sverdlovsk of Soviet Union. Anthrax continued to represent a world wide presence. The incidence of the disease has decreased in developed countries as a result of vaccination and improved industrial hygiene. Human anthrax clinically presents in three forms, i.e. cutaneous, gastrointestinal and inhalational. About 95% of human anthrax is cutaneous and 5% is inhalational. Gastrointestinal anthrax is very rare (less than 1%). Inhalational form is used as a biological warefare agent. Penicillin, ciprofloxacin (and other quinolones), doxicyclin, ampicillin, imipenem, clindamycin, clarithromycin, vancomycin, chloramphenicol, rifampicin are effective antimicrobials. Antimicrobial therapy for 60 days is recommended. Human anthrax vaccine is available. Administration of anti-protective antigen (PA) antibody in combination with ciprofloxacin produced 90%-100% survival. The combination of CPG-adjuvanted anthrax vaccine adsorbed (AVA) plus dalbavancin significantly improved survival.

40 citations

Journal Article
TL;DR: ABO incompatibility is twice as common as Rh incompatibility and the majority of kernicterus patients died in the acute phase, according to this study.
Abstract: Background: Kernicterus occurs in infants around the world. This study examined the outcomes of various treatments for neonatal hyperbilirubinemia (NH) used in the Khulna Medical College Hospital in Bangladesh. Methods: All of the jaundiced newborns in the neonatal ward between 2005 and 2008 were included in the study. Total serum bilirubin and fractional levels were measured in all cases, regardless of the degree of jaundice. NH was classified as mild, moderate or severe depending on the bilirubin level; mild NH was treated with a sunbath, moderate NH was treated with phototherapy, and severe NH was treated with exchange transfusion. Results: Of 1981 neonates, 426 (22%) were diagnosed with NH. Physiological jaundice (26.7%) was most common, followed by the jaundice of prematurity (20.9%). Haemolytic jaundice was primarily caused by ABO incompatibility (11.3%) and Rh incompatibility (5.4%). Exchange transfusion (ET) was performed in 22 patients; four (18.2%) died as a result of hazards that could have been avoided with skilled monitoring. Twelve (2.8%) individuals with jaundice died. Kernicterus developed in nine (2.1%) children, four of whom survived with neurological sequelae. Conclusion: ABO incompatibility is twice as common as Rh incompatibility. The majority of kernicterus patients died in the acute phase.

33 citations

Journal ArticleDOI
07 Jun 2017
TL;DR: This Validated Bangla version of DASS 21 can be used to measure severity of depression among medical students and persons having similar academic background treatable.
Abstract: Standard scale to assess the symptoms of depression, anxiety and stress among MBBS students are essential to take necessary steps to treat or prevent any psychiatric morbidity. But there was no such convenient tool in Bangla to measure the stated symptoms. With an objective to obtain a convenient scale to measure severity of above symptoms, short version of Depression Anxiety Stress Scales (DASS 21) was translated into Bangla and the study was carried out to validate this Bangla version with permission from the author of the original instrument. Two translations and back translations were carried out. A harmonized version was produced after meetings by persons involved in translation process in meetings. After pretesting on ten students and reviewing by panel of experts, finalized Bangla version of DASS 21 (DASS 21 -BV) was obtained. A cross sectional study was carried out among MBBS students of Pabna Medical College, Pabna using purposive sampling technique to validate this scale. They were given both Bangla and English version of the scale 3 to 7 days apart. Analysis was done on 15 samples. Correlation for depression subscale was 0.976, anxiety subscale was 0.917 and stress subscale was 0.931. Correlation was significant at the 0.01 level (2-tailed). Cronbach’s Alpha for Depression, Anxiety and Stress subscales were 0.987, 0.957, 0.964 respectively. This Validated Bangla version of DASS 21 can be used to measure severity of depression among medical students and persons having similar academic background treatable. Bang J Psychiatry Dec 2014; 28(2): 67-70

28 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20217
202011
20193
201815
201724
201613