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Showing papers by "Khulna Medical College published in 2010"


Journal Article
TL;DR: ABO incompatibility is twice as common as Rh incompatibility and the majority of kernicterus patients died in the acute phase, according to this study.
Abstract: Background: Kernicterus occurs in infants around the world. This study examined the outcomes of various treatments for neonatal hyperbilirubinemia (NH) used in the Khulna Medical College Hospital in Bangladesh. Methods: All of the jaundiced newborns in the neonatal ward between 2005 and 2008 were included in the study. Total serum bilirubin and fractional levels were measured in all cases, regardless of the degree of jaundice. NH was classified as mild, moderate or severe depending on the bilirubin level; mild NH was treated with a sunbath, moderate NH was treated with phototherapy, and severe NH was treated with exchange transfusion. Results: Of 1981 neonates, 426 (22%) were diagnosed with NH. Physiological jaundice (26.7%) was most common, followed by the jaundice of prematurity (20.9%). Haemolytic jaundice was primarily caused by ABO incompatibility (11.3%) and Rh incompatibility (5.4%). Exchange transfusion (ET) was performed in 22 patients; four (18.2%) died as a result of hazards that could have been avoided with skilled monitoring. Twelve (2.8%) individuals with jaundice died. Kernicterus developed in nine (2.1%) children, four of whom survived with neurological sequelae. Conclusion: ABO incompatibility is twice as common as Rh incompatibility. The majority of kernicterus patients died in the acute phase.

36 citations


Journal ArticleDOI
TL;DR: Recombinant HB vaccine induces good level of protective immunity among vaccinated persons, and vaccinated individuals from lower socioeconomic condition have had comparatively low rate of protective antibody than people from middle and upper classes.
Abstract: Background: Hepatitis B virus infection is an important public health problem with significant morbidity and mortality. Recombinant hepatitis B vaccine for the prevention of hepatitis B virus infection is in practice in different parts of the world since its availability in 1986. Government of Bangladesh has also included hepatitis B vaccine in EPI schedule since 2005. Materials and methods: This study was carried out to assess the seroconversion status among hepatitis B vaccinated individuals. A total of 190 individuals including 150 vaccinated persons and 40 non-vaccinated apparently healthy individuals were included as study population. Sources of vaccinated persons were from both EPI and non- EPI schedule of vaccination. Age and sex matched non-vaccinated individuals served as controls for the study. All individuals constituting the study population were screened for HBsAg by Immunochromatographic strip test and only HBsAg-negative persons were included for estimation of their anti-HBs titer. Results: Out of 150 vaccinated individuals, 133(88.67%) were found to have anti-HBs titer in the protective level (>10 IU/L), while 17(11.33%) individuals had anti-HBs titer below the protective level ( 0.05). Vaccinated individuals from lower socioeconomic condition have had comparatively low rate of protective antibody than people from middle and upper classes. Conclusion: Recombinant HB vaccine induces good level of protective immunity among vaccinated persons. Keywords: Hepatitis B; hepatitis B vaccine; seroconversion; Bangladesh DOI: 10.3329/jom.v11i2.5461 J MEDICINE 2010; 11 : 143-150

9 citations


Journal ArticleDOI
TL;DR: The incidence of congenital hypothyroidism in southern part of the country is quite high in relation to global incidence, although this is not the national picture but the high figure is alarming.
Abstract: Background: Congenital hypothyroidism is the commonest preventable cause of mental retardation. It is more prevalent in endemic goiter regions like Bangladesh. But magnitude of the problem has not been studied at national level. Objective: To detect the incidence of congenital hypothyroidism among the newborn delivered in Khulna Medical College Hospital in southern part of Bangladesh and to rationalize the development of neonatal screening program. Methodology: All the living newborns delivered between Oct '01 to June ‘05 in Khulna Medical College Hospital were included in the study. After taking the relevant information from mother, cord blood sample were collected from the newborn within 24 hours of birth and kept in freezer. At the end of collection of each two month, the lot of blood sample was sent to the laboratory of Institute of Nuclear Medicine, Dhaka for radioimmunoassay of TSH. Potential cases with TSH value above 10 MIU/L were recalled for thyroid function test for confirmation of diagnosis. Results: After discarding unsatisfactory samples, 1353 samples were assayed for TSH. Among the study population 88.2% hailed from Khulna district and the rest of the cases came from neighboring districts. Male to female ratio was 1.2:1. Regarding the birth weight 33.4% babies were of low birth weight. TSH above 10 MIU/L were found in 35 babies among whom one baby was hypothyroid and the other member of the twin was also hypothyroid although the TSH level was below 10 MIU/L. Thus incidence of congenital hypothyroidism was 1.5 per thousand living newborn among the studied cases. Conclusion: The incidence of congenital hypothyroidism in southern part of the country is quite high in relation to global incidence. Although this is not the national picture but the high figure is alarming. So, neonatal screening program should be implemented as soon as possible to find out the real case burden in the community and thereby to take care of them and reduce the number of mentally retarded children in our country. Key words: Congenital hypothyroidism; neonatal screening; mental retardation. DOI: 10.3329/bjch.v29i3.6186 Bangladesh J Child Health 2005; Vol 29 (3): 88-92

4 citations


Journal ArticleDOI
TL;DR: Ispaghula husk shows the better efficacy to improve the symptoms of IBS like abdominal pain or discomfort and sense of well being than Oxyphenonium bromide.
Abstract: Background: Irritable bowel syndrome is a chronic continuous or remittent gastrointestinal illness characterized by frequent unexplained symptoms that include abdominal pain, bloating, and bowel disturbance, in our country, no study has been conducted using the Ispaghula husk and oxyphenonium bromide for the treatment of IBS patients. Objectives: To compare the efficacy of treatment with Ispaghula husk and Oxyphenonium bromide. Methods: Total sixty patients diagnosed clinically as irritable bowel syndrome irrespective of subtype who fulfilled the Rome II criteria were included equally into two groups-Group-I (Ispaghula group) & Group-II (Oxyphenonium group). In Group-I patients were given 30gm of Ispaghula husk at night daily and in Group-II patients were given 5mg of oxyphenonium bromide. After six weeks the clinical parameters of both the groups recorded in the case record forms were taken for analysis. Results: The mean age of the patients in the Group- I were 33.4±11.9 yrs and that of the patients in the Group-II were 31.0±17.5 yrs. Male and female ratio in group I was 14:1 and in group II was 23:7. Most of the patients were recorded in the age group of 26-30 in both groups. Symptom free patients were graded in 16.7% patients in Group-I and in 20% patients in Group- II. No improvement was occurred in 16.7% patients in Group-I and in 10% patients in Group-II. Conclusions: Ispaghula husk shows the better efficacy to improve the symptoms of IBS like abdominal pain or discomfort and sense of well being than Oxyphenonium bromide. Oxephenonium bromide shows the better efficacy to decrease the stool frequency from base line than Ispaghula husk. DOI: 10.3329/bsmmuj.v3i1.5506 BSMMU J 2010; 3(1): 3-8

1 citations


Journal ArticleDOI
TL;DR: A 27 years old women para -1 had a complaint of dullache pain in right iliac fossa for 5 days with irregular spotting and her pregnancy test was positive but signs and symptoms of pregnancy were absent.
Abstract: A 27 years old women para -1 had a complaint of dullache pain in right iliac fossa for 5 days with irregular spotting. Her previous menstrual cycle was normal but in last one month she had an irregular spotting. On examination she was normotensive. Hb% was 65%. there was no tenderness during per abdominal examination but tenderness during per vaginal examination on right side. Transvaginal ultrasonography (TUVS) detected a degenerative sub serous fibroid of 3.5 x 3 cm on the right fundoanterior side, both adnexae were normal, no fluid was present in cul-de-sac. Her pregnancy test was positive but signs and symptoms of pregnancy were absent. Operative plan was intervention by laparoscope. An unruptured interstitial ectopic pregnancy was found at the anterolateral wall of the fundus. Laparoscopic excision was done and the uterine wall sutured with 2/0 polyprolylin. Post operative outcome was good. DOI: 10.3329/jbcps.v26i3.4199 J Bangladesh Coll Phys Surg 2008; 26: 147-148

Journal ArticleDOI
TL;DR: A rare radiological finding of phytobezoar obstruction is reported in a patient, who underwent gastrojejunostomy operation, and the patient was treated surgically and had an uneventful recovery.
Abstract: Small bowel phytobezoars are, though well-known, a rare cause of mechanical intestinal obstruction. It occurs mainly in the patients who had a previous gastric operation.We present a case of phytobezoar obstruction in a patient, who underwent gastrojejunostomy operation. We also report here a rare radiological finding of phytobezoar obstruction. The patient was treated surgically and had an uneventful recovery. DOI: 10.3329/jbcps.v27i2.4253 J Bangladesh Coll Phys Surg 2009; 27: 99-102