Khulna Medical College

About: Khulna Medical College is a healthcare organization based out in Khulna, Bangladesh. It is known for research contribution in the topics: Pregnancy & Hysterectomy. The organization has 266 authors who have published 203 publications receiving 964 citations. The organization is also known as: Khulna Medical College, Khulna & KMC.

Outcome of Partial Splenectomy for Hypersplenism in Children with Thalassemia

Abstract: Background: Total splenectomy, exposes children to the high risk of overwhelming postsplenectomy infections (OPSI). To avoid these adverse consequences, partial splenectomy has long been practiced for thalasseemia in children. It has been reported that the partial splenectomy keeps the child immunologically competent, hematologically stable with minimum blood transfusion and makes their life more comfortable in comparison to total splenectomy. Objectives: To compare the results of partial and total splenectomy. Methodology: This prospective interventional comperative study was done in the department of Pediatric Surgery, BSMMU from 2010 to 2012. Children who underwent partial splenectomy were considered as the case and who underwent total splenectomy as the control. Number of blood (RCC) transfusions (ml/ kg/year), Peripheral blood film (Hb%, WBC count, platelet count, Howell-Jolly body, serum bilirubin), volume of liver (ml), volume of spleen (ml), number of OPSI case, were compared between the case and control groups both pre and postoperatively. Results: Postsplenectomy blood transfusion requirement is comparatively more decreased in control group than case group. The inter group difference at 6 month is significant (p= 0.004). Peripheral blood pictures are improved in both groups. Post splenectomy hemoglobin level was increased in both groups but it was maintained at a more static fashion in control group than case group (P = 0.114). Howell-jolly body in the partial splenectomy group disappeared almost completely at month 6, while the same inclusion body in the total splenectomy group appeared in all the children (p= 0.001). There was no postsplenectomy infection in case group while two found in control group. After partial splenectomy the residual volume of the spleen was gradually increasing. The increase in volume of the liver was notably greater in the total splenectomy group than that in the partial splenectomy group (p< 0.05). Conclusion: Partial splenectomy in patients with ²-thalassemia is effective in controlling hemolysis, improving peripheral blood picture while preserving the residual splenic phagocytic and immune function. J. Paediatr. Surg. Bangladesh 6 (2): 39-46, 2015 (July)

Etiological basis of pleural effusion in a teaching hospital

Abstract: Background: A pleural effusion represents the disruption of the normal mechanisms of formation and drainage of fluid from the pleural space. Pleural effusions are associated with diseases of varied etiologies and often carry a grave prognosis. Objective: To evaluate the common cause of pleural effusion in developing country and also to compare to that of developed countries. Methods: This is a prospective observational study. Fifty four patients, diagnosed with pleural effusion on admission were randomly selected from I April 2016 to 30 September 2016 in Medicine ward of Khulna medical college hospital. Etiologic diagnosis was established by sequential clinical history and findings on physical examination, laboratory tests, chest radiograph, CT Scan of chest and pleural fluid analysis. Patients who remained undiagnosed were subjected to fibre-optic bronchoscopy, thoracoscopic pleural biopsy, and histopathology. Results : Etiologic diagnosis of pleural effusion was established in 50 (92.59%); tuberculosis 25 (46.29%), parapneumonia 10 (18.52%) malignancy 7 (12.96%) nephrotic syndrome 3 (5.55%),cirrhosis of liver disease 2 (3.71%) congestive cardiac failure 2 (3.71%), systemic lupus erythematosus I (1.85%). 4 patients (7.41%) remain undiagnosed. Among subjects, exudative pleural effusion was 43 (79.63%) and transudative 11 (21 57%). Among exudative pleural effusion sputum for AFB positive 15 (34.88%), FNAC 10 (23%), fibreoptic bronchoscopy was positive 2 (4.6%), gene expart test for tuberculosis positive in 5 (11.62%). Conclusions: Most of the pleural effusion cases are diagnosed as tuberculosis, Early and adequate treatment results in complete recovery of the patient. Bang Med J (Khulna) 2016; 49 : 27-30

A descriptive study of sleep disorders and their impact in 2 selected schools in a divisional city of Bangladesh

Abstract: Background: Sleep disorders are common in children and adolescents and have an important negative impact on their quality of life. Objective: This study was done to estimate the prevalence of sleep problems in 2 selected schools in a divisional city of Bangladesh and to evaluate the impact of sleep disorders on school performance. Method: One thousand school children between 5 to 16 years of age from the two largest schools (one boys’ and one girls’ school) were randomly selected for this study from July to December 2011. A two step procedure involved self-administered questionnaire and direct interview of the affected children and parents. The questionnaire was based on diagnostic criteria for category based classification by American Academy of Sleep Medicine. Academic performance was evaluated on the basis of cumulative results of term examinations throughout the year. Results: A total of 713 (71.3%) questionnaires were eventually returned. Of the children, 353 were boys and 360 were girls. Three hundred and ninety two sleep problems were noted in 202 (28.3%) school children and mean (SD) age of sufferer was 139 (32) months. Among the primary sleep problems, parasomnia (47.8%) was highest followed by dyssomnia (9.5%). Prominent disorders under parasomnia were nightmares (7.4%), nocturnal enuresis (4.1%) and sleep terror (3.4%) and that under dyssomnia was obstructive sleep apnoea (3.6%). School performance was significantly poor in the children with sleep disorders (p Conclusions: In the 2 selected schools in Khulna city of Bangladesh 28.3% had sleep problems. Sleep disorders had a significant negative impact on school performance. (Key words: Sleep disorder; schoolchildren; prevalence; school performance) Sri Lanka Journal of Child Health , 2014; 43 (4): 212-218 DOI: http://dx.doi.org/10.4038/sljch.v43i4.7765

Effect of Fenugreek (Methi) on Cortical Thickness of the Thymus in Streptozotocin-Induced Diabetic Rats

Abstract: Objective: To find out microscopically whether Trigonella foenumgraecum (fenugreek seeds/methi seeds) has got any preventive role against the lowering of cortical thickness of the thymic lobules in diabetes mellitus. Design: An experimental study on Long Evans rats which were divided into three equal groups depending on their different shorts of dietary feeding and drug treatment. Setting: Anatomy department of IPGMR (Institute of Post Graduate Medicine and Research) at present BSMMU (Bangabandhu Sheikh Mujib Medical University) and BIRDEM (Bangladesh Institute of Research and Rehabilitation in diabetes, Endocrine & Metabolic Disorders). Subjects: Fifty eight healthy young Long Evans rats of either sex weighing 72 to 174gm aged between 50 to 60 days were used in this study. Main outcome measures: Variation of cortical thickness of the thymic lobules in different groups of rat. Result: Cortical thickness in the nondiabetic control group, which ranges from 30.17 to 36.99. and the mean was 34.83 ± 0.60. In diabetic control group the cortical thickness ranges from 17.78 to 26.46 and the mean was 21.85 ± 1 On the other hand, in the fenugreek- treated diabetic rats the cortical thickness ranges from 25.71 to 32.95 and mean cortical thickness was 30.49 ± 0.75. Conclusion: Fenugreek showed a tendency of acting against lowering of the cortical thickness of the thymic lobule of Streptozotocin-induced diabetes mellitus. However, further investigations are recommended for establishing fenugreek as a safe, useful effective agent to preserve the cortical thickness improving the diabetic condition by acting as antidiabetogenic agent. Key words: Diabetes mellitus, Differential lymphocyte count, Fenugreek, Thymus doi: 10.3329/bja.v7i1.3017 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 37-41

Helicobacter Pylori Infection And Gastric Cancer: Is It Our National Problem?

Abstract: Gastric cancer is a leading cause of cancer death worldwide. In Bangladesh it ranks a leading position among the cancers patients. A large body of evidence supports a causal role of Helicobacter pylori in the majority of gastric malignancies. Scientists throughout the world explored and reached to the understanding about the pathogenesis of their relationship, but much remains to be learned. Moreover, because of the high prevalence of infection, the lack of definitive trials, and the challenges of H. pylori treatment, there remains a debate regarding the consensus on the role of routine screening and treatment of this infection to prevent cancer. This article reviews the current knowledge on H. pylori and its role for gastric cancer, present status of Bangladesh and a recommendation for reduction of the infectivity among the common population. J Bangladesh Coll Phys Surg 2018; 36(2): 70-76