Khulna Medical College

About: Khulna Medical College is a healthcare organization based out in Khulna, Bangladesh. It is known for research contribution in the topics: Pregnancy & Hysterectomy. The organization has 266 authors who have published 203 publications receiving 964 citations. The organization is also known as: Khulna Medical College, Khulna & KMC.

A comparison of drug treatment outcome of irritable bowel syndrome patients with and without education: a randomized controlled study

Abstract: The objective of the prospective randomized controlled comparative study to explore about the role of education in the treatment of irritable bowel syndrome (IBS), a chronic continuous or remittent gastrointestinal illness characterized by frequent unexplained symptoms that include abdominal pain, bloating and bowel disturbance. The patients who fulfilled the set criteria of this study and had normal physical examination were considered to undergo screening investigations (Hb%, TC, DC, ESR, blood glucose, serum TSH, stool for R/M/E and short colonoscopy or double contrast barium enema) to exclude any organic disease. In order to administer the same pharmacological treatment only diarrhea predominant patients without any organic disease were recruited for the present study. The number of recruited patients was 80. Of them, 40 patients were given only pharmacological management with Mebeverine Hydrochloride 135 mg thrice daily half an hour before meal and Amitryptyline 10 mg at night for 6 months, and the other 40 patients were given education by a structured and planned educational class for 1 hr in addition to the same pharmacological treatment. In both groups, changes of symptoms and quality of life of the patients were assessed by using a valid IBS related quality of life (IBS-QOL) instrument. The results showed that significant improvement occurred in both the groups of patients at 1 month and 6 months in respect to their baseline IBS-QOL score. But the improvement was not significantly higher in the group with education in comparison to the group without education. Therefore, it can be concluded that the educational class had no extra impact on drug treatment protocol for IBS used in the present study. Mediscope Vol. 2, No. 2: July 2015, Pages 22-27

Studies on Antibacterial Activity and Brine Shrimp Toxicity of Leaf Extract of Cassia grandis

Abstract: Antibacterial activity and toxicity of ethanol extract of Cassia grandis leaves to Brine Shrimp was evaluated. Five Gram-positive and 4 Gram-negative bacteria, namely Sarcina lutea , Bacillus megaterium , Bacillus subtilis , Streptococcus s-haemolyticus , Staphylococcus aureus , Pseudomonas aeruginosa , Escherichia coli , Salmonella typhi and Klebsiella pneumoniae were tested using disc diffusion method. The extract was inactive at the concentration of 30 μg/disc but exhibited moderate to good activity at concentration of 200 μg/disc against the tested bacteria. In Brine Bhrimp lethality bioassay test, it was observed that LC 50 value of the extract was 10.68 μg/ml. From these findings, it is indicative that C. grandis may be useful against microbial diseases. Key words: Antibacterial activity, Brine shrimp, Cassia grandis doi: 10.3329/bjmm.v3i1.2966 Bangladesh J Med Microbiol 2009; 03 (01): 17-19

Prevalence of gallstones and biliary sludge formation during pregnancy detected by ultrasonography

Abstract: The risk of gallstones is thought to increase with number of pregnancies. Cholesterol gallstones are more prevalent in women than men and primarily related to sex steroids, particularly progesterone. During pregnancy there are changes in bile composition and gallbladder motility that promote gallstone formation. This study was conducted to determine incidence and outcome of pregnancy related biliary sludge and gallstone formation. Two hundred and nine consecutive expectant women were evaluated by ultrasonography at 1st trimester, 3rd trimester and at 4-6 weeks after delivery. Socio-demographic, medical and obstetrical history were taken and recorded. Incidence of gallstone and sludge formation were found 5.7% and 2.9%, respectively. The results suggest that pregnancy may be a risk factor for gallstone and biliary sludge formation. Mediscope Vol. 4, No. 2: Jul 2017, Page 21-24

Effect of Ispaghula and Oxyphenonium Bromide on the Symptoms of Irritable Bowel Syndrome - A Comparative Study

Abstract: Background: Irritable bowel syndrome is a chronic continuous or remittent gastrointestinal illness characterized by frequent unexplained symptoms that include abdominal pain, bloating, and bowel disturbance, in our country, no study has been conducted using the Ispaghula husk and oxyphenonium bromide for the treatment of IBS patients. Objectives: To compare the efficacy of treatment with Ispaghula husk and Oxyphenonium bromide. Methods: Total sixty patients diagnosed clinically as irritable bowel syndrome irrespective of subtype who fulfilled the Rome II criteria were included equally into two groups-Group-I (Ispaghula group) & Group-II (Oxyphenonium group). In Group-I patients were given 30gm of Ispaghula husk at night daily and in Group-II patients were given 5mg of oxyphenonium bromide. After six weeks the clinical parameters of both the groups recorded in the case record forms were taken for analysis. Results: The mean age of the patients in the Group- I were 33.4±11.9 yrs and that of the patients in the Group-II were 31.0±17.5 yrs. Male and female ratio in group I was 14:1 and in group II was 23:7. Most of the patients were recorded in the age group of 26-30 in both groups. Symptom free patients were graded in 16.7% patients in Group-I and in 20% patients in Group- II. No improvement was occurred in 16.7% patients in Group-I and in 10% patients in Group-II. Conclusions: Ispaghula husk shows the better efficacy to improve the symptoms of IBS like abdominal pain or discomfort and sense of well being than Oxyphenonium bromide. Oxephenonium bromide shows the better efficacy to decrease the stool frequency from base line than Ispaghula husk. DOI: 10.3329/bsmmuj.v3i1.5506 BSMMU J 2010; 3(1): 3-8

Alteration of P53, hMLH1, and HER2 Gene in Bangladeshi Gastric Cancer Patients: Their Association with H. pylori Infection and Clinicopathological Factors

Abstract: Background Gene alterations are required for the development of gastric cancer, which are influenced by environmental and host factors. We conducted the present study to find the status of Helicobacter pylori (H. pylori) infection and its association with altered genes P53, hMLH1, and HER2 in gastric cancer patients and to analyze their correlation with clinical, pathological, and environmental factors.Method This was a cross-sectional study. For genetic (P53 and hMLH1) study of the gastrectomized tissue DNA extraction and optimization, we performed PCR amplification and DNA sequencing. HER2 was studied by immunochemical technique. The results were matched with tumor status, age and sex, smoking, and H. pylori antibody status of the patients to find their association.Results The mean age of the patients was 52.91 (±13.94) years. Among the 45 patients selected for genetic tests, 12 aged 40 or more and 33 aged over 40. Among the genes, 33(73.3%) in P53 and 17(37.7%) in hMLH1 were mutated and 11(24.2%) in HER2 were found to be overexpressed. Chi square and regression analysis showed that they all had associations with H. pylori positivity (P 1). hMLH1 was associated with the location of the tumor, smoking, sex, blood group, and age, and P53 was found to be affected by extra salt intake, sex, blood group, and age of the patients (P ≤ 0.05 ).Conclusion Genetic mutation was found in nearly all the patients with gastric cancer, which was significantly associated with H. pylori infection. Mass eradication of this organism might play a role in reducing cancer incidence in Bangladesh.