Khulna Medical College

About: Khulna Medical College is a healthcare organization based out in Khulna, Bangladesh. It is known for research contribution in the topics: Pregnancy & Hysterectomy. The organization has 266 authors who have published 203 publications receiving 964 citations. The organization is also known as: Khulna Medical College, Khulna & KMC.

Tuberous sclerosis misdiagnosed as epilepsy

Abstract: Tuberous sclerosis (TS) is a rare genodermatoses characterized by neurological symptoms and hamartomas in multiple organs including brain, skin, kidney, eyes, heart, lungs & G.I tract. The classic triad of epilepsy, adenoma sebaceum and mental retardation usually occurs in one third of the patients, thus requiring high index of suspicion to diagnose TS. Otherwise it may easily be misdiagnosed as epilepsy or neurofibromatosis. Here we present a case of tuberous sclerosis in 11 year old girl misdiagnosed as epilepsy because of her convulsions. A comprehensive medical history including family history, thorough physical examinations, clinical suspicion and neuroimaging are required to confirm the diagnosis. DOI: http://dx.doi.org/10.3329/bmjk.v46i1-2.18238 Bang Med J (Khulna) 2013; 46 : 31-33

Outcome of treatment of OPC poisoning patients with atropine or atropine plus pralidoxime

Abstract: Background: Organophosphorus compound (OPC) poisoning is common in Bangladesh and management facility is not adequate in most hospitals. Both inj. Atropine and inj. Pralidoxime is used as antidote for the management of OPC poisoning, although there is controversy regarding benefit of inj. Pralidoxime. Objective: This randomised clinical trial was conducted to compare the outcome of OPC poisoning patients treated by inj. Atropine along with supportive measures and by inj. Atropine plus inj. Pralidoxime along with supportive measures . This study also evaluated the clinical profile of OPC poisoning patients. Methods: A total number of 109 patients, admitted in medicine ward in Khulna medical college hospital during one year period were included in this randomised clinical trial. The patients were divided into two groups according to alternate day of admission in the medicine wards. Forty nine patients of group A was treated by inj. atropine only along with other supportive measures required and group B of 60 patients was treated by inj. atropine plus inj. pralidoxime along with supportive measures. Results: 49 patients of group A was treated with atropine alone and 60 patients in group B was treated with atropine plus pralidoxime. Death rate was 14.28% in atropine treated group and 16.66% in atropine plus pralidoxime treated group (p=0.733). The difference in death rate is not statistically significant. Four (8.18%) patients from atropine treated group and 4 (6.67%) patients from pralidoxime intervention group developed respiratory failure and ventilatory support was given in ICU. These 8 patients recovered. But this difference in development of respiratory failure is not statistically significant (p=0.766). The difference of death rate between male and female (12.5% Vs 18.87%) is not also significant (p=0.360). Conclusion: This study reveals that pralidoxime provides no better outcome in the management of OPC poisoning patients. Bang Med J (Khulna) 2017; 50 : 3-7

Rudimentary Horn Pregnancy Misleading Abdominal Missed Abortion

Abstract: Pregnancy in a rudimentary horn is a very rare condition. It is responsible for severe complications and also a life threatening condition as it mostly terminates by rupture of pregnancy. This was a case of non communicating unruptered pregnancy which was misdiagnosed on 1st and 2nd transabdominal ultrasonography, progressing to 22weeks gestation and ends in a missed abortion. A transvaginal ultrasonography revealed it as an abdominal pregnancy and on laparotomy confirmed diagnosis was non communicating rudimentary horn pregnancy. Pregnancy sac with foetus was removed intact and patient. recovered without any complications. Gravid rudimentary horn may be misdiagnosed as abdominal pregnancy and are of interest in management. DOI: http://dx.doi.org/10.3329/jom.v15i1.19879 J Medicine 2014; 15: 74-76

Biological Agents in the Treatment of Rheumatoid Arthritis

Abstract: Rheumatoid arthritis (RA) is the commonest joint disease with considerable morbidity and mortality. Conventional disease modifying antirheumatic drugs like methotrexate form the cornerstone of therapy. These drugs have several limitations in terms of slow onset of action, adverse effects and modest remission rates. Several cytokines are involved in the pathogenesis of RA. Biological agents that specifically inhibit the effects of tumour necrosis factor-alpha (TNF-a) or interleukin-1 (IL-1) represent a major advancement in the treatment of RA. By targeting mediators that are directly involved in the pathogenesis of RA, these agents slow the radiological progression of bone and cartilage damage in joints, prevent or delay the onset of disability. These are highly specific and better tolerated. The use of these biological agents needs careful monitoring for side effects, including the development of infection. Additional anti-cytokine agents for the treatment of RA are under further development. Key words: Rheumatoid arthritis; biological agents; inflammatory cytokine. DOI: 10.3329/jbsp.v29i1.7168 J Bangladesh Coll Phys Surg 2011; 29:27-31

Leprosy - An Overview

Abstract: Medicine Today 2011 Volume 23 Number 01 Page 44-50 DOI: http://dx.doi.org/10.3329/medtoday.v23i1.11946