Khulna Medical College

About: Khulna Medical College is a healthcare organization based out in Khulna, Bangladesh. It is known for research contribution in the topics: Pregnancy & Hysterectomy. The organization has 266 authors who have published 203 publications receiving 964 citations. The organization is also known as: Khulna Medical College, Khulna & KMC.

Clinical profile of acute flaccid paralysis.

Abstract: This study was done to determine the clinical course, cause and outcome of Acute Flaccid Paralysis (AFP) in children. All AFP cases (< 15 years) in the children's ward of Khulna Medical College Hospital (Bangladesh) were recorded, investigated and followed up to sixty days as a part of passive surveillance. Main outcome variables were vulnerable age group, vaccine status, predominant limb involvement, clinical variants, virus isolation and residual paralysis. Thirty-four children with AFP were admitted in hospital in the last three years with the highest number (14) in 1998. The majority of children belonged to the age group 5-9 years with a male female ratio of 1.3:1. Nearly one third of the cases were either partially vaccinated or not vaccinated at all. The lower limbs bore the brunt of paralysis excepting a few (14.7%). Clinically, Guillain Barre Syndrome was the commonest (47.1%) followed by encephalomyelitis. No poliovirus was isolated from these cases. Residual paralysis was observed in four out of ten cases who returned for follow up. AFP will continue to occur even after eradication of poliomyelitis and Guillain Barre Syndrome is the most important clinical entity for this.

Distribution of Liver Disease in Bangladesh: A Cross-country Study.

Abstract: Introduction 'Hepatology', as an independent discipline of medical science, has recently been established in Bangladesh. The aim of this study was to formulate the distribution of pattern of liver diseases in this country. Materials and methods In this retrospective study, data regarding patients of liver diseases from the seven different administrative divisions of Bangladesh between January 2012 and 2013 were compiled. Results The study included 59,227 patients (age ranged 15-95 years). Majority of the patients were males (67.9%). Although all patients appeared at the department of hepatology, 13.2% were diagnosed with liver diseases, but a vast majority of patients (77.35%) were suffering from nonulcer dyspepsia or irritable bowel syndrome. Patients with liver diseases were mostly suffering from chronic liver diseases (CLDs) (37 -69%). Complication of CLD, like hepatic encephalopathy, was less frequent in regions with better healthcare system. Nonviral infections, like liver abscess and biliary ascarisis, were not uncommon. Acute hepatitis was another very common entity and contributed to approximately 20% cases. Conclusion This study provides insight about heterogeneous distribution pattern of liver diseases in different regions of Bangladesh.How to cite this article: Rahman S, Ahmed MF, Alam MJ, Debnath CR, Hoque MI, Hussain MM, Shamsul Kabir AKM, Karim MF, Khondokar FA, Mahtab MA, Masud MG, Mollick MKU, Moben AL, Noor-E-Alam SM, Podder PK, Raha AK, Rahim MA, Rashid MHO, Zaki KMJ, Akbar SMF. Distribution of Liver Disease in Bangladesh: A Cross-country Study. Euroasian J Hepato-Gastroenterol 2014;4(1):25-30.

Effect of fenugreek seeds on the fasting blood glucose level in the streptozotocin induced diabetic rats.

Abstract: In this experiment defatted Trigonella foenumgraecum (fenugreek seeds/methi seeds) has used as the antidiabetogenic herbal medicine. The experiment was carried out in Bangabandhu Sheikh Mujib Medical University and BIRDEM from 1996 to 1998 on a total of 58 Long Evans rats of either sex. They were 50-60 days young rats with average body weight 72-174 gm. Among the total, 10 rats were treated with only vehicle called as non-diabetic control rats, 48 rats were treated with Streptozotocin (STZ) at a dose of 90 mg in 1 ml of citrate buffer solution per kg body weight, among which 20 were diabetics. Ten (1 died, 1 escaped) diabetic rats were again treated with fenugreek called as Fenugreek-treated diabetic rats and the rest 10 diabetic rats were called as diabetic control rats. The change in the mean fasting blood glucose (FBG) level in different groups of rat from day 5 from streptozotocin injection were higher in diabetic control group and in fenugreek-treated diabetic group than in non diabetic control group. The FBG level on day 13 the mean in non-diabetic control group was 5.21 mmol/L. In diabetic control group and in fenugreek-treated diabetic group the mean FBG level were 24.33 mmol/L and 9.89 mmol/L respectively. So, from this experiment it may be concluded that fenugreek decreases the FBG level considerably by improving diabetes mellitus.

Fahr's syndrome

Abstract: Miss Merry, 17 years old girl hailing from Barobila., Patkelghata, Satkhira was admitted in Khulna Medical College Hospital on 27-06-2010 with the complaints of fever, convulsion and unconsciousness for 7 days. She has also some hearing impairment, behavioral abnormalities and stunted growth since her childhood. On examination she was deeply unconscious, anaemic and febrile. CT scan of brain reveals multiple bilateral symmetrical calcification seen in the brain parenchyma involving basal ganglia, thalamus, para ventricular region, and cerebellar nucleus. Multiple ill defined hypodense areas are seen in the both parieto-occipital region, suggestive of Fahr's syndrome with meningoencephalitis. DOI: http://dx.doi.org/10.3329/bmjk.v45i1-2.13628 Bang Med J (Khulna) 2012; 45 : 33-35

Levofloxacin-Induced Fatal Toxic Epidermal Necrolysis

Abstract: TO THE EDITOR: Chronic critical limb ischemia results from chronic underperfusion of a limb. This is typically manifested by ischemic pain at rest, nonhealing ulcerations, or gangrene of the affected limb.1 As many as 20% of patients with chronic critical limb ischemia die over 6 months, mainly of vascular disease, and only 45% will survive without having an amputation.2 We present the case of a man whose lower extremity vascular disease deteriorated into chronic critical limb ischemia with ischemic pain at rest. Our case suggests the potential utility of gabapentin in the symptomatic management of pain and functional decline in chronic critical limb ischemia. Case Report. A 56-year-old man with an anxiety disorder complicated by abuse of nicotine, alcohol, and cocaine; coronary artery disease; and peripheral vascular disease developed severe left lower leg pain. He stopped using alcohol and cocaine and cut back on his smoking, but despite these lifestyle changes, the pain progressed. At first, the patient experienced leg pain only while walking, but after stopping exercise, he then developed leg pain at rest. Doppler ultrasound studies revealed marked bilateral femoropopliteal occlusive disease, more pronounced in the left. Leg pain at rest disrupted the patient’s sleep, and he became clinically depressed. He was admitted to a psychiatric inpatient service and continued on his home medications: venlafaxine 300 mg/day for depression, aspirin 325 mg/day, atenolol 50 mg/day, quetiapine 50 mg in the morning and 400 mg at night, trazodone 100 mg at night, and acetaminophen 1000 mg with hydrocodone 10 mg/day. After a week without change in his pain or mood, the patient was started on gabapentin 600 mg 3 times a day. This was increased over one week to 1200 mg 3 times a day. At this dose, the pain was significantly reduced. The patient no longer had rest pain, was sleeping well at night, and was spontaneously ambulating and participating in physical therapy. As his pain lessened, the patient’s mood improved. By the time of discharge from the hospital, he no longer had subjective evidence of chronic critical limb ischemia. Doppler ultrasound was not repeated prior to or immediately after discharge. Discussion. Chronic pain itself may accelerate decline in chronic critical limb ischemia and can precipitate or worsen major depressive disorder.3 Major depressive disorder can cause abnormal arterial vasoconstriction and increased platelet aggregation, exacerbate ischemia, and reduce a patient’s self-care.4,5 Reduced aerobic activity has a critical impact on the course of vascular disease. In our case, the symptomatic pain relief the patient obtained from a trial of gabapentin was striking and allowed a marked functional improvement. As of April 17, 2005, gabapentin had not been reported as a treatment for rest pain in chronic limb ischemia. The safety of gabapentin alone and in combination with other agents, and the patient’s marked improvement in response to gabapentin, suggest further investigation is warranted of the potential utility of gabapentin for patients with rest pain due to chronic critical limb ischemia.