Khulna Medical College

About: Khulna Medical College is a healthcare organization based out in Khulna, Bangladesh. It is known for research contribution in the topics: Hysterectomy & Cancer. The organization has 266 authors who have published 203 publications receiving 964 citations. The organization is also known as: Khulna Medical College, Khulna & KMC.

Experience of peptic ulcer perforation over a decade in a teaching hospital of southern Bangladesh.

Abstract: Objective To determine disease characteristics, check the treatment status and compare outcome with other series. Design and setting A retrospective study in a single unit of the Department of Surgery of Khulna Medical College Hospital, south west Bangladesh. Patients and methods After diagnosis by clinical and radiological examination, 491 patients were treated during the period July 1992 to November 2002. Two options of treatment were carried out: simple closure and peritoneal lavage in 364 cases, and 127 patients managed by non-surgical methods. Main outcome measures mortality and morbidities. Results Male:female ratio was 445:46, average age 43 years. Mortality in the surgical group was 6.8% and in the non-surgical group 0.02%. Conclusion Perforated peptic ulcer is prevalent even after the wide use of H2 receptor antagonists. Strict case selection for surgical and non-surgical treatment has reduced mortality. These results support the case for non-operative treatment and for conservative surgery.

Skin eruptions following treatment with Iodine-131 for hyperthyroidism: a rare and un-reported early/intermediate side effect.

Abstract: BACKGROUND : Iodine-131 ( 131 I) is a well-established method for the treatment of hyperthyroidism. Following such therapy, patients may experience symptoms relating to early or delayed side effects that can be prevented or minimized if necessary measures are taken. We have noticed an unusual side effect of 131 I therapy in the form of a skin eruption (iododerma) and aimed at assessing the frequency and severity of this side effect. MATERIAL AND METHODS : Retrospective review of 141 patients treated with 131 I between January 1994 to December 2000 (86 F, 55 M; mean age 41.35 ± 11.02 years) was performed. The dose of 131 I ranged from 250-500 MBq. Post therapy clinical and biochemical evaluation of thyroid function was done at 6 weeks, 3, 6, and 9 months then annually. RESULTS : Of the 141 treated patients, 3 patients (2.1%) presented with iododerma 4-6 weeks after 131 I therapy administration. Lesions were observed at both ankles & lower legs in all 3 cases. All lesions disappeared within 6 months with no residual effect. No other skin lesions were seen thereafter during the follow-up period. CONCLUSION : Iododerma is a rare complication of 131 I therapy that has not been reported before. It appears within 4-6 weeks after therapy and is a self-limiting condition.

Utility of misoprostol for labor induction in severe pre-eclampsia and eclampsia.

Abstract: Objectives: To determine the effectiveness and safety of misoprostol in severe pre-eclampsia and eclampsia patients with unripe cervix. Methods: A prospective observational study was carried out in 135 severe pre-eclampsia and eclampsia patients who required termination of pregnancy at the Department of Obstetrics and Gynecology, Khulna Medical College Hospital, Khulna, Bangladesh during January 2002 to October 2003. Fifty micrograms of misoprostol was used every 4 h in cases of unripe cervix (Bishop score ≤ 6) in severe pre-eclampsia and eclampsia patients. Maternal and perinatal outcome as well as any complications were recorded. Results: In severe pre-eclampsia and eclampsia patients vaginal delivery occurred in 79.3 and 80.5% of cases, and cesarean section was performed in 20.6 and 19.4% of cases, respectively. The maximum required responsive dose was 50–150 µg. Oxytocin augmentation was required in 29.3 and 35% of cases, respectively. Induction to delivery time was median 8 h, interquartile ranges 4.2–8.2 h in the severe pre-eclampsia group, and median 9 h, interquartile ranges 6.8–12.5 h in the eclampsia group, and average hospital stay was 3.4 ± 1.8 and 3.7 ± 1.7 days, respectively. The only maternal complications were hyperstimulation which occurred in 6.8 and 5.1% of cases, respectively. Neonatal death occurred in five (11.3%) and eight cases (12.1%), respectively. Conclusion: Intravaginal misoprostol is well tolerated and very effective for the induction of labor in severe pre-eclampsia and eclampsia patients with unripe cervix.

Snake bite in bangladesh

Abstract: Background: Snake bite is a real emergency and an important cause of morbidity and mortality. The objective of the study was to observe different aspects of snake bite including proportion of poisonous snake bites, clinical features of poisoning and outcome of treatment with polyvalent antivenom serum. Patients and Methods: 188 cases of snakebite were prospectively studied from June 2001 to Dec. 2002. Among them 132 were males and 56 were females. Age of the patients ranged from 10-70 yrs. Tourniquet was applied in all the cases of snake bite. Results: Peak incidence 74(39.36%) was in the age group 10-20 yrs. 108(57.44%) cases were venomous and 80(42.55%) were non-venomous. 158(89.04%) case of snake bite occurred out side the house and the common site of bite was lower extremities in 124 (65.95%) cases. Common feature of poisoning was drooping of the upper eyelid in 108 (100%) cases followed by external ophthalmoplegia in 82(75.92%) cases. Out of 108 venomous snake bite cases 101(93.52%) recovered completely and 7(6.66%) died after admission. 60(55.5%) cases recovered with only 20-30 ml (2-3 vials) of polyvalent antivenom serum. Conclusion: Snake bite cases were reported mostly in months of June and July. Young people were mostly affected with clinical presentation of drooping of eyelid and external ophthalmoplegia.

Comparative Efficacy of Dried Fruits of Carica Papaya Linn. and Vitamin-E on Preventing Hepatotoxicity in Rats

Abstract: In the absence of an effective treatment in modern medicine, efforts are being made to find suitable herbal remedies for hepatitis. This prospective experimental study was conducted in the department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka from July 2006 to June 2007 to evaluate the hepatoprotective effects of Carica papaya against carbon tetrachloride (CCl 4 ) induced hepatotoxicity and compared it with that of vitamin-E. Total 36 adult rats were used and they were divided into six equal groups namely A, B, C, D, E and F. All the rats were fed with normal diet and 2ml distilled water orally for 7 days. In addition, Group D received Carica papaya extract, Group E received olive oil and Group F received vitamin E orally per day for 7 days. On the seventh day CCl 4 ) was administered to all the rats except Group A and was sacrificed on 8th day of experiment. Serum bilirubin, alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase and hepatic histopathology were done thereafter. Carica papaya and vitamin E showed significant hepatoprotection against CCL 4 ) induced hepatotoxicity but Carica papaya showed more significant changes in ALP level than vitamin E. Prevention of hepatic necrosis and fatty degeneration were also observed in Carica papaya and vitamin E pretreated rats but there is no significant difference. DOI: http://dx.doi.org/10.3329/fmcj.v7i1.10295 Faridpur Med. Coll. J. 2012;7(1): 29-32