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Institution

King Faisal Specialist Hospital & Research Centre

HealthcareRiyadh, Saudi Arabia
About: King Faisal Specialist Hospital & Research Centre is a(n) healthcare organization based out in Riyadh, Saudi Arabia. It is known for research contribution in the topic(s): Detection limit & High-performance liquid chromatography. The organization has 58 authors who have published 157 publication(s) receiving 3527 citation(s).


Papers
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Journal ArticleDOI
Abstract: Lipase-catalyzed kinetic resolution of racemates is considered to be one of the most fascinating topics in asymmetric catalysis. This review focuses on some of the recent developments in this rapidly growing field demonstrating the versatility of the method in the resolution of racemates. The literature search is dated back to the last five years and covers some comprehensive examples. The main emphasis is on the use of lipases in organic solvents.

229 citations

Journal ArticleDOI
TL;DR: This review article focuses on some of the recent developments in the rapidly growing field of lipase-catalyzed kinetic resolution of racemates as a versatile method for the separation of enantiomers.
Abstract: Lipases have been well established as valuable catalysts in organic synthesis This review article focuses on some of the recent developments in the rapidly growing field of lipase-catalyzed kinetic resolution of racemates as a versatile method for the separation of enantiomers The literature search dates back to the last five years and covers some comprehensive examples The main emphasis is on the use of lipases in organic solvents

221 citations

Journal ArticleDOI
TL;DR: The speciation of arsenic [As( III) and As(V)] and chromium [Cr(III) and Cr(VI)] was carried out by high performance liquid chromatography by using mobile phases and UV-Vis and atomic absorption spectrometer (AAS) respectively.
Abstract: The speciation of arsenic [As(III) and As(V)] and chromium [Cr(III) and Cr(VI)] was carried out by high performance liquid chromatography. The column used was Econosil C18 (250×4.6 mm i.d., particle size 10 μ m). The mobile phases consisted of water–acetonitrile (80:20, v/v) for arsenic and 10 mM ammonium acetate buffer (6.0 pH)–acetonitrile (10:90, v/v) for chromium speciation separately and respectively. The detection was carried out by UV–Vis at 410 nm and atomic absorption spectrometer (AAS) respectively and separately. The values of α and Rs of As(III) and As(V) species were 1.4 and 1.5 respectively while the values of α and Rs for Cr(III) and Cr(VI) were 1.35 and 0.2 respectively. The effect of the acetonitrile percentages was also carried out on the speciation of arsenic only. The relative standard deviation and limit of detection were in the range of 0.01–0.02 and 0.4– 1.0 μ g/ml respectively.

118 citations

Journal ArticleDOI
TL;DR: The use of the column-switching technique is demonstrated to achieve the resolution of some drugs with multiple chiral centers using polysaccharide-type chiral stationary phases.
Abstract: Enantioseparation of drugs with multiple chiral centers is challenging. This article describes resolution of some drugs with multiple chiral centers using polysaccharide-type chiral stationary phases. Also, the use of the column-switching technique is demonstrated to achieve the resolution of this type of compounds.

107 citations

Journal ArticleDOI
04 Jul 2002-Farmaco
TL;DR: This review discusses the optimization of HPLC conditions for the chiral resolution of racemic drugs on polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases (CSPs).
Abstract: The chiral resolution by high performance liquid chromatography (HPLC) is controlled by a number of parameters. The optimization of HPLC parameters is an important issue in chiral resolution. This review discusses the optimization of HPLC conditions for the chiral resolution of racemic drugs on polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases (CSPs). The most important parameters discussed are composition of mobile phase, pH of mobile phase, flow rate, temperature and effect of other parameters.

100 citations


Authors

Showing all 58 results

NameH-indexPapersCitations
Hassan Y. Aboul-Enein5687616492
Roger W. Byard54100216437
Shahrukh K. Hashmi332684176
Ashraf Ghanem321173166
Abderrezak Bouchama31705690
Pinar Ozand261602273
Claire Simons23902018
Asim F. Belgaumi16541009
Saeed Ahmed1667716
Christer Ullbro1322746
Imran Ali1336848
Gael E. Phillips1324629
J. Brismar1112356
Tariq Ali11151704
Yunus M. Siddiqui1115445
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20212
20201
20191
20171
20161
20142