King Faisal Specialist Hospital & Research Centre

About: King Faisal Specialist Hospital & Research Centre is a(n) healthcare organization based out in Riyadh, Saudi Arabia. It is known for research contribution in the topic(s): Detection limit & High-performance liquid chromatography. The organization has 58 authors who have published 157 publication(s) receiving 3527 citation(s).

Lipase-mediated chiral resolution of racemates in organic solvents

Abstract: Lipase-catalyzed kinetic resolution of racemates is considered to be one of the most fascinating topics in asymmetric catalysis. This review focuses on some of the recent developments in this rapidly growing field demonstrating the versatility of the method in the resolution of racemates. The literature search is dated back to the last five years and covers some comprehensive examples. The main emphasis is on the use of lipases in organic solvents.

Application of lipases in kinetic resolution of racemates.

Abstract: Lipases have been well established as valuable catalysts in organic synthesis This review article focuses on some of the recent developments in the rapidly growing field of lipase-catalyzed kinetic resolution of racemates as a versatile method for the separation of enantiomers The literature search dates back to the last five years and covers some comprehensive examples The main emphasis is on the use of lipases in organic solvents

Speciation of arsenic and chromium metal ions by reversed phase high performance liquid chromatography.

Abstract: The speciation of arsenic [As(III) and As(V)] and chromium [Cr(III) and Cr(VI)] was carried out by high performance liquid chromatography. The column used was Econosil C18 (250×4.6 mm i.d., particle size 10 μ m). The mobile phases consisted of water–acetonitrile (80:20, v/v) for arsenic and 10 mM ammonium acetate buffer (6.0 pH)–acetonitrile (10:90, v/v) for chromium speciation separately and respectively. The detection was carried out by UV–Vis at 410 nm and atomic absorption spectrometer (AAS) respectively and separately. The values of α and Rs of As(III) and As(V) species were 1.4 and 1.5 respectively while the values of α and Rs for Cr(III) and Cr(VI) were 1.35 and 0.2 respectively. The effect of the acetonitrile percentages was also carried out on the speciation of arsenic only. The relative standard deviation and limit of detection were in the range of 0.01–0.02 and 0.4– 1.0 μ g/ml respectively.

High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on polysaccharide-type chiral stationary phases.

Abstract: Enantioseparation of drugs with multiple chiral centers is challenging. This article describes resolution of some drugs with multiple chiral centers using polysaccharide-type chiral stationary phases. Also, the use of the column-switching technique is demonstrated to achieve the resolution of this type of compounds.

Optimization strategies for HPLC enantioseparation of racemic drugs using polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases

Abstract: The chiral resolution by high performance liquid chromatography (HPLC) is controlled by a number of parameters. The optimization of HPLC parameters is an important issue in chiral resolution. This review discusses the optimization of HPLC conditions for the chiral resolution of racemic drugs on polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases (CSPs). The most important parameters discussed are composition of mobile phase, pH of mobile phase, flow rate, temperature and effect of other parameters.