Institution
King Faisal Specialist Hospital & Research Centre
Healthcare•Riyadh, Saudi Arabia•
About: King Faisal Specialist Hospital & Research Centre is a healthcare organization based out in Riyadh, Saudi Arabia. It is known for research contribution in the topics: Detection limit & High-performance liquid chromatography. The organization has 58 authors who have published 157 publications receiving 3527 citations.
Topics: Detection limit, High-performance liquid chromatography, Chiral resolution, Enantiomer, Medicine
Papers published on a yearly basis
Papers
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TL;DR: The capillary electrophoretic behavior and the determination of fluvastatin (FLU) in capsule and serum is described in this study and a good electropherogram and excellent repeatability was obtained.
Abstract: The capillary electrophoretic behavior and the determination of fluvastatin (FLU) in capsule and serum is described in this study. Method development was conducted in a fused-silica capillary (L = 86 cm, Leff = 58 cm and 75 µm i.d.) and a background electrolyte consisting of 10 mM borate at pH 8 was used. The separation was performed by current-controlled system applying 41 µA, detecting at 239 nm and injecting 0.5 s vacuum injection. A good electropherogram and excellent repeatability was obtained. FLU and phenobarbital sodium (internal standard) migrated (with RSD%) at 4.8 (0.3) min and 5.2 (0.6) min, respectively. Limit of detection (LOD) and limit of quantitation (LOQ) values were found to be 1 × 10−6 M and 2.89 × 10−6 M, respectively. Linearity in the range of 1.03 × 10−5 –5.15 × 10−5 M was examined employing intra-day and inter-day studies and well-correlated calibration equations were obtained. FLU in a capsule (Lescol® 40 mg declared) was found to be 41.9 ± 0.4 mg. Furthermore, FLU was determined in serum applying standard addition technique. Good repeatability and no interference were observed. The method proposed is simple, sensitive, precise and easy to use for the determination of FLU in capsule and serum. Copyright © 2001 John Wiley & Sons, Ltd.
Abbreviations used:
FLU
fluvastatin
HMG-CoA
hydroxymethylglutaryl coenzyme
17 citations
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TL;DR: The enantiomeric separation of some nonsteroidal antiinflammatory drugs was investigated on an avidin column and revealed that the organic modifier concentration and sometimes the pH are significant parameters to control because of their influence on both analysis time and resolution.
16 citations
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TL;DR: An enantioseparation high performance liquid chromatographic (HPLC) method was developed and validated to determine D-(+)- and L-(-)-vesamicol in human plasma and proved to be precise and accurate.
16 citations
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TL;DR: A simple HPLC analysis for the ide.gification and qua. gification of vardenafil in a pharmaceutical tablet formulation was performed on a conventional C18 and Chromolith Performance RP•18e monolith in this article.
Abstract: A simple HPLC analysis for the ide.gification and qua.gification of vardenafil in a pharmaceutical tablet formulation was performed on a conventional C18 and Chromolith Performance RP‐18e monolithi...
16 citations
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TL;DR: In this paper, the analysis of four trace elements (Cu, Zn, Cd, and Ni) in cows, goats, ewes, and human mature milk collected in Tokat, Turkey was carried out by flame atomic absorption spectrometry (FAAS) and microwave digestion technique method, which was used to extract the trace elements from the milk samples.
Abstract: Recently, several studies have been reported on the trace element composition of milk, especially human milk. However, there is limited study comparing different types of milk collected from different animals and humans. This study describes the analysis of four trace elements (Cu, Zn, Cd, and Ni) in cows', goats', ewes', and human mature milk collected in Tokat, Turkey. Analysis was carried out by flame atomic absorption spectrometry (FAAS) and microwave digestion technique method, which was used to extract the trace elements from the milk samples. Our results are in agreement with the values reported in the literature, with the exception of nickel concentration in ewes' milk, which has the highest value reported.
16 citations
Authors
Showing all 81 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hassan Y. Aboul-Enein | 56 | 876 | 16492 |
Roger W. Byard | 54 | 1002 | 16437 |
Shahrukh K. Hashmi | 33 | 268 | 4176 |
Ashraf Ghanem | 32 | 117 | 3166 |
Abderrezak Bouchama | 31 | 70 | 5690 |
Pinar Ozand | 26 | 160 | 2273 |
Claire Simons | 23 | 90 | 2018 |
Asim F. Belgaumi | 16 | 54 | 1009 |
Saeed Ahmed | 16 | 67 | 716 |
Christer Ullbro | 13 | 22 | 746 |
Imran Ali | 13 | 36 | 848 |
Gael E. Phillips | 13 | 24 | 629 |
J. Brismar | 11 | 12 | 356 |
Tariq Ali | 11 | 15 | 1704 |
Yunus M. Siddiqui | 11 | 15 | 445 |