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Institution

King Faisal Specialist Hospital & Research Centre

HealthcareRiyadh, Saudi Arabia
About: King Faisal Specialist Hospital & Research Centre is a healthcare organization based out in Riyadh, Saudi Arabia. It is known for research contribution in the topics: Detection limit & High-performance liquid chromatography. The organization has 58 authors who have published 157 publications receiving 3527 citations.


Papers
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Journal ArticleDOI
TL;DR: The capillary electrophoretic behavior and the determination of fluvastatin (FLU) in capsule and serum is described in this study and a good electropherogram and excellent repeatability was obtained.
Abstract: The capillary electrophoretic behavior and the determination of fluvastatin (FLU) in capsule and serum is described in this study. Method development was conducted in a fused-silica capillary (L = 86 cm, Leff = 58 cm and 75 µm i.d.) and a background electrolyte consisting of 10 mM borate at pH 8 was used. The separation was performed by current-controlled system applying 41 µA, detecting at 239 nm and injecting 0.5 s vacuum injection. A good electropherogram and excellent repeatability was obtained. FLU and phenobarbital sodium (internal standard) migrated (with RSD%) at 4.8 (0.3) min and 5.2 (0.6) min, respectively. Limit of detection (LOD) and limit of quantitation (LOQ) values were found to be 1 × 10−6 M and 2.89 × 10−6 M, respectively. Linearity in the range of 1.03 × 10−5 –5.15 × 10−5 M was examined employing intra-day and inter-day studies and well-correlated calibration equations were obtained. FLU in a capsule (Lescol® 40 mg declared) was found to be 41.9 ± 0.4 mg. Furthermore, FLU was determined in serum applying standard addition technique. Good repeatability and no interference were observed. The method proposed is simple, sensitive, precise and easy to use for the determination of FLU in capsule and serum. Copyright © 2001 John Wiley & Sons, Ltd. Abbreviations used: FLU fluvastatin HMG-CoA hydroxymethylglutaryl coenzyme

17 citations

Journal ArticleDOI
TL;DR: The enantiomeric separation of some nonsteroidal antiinflammatory drugs was investigated on an avidin column and revealed that the organic modifier concentration and sometimes the pH are significant parameters to control because of their influence on both analysis time and resolution.

16 citations

Journal ArticleDOI
TL;DR: An enantioseparation high performance liquid chromatographic (HPLC) method was developed and validated to determine D-(+)- and L-(-)-vesamicol in human plasma and proved to be precise and accurate.

16 citations

Journal ArticleDOI
TL;DR: A simple HPLC analysis for the ide.gification and qua. gification of vardenafil in a pharmaceutical tablet formulation was performed on a conventional C18 and Chromolith Performance RP•18e monolith in this article.
Abstract: A simple HPLC analysis for the ide.gification and qua.gification of vardenafil in a pharmaceutical tablet formulation was performed on a conventional C18 and Chromolith Performance RP‐18e monolithi...

16 citations

Journal ArticleDOI
TL;DR: In this paper, the analysis of four trace elements (Cu, Zn, Cd, and Ni) in cows, goats, ewes, and human mature milk collected in Tokat, Turkey was carried out by flame atomic absorption spectrometry (FAAS) and microwave digestion technique method, which was used to extract the trace elements from the milk samples.
Abstract: Recently, several studies have been reported on the trace element composition of milk, especially human milk. However, there is limited study comparing different types of milk collected from different animals and humans. This study describes the analysis of four trace elements (Cu, Zn, Cd, and Ni) in cows', goats', ewes', and human mature milk collected in Tokat, Turkey. Analysis was carried out by flame atomic absorption spectrometry (FAAS) and microwave digestion technique method, which was used to extract the trace elements from the milk samples. Our results are in agreement with the values reported in the literature, with the exception of nickel concentration in ewes' milk, which has the highest value reported.

16 citations


Authors

Showing all 81 results

NameH-indexPapersCitations
Hassan Y. Aboul-Enein5687616492
Roger W. Byard54100216437
Shahrukh K. Hashmi332684176
Ashraf Ghanem321173166
Abderrezak Bouchama31705690
Pinar Ozand261602273
Claire Simons23902018
Asim F. Belgaumi16541009
Saeed Ahmed1667716
Christer Ullbro1322746
Imran Ali1336848
Gael E. Phillips1324629
J. Brismar1112356
Tariq Ali11151704
Yunus M. Siddiqui1115445
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202312
202226
20213
20201
20191
20171