King Faisal Specialist Hospital & Research Centre

About: King Faisal Specialist Hospital & Research Centre is a healthcare organization based out in Riyadh, Saudi Arabia. It is known for research contribution in the topics: Detection limit & High-performance liquid chromatography. The organization has 58 authors who have published 157 publications receiving 3527 citations.

Toward Zero Harm: Mackenzie Health’s Journey Toward Becoming a High Reliability Organization and Eliminating Avoidable Harm

Abstract: In response to an organizational survey revealing low safety culture scores, we implemented a "zero harm" approach to eliminate preventable harm across a wide variety of clinical areas. We aimed to achieve this objective within 3 years.We developed a 5-part strategy for cultural and process redesign that included (1) engaging leadership; (2) developing an organization-specific patient safety framework; (3) monitoring specific quality aims based on high-risk, high-volume, high-cost, and problem-prone areas; (4) standardizing a 3-part review process that includes a root cause analysis for moderate and critical patient safety incidents; and (5) communicating progress to staff in real time via unit-specific electronic dashboards.In less than 1 year, we increased patient safety incident reporting by 37% while simultaneously decreasing falls with injury by 39%, pressure injury rates by 37%, and central line-associated blood stream infections by 34%. We also improved medication reconciliation rate by 3.3% and decreased our irretrievable specimen rate to 0. Finally, we noted increased awareness around patient safety within clinical teams, with open discussions about patient safety becoming a routine part of patient care.This study describes an initiative that sought to introduce system-wide changes to practice and patient safety culture in a rapid time frame. Results suggest that our 5-step approach to transformation may confer substantial gains in patient safety for peer institutions. Next steps include continuing to expand and monitor quality aims as we progress through our journey to eliminating preventable patient harm in our healthcare system.

HPLC analysis of S-adenosyl-L-methionine in pharmaceutical formulations

Abstract: A validated analytical method of S-adenosyl-L-methionine (SAM) in pharmaceutical preparations by reversed phase high performance liquid chromatography (RP-HPLC) is described. The compound is separated by a 2.1 mm x 15 cm, 5 microns--Discovery C18 column with isocratic elution. The effect of different anionic surface active agents with different molarity on the separation was studied. A direct relationship between the molarity of the surface active agents and the capacity factor (k') was found. The limit of detection was 0.49 mmol/ml and the linearity was r = 0.999 in the concentration range 20-100 micrograms/ml. Inter- and intra-assay variation was determined for three selected concentrations (20, 60, 100 micrograms/ml) by calculating the analytical recoveries with a range of 97.0-99.9%. The procedure was also suitable to check the stability of S-adenosyl-L-methionine in solution at room temperature.

Prenatal Diagnosis of Ductus Arteriosus Aneurysm: A Case Report and Literature Review

Abstract: Abstract The ductus arteriosus (DA) is a vascular shunt between the main pulmonary artery and the proximal descending aorta, allowing the oxygenated blood from the placenta to bypass the fetal pulmonary circulation and supply oxygen-rich blood to the systemic circulation. Anomalies within the ductus arteriosus can compromise fetal circulation. Ductus arteriosus aneurysm (DAA) is a localized saccular or tubular dilation of the DA and is considered a rare lesion. However, many reports in the literature describe DAA in the infancy period, with limited reports describing the lesion prenatally. We diagnosed a case of ductus arteriosus aneurysm with mild hypoplasia of the transverse arch prenatally at a 37-week gestational age. Both resolved spontaneously in the third week of life without complication.