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Institution

King Hussein Cancer Center

NonprofitAmman, Jordan
About: King Hussein Cancer Center is a nonprofit organization based out in Amman, Jordan. It is known for research contribution in the topics: Cancer & Breast cancer. The organization has 849 authors who have published 866 publications receiving 12429 citations.


Papers
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Journal ArticleDOI
TL;DR: This review provides an objective and comprehensive account of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes.
Abstract: Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell–cell communication, and modulate cell structure in a manner dictated largely by phenomena at the nano–bio interface. Recent advances in chemical synthesis have yielded new nanoscale materials with precisely defined biochemical features, and emerging analytical techniques have shed light on nuanced and context-dependent nano-bio interactions within cells. In this review, we provide an objective and comprehensive account of our current understanding of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes.

1,498 citations

Journal ArticleDOI
TL;DR: This article analyzes the interaction of nanoparticle surface and ligands with different chemical groups, the types of bonding, the final dispersibility of ligand-coated nanoparticles in complex media, their reactivity, and their performance in biomedicine, photodetectors, photovoltaic devices, light-emitting devices, sensors, memory devices, thermoelectric applications, and catalysis.
Abstract: The design of nanoparticles is critical for their efficient use in many applications ranging from biomedicine to sensing and energy. While shape and size are responsible for the properties of the inorganic nanoparticle core, the choice of ligands is of utmost importance for the colloidal stability and function of the nanoparticles. Moreover, the selection of ligands employed in nanoparticle synthesis can determine their final size and shape. Ligands added after nanoparticle synthesis infer both new properties as well as provide enhanced colloidal stability. In this article, we provide a comprehensive review on the role of the ligands with respect to the nanoparticle morphology, stability, and function. We analyze the interaction of nanoparticle surface and ligands with different chemical groups, the types of bonding, the final dispersibility of ligand-coated nanoparticles in complex media, their reactivity, and their performance in biomedicine, photodetectors, photovoltaic devices, light-emitting devices, sensors, memory devices, thermoelectric applications, and catalysis.

616 citations

Journal ArticleDOI
Stella G. Muthuri1, Sudhir Venkatesan1, Puja R. Myles1, Jo Leonardi-Bee1, Tarig Saleh Al Khuwaitir2, Adbullah Al Mamun3, Ashish P Anovadiya4, Eduardo Azziz-Baumgartner5, Clarisa Báez, Matteo Bassetti, Bojana Beović6, Barbara Bertisch7, Isabelle Bonmarin8, Robert Booy9, Víctor Hugo Borja-Aburto10, Heinz Burgmann11, Bin Cao12, Jordi Carratalà13, Justin T Denholm, Samuel R. Dominguez14, Péricles Almeida Delfino Duarte15, Gal Dubnov-Raz16, Marcela Echavarria, Sergio Fanella17, Zhancheng Gao18, Patrick Gérardin19, Maddalena Giannella20, Sophie Gubbels21, Jethro Herberg22, A. Iglesias, Peter Höger23, Xiaoyun Hu24, Quazi Tarikul Islam25, Mirela Foresti Jiménez26, Amr Kandeel, Gerben Keijzers27, Hossein Khalili28, Marian Knight29, Koichiro Kudo, Gabriela Kusznierz, Ilija Kuzman30, Arthur M C Kwan31, Idriss Lahlou Amine, Eduard Langenegger32, Kamran Bagheri Lankarani33, Yee-Sin Leo34, Rita Linko35, Pei Liu36, Faris Madanat37, Elga Mayo-Montero, Allison McGeer38, Ziad A. Memish39, Gökhan Metan40, Auksė Mickiene41, Dragan Mikić42, Kristin G.-I. Mohn43, Kristin G.-I. Mohn44, Ahmadreza Moradi45, Ahmadreza Moradi46, Pagbajabyn Nymadawa, Maria E. Oliva, Mehpare Ozkan, Dhruv Parekh47, Mical Paul48, Fernando P. Polack49, Barbara Rath50, Alejandro Rodríguez, Elena B. Sarrouf, Anna C. Seale51, Anna C. Seale23, Bunyamin Sertogullarindan52, Marilda M. Siqueira53, Joanna Skręt-Magierło54, Frank P. Stephan55, Ewa Talarek56, Julian W. Tang57, Julian W. Tang58, Kelvin K. W. To59, Antoni Torres13, Selda Hançerli Törün, Dat Tran38, Timothy M. Uyeki60, Annelies van Zwol61, Wendy Vaudry58, Tjasa Vidmar, Renata T. C. Yokota, Paul Zarogoulidis, Jonathan S. Nguyen-Van-Tam1 
University of Nottingham1, King Saud Medical City2, International Centre for Diarrhoeal Disease Research, Bangladesh3, Government Medical College, Thiruvananthapuram4, Centers for Disease Control and Prevention5, Ljubljana University Medical Centre6, Kantonsspital St. Gallen7, Institut de veille sanitaire8, Children's Hospital at Westmead9, Mexican Social Security Institute10, Medical University of Vienna11, Capital Medical University12, University of Barcelona13, University of Colorado Denver14, State University of West Paraná15, Sheba Medical Center16, University of Manitoba17, Peking University18, National Institutes of Health19, Hospital General Universitario Gregorio Marañón20, Statens Serum Institut21, Imperial College London22, Boston Children's Hospital23, Peking Union Medical College Hospital24, Dhaka Medical College and Hospital25, Universidade Federal de Ciências da Saúde de Porto Alegre26, Gold Coast Hospital27, Tehran University of Medical Sciences28, University of Oxford29, University of Zagreb30, Pamela Youde Nethersole Eastern Hospital31, Stellenbosch University32, Shiraz University of Medical Sciences33, Tan Tock Seng Hospital34, University of Helsinki35, China Medical University (PRC)36, King Hussein Cancer Center37, University of Toronto38, Alfaisal University39, Erciyes University40, Lithuanian University of Health Sciences41, Military Medical Academy42, University of Bergen43, Haukeland University Hospital44, Johns Hopkins University School of Medicine45, Shahid Beheshti University of Medical Sciences and Health Services46, University of Birmingham47, Rambam Health Care Campus48, Vanderbilt University49, Charité50, University of Bristol51, Yüzüncü Yıl University52, Oswaldo Cruz Foundation53, Rzeszów University54, University Hospital of Basel55, Medical University of Warsaw56, University of Alberta Hospital57, University of Alberta58, University of Hong Kong59, National Center for Immunization and Respiratory Diseases60, VU University Medical Center61
TL;DR: There was an increase in the mortality hazard rate with each day's delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset, and early treatment versus no treatment was also associated with a reduction in mortality risk.

527 citations

Journal ArticleDOI
TL;DR: Multivariate analysis showed that age, histologic subtype, primary site location, stage, and local control with surgery and/or radiation were significant predictors of survival, however, alveolar subtype and unfavorable primary site lost significance when analysis was restricted to adults.
Abstract: Purpose To compare clinical features and outcomes of adults and children reported to have rhabdomyosarcoma. Patients and methods We analyzed data from 1,071 adults (age > 19 years) and 1,529 children (age Results Adults with rhabdomyosarcoma had significantly worse outcome than children (5-year overall survival rates, 27% +/- 1.4% and 61% +/- 1.4%, respectively; P Conclusion Adults reported to have rhabdomyosarcoma had worse survival than children with similar tumors. Predictors of poor outcome in children were valid in adults except for alveolar histology and unfavorable tumor site.

352 citations


Authors

Showing all 860 results

NameH-indexPapersCitations
Lawrence M. Pfeffer5520211010
Ahmed Salem382716477
Ibrahim Qaddoumi341495041
Robert Rejdak262772483
Iyad Sultan251014195
Osama Alsmadi23811929
Suleiman Massarweh21494037
Mohammed Odeh2011214152
Maysa Al-Hussaini171151188
Maher A. Sughayer17751062
Mario Damiano Toro1793883
Abdelghani Tbakhi16721028
Feras Hawari16621414
Asem Mansour1564790
Hikmat Abdel-Razeq1490763
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20233
202211
2021166
2020128
201992
201884