Institution
Korea Research Institute of Bioscience and Biotechnology
Facility•Daejeon, South Korea•
About: Korea Research Institute of Bioscience and Biotechnology is a facility organization based out in Daejeon, South Korea. It is known for research contribution in the topics: Gene & Cancer cell. The organization has 6616 authors who have published 9900 publications receiving 264488 citations. The organization is also known as: KRIBB.
Topics: Gene, Cancer cell, Cancer, Signal transduction, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: A high-quality genome sequence of domesticated tomato is presented, a draft sequence of its closest wild relative, Solanum pimpinellifolium, is compared, and the two tomato genomes are compared to each other and to the potato genome.
Abstract: Tomato (Solanum lycopersicum) is a major crop plant and a model system for fruit development. Solanum is one of the largest angiosperm genera1 and includes annual and perennial plants from diverse habitats. Here we present a high-quality genome sequence of domesticated tomato, a draft sequence of its closest wild relative, Solanum pimpinellifolium2, and compare them to each other and to the potato genome (Solanum tuberosum). The two tomato genomes show only 0.6% nucleotide divergence and signs of recent admixture, but show more than 8% divergence from potato, with nine large and several smaller inversions. In contrast to Arabidopsis, but similar to soybean, tomato and potato small RNAs map predominantly to gene-rich chromosomal regions, including gene promoters. The Solanum lineage has experienced two consecutive genome triplications: one that is ancient and shared with rosids, and a more recent one. These triplications set the stage for the neofunctionalization of genes controlling fruit characteristics, such as colour and fleshiness.
2,687 citations
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TL;DR: The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1β in the pathogenesis of type 2 diabetes.
Abstract: The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated inflammasome activity is associated with several inflammatory diseases, yet little is known about the signaling pathways that lead to its activation. Here we show that NLRP3 interacted with thioredoxin (TRX)-interacting protein (TXNIP), a protein linked to insulin resistance. Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3. TXNIP deficiency impaired activation of the NLRP3 inflammasome and subsequent secretion of interleukin 1beta (IL-1beta). Akin to Txnip(-/-) mice, Nlrp3(-/-) mice showed improved glucose tolerance and insulin sensitivity. The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1beta in the pathogenesis of type 2 diabetes.
2,123 citations
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TL;DR: PGPR might also increase nutrient uptake from soils, thus reducing the need for fertilizers and preventing the accumulation of nitrates and phosphates in agricultural soils, and reduce the effects of water contamination from fertilizer run-off and lead to savings for farmers.
1,504 citations
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TL;DR: The microwave oven method was identified as the most simple, easy, and effective for lipid extraction from microalgae.
1,244 citations
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TL;DR: Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations, which is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial.
Abstract: The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations. Such clock-like regularity is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial. This same population later evolved an elevated mutation rate and accumulated hundreds of additional mutations dominated by a neutral signature. Thus, the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable.
1,165 citations
Authors
Showing all 6637 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jean Rivier | 133 | 769 | 73919 |
Nicholas A. Kotov | 123 | 574 | 55210 |
John Blenis | 105 | 236 | 57863 |
Ki-Hyun Kim | 99 | 1911 | 52157 |
Tae Gwan Park | 98 | 277 | 29385 |
David A. Stevens | 94 | 607 | 42566 |
Baldomero M. Olivera | 92 | 503 | 32064 |
Zigang Dong | 90 | 553 | 27370 |
Hyun Lee | 83 | 512 | 52596 |
Young Ho Kim | 82 | 2528 | 47681 |
Irwin D. Kuntz | 78 | 236 | 26163 |
Young-Min Kim | 71 | 1314 | 26916 |
Jongsik Chun | 65 | 289 | 29890 |
Yang-Kyu Choi | 65 | 617 | 19653 |
Dae-Jin Yun | 64 | 252 | 14599 |