Korea University

About: Korea University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Thin film. The organization has 39756 authors who have published 82424 publications receiving 1860927 citations. The organization is also known as: Bosung College & Bosung Professional College.

Optimal Duration of Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation A Randomized, Controlled Trial

Abstract: Background—The risks and benefits of long-term dual antiplatelet therapy remain unclear Methods and Results—This prospective, multicenter, open-label, randomized comparison trial was conducted in 24 clinical centers in Korea In total, 5045 patients who received drug-eluting stents and were free of major adverse cardiovascular events and major bleeding for at least 12 months after stent placement were enrolled between July 2007 and July 2011 Patients were randomized to receive aspirin alone (n=2514) or clopidogrel plus aspirin (n=2531) The primary end point was a composite of death resulting from cardiac causes, myocardial infarction, or stroke 24 months after randomization At 24 months, the primary end point occurred in 57 aspirin-alone group patients (24%) and 61 dual-therapy group patients (26%; hazard ratio, 094; 95% confidence interval, 066–135; P=075) The 2 groups did not differ significantly in terms of the individual risks of death resulting from any cause, myocardial infarction, stent

TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L).

Abstract: Reactive oxygen species (ROS) produced by tumor necrosis factor-alpha (TNF-alpha) have an important function in cell death by activating c-Jun N-terminal kinase. However, the exact mechanism of mitochondrial ROS production, after TNF-alpha stimulation, is not clearly understood. In this study, we determined that ROS modulator 1 (Romo1) and B-cell lymphoma-extra large (Bcl-X(L)) are directly associated with TNF-alpha-induced ROS production. In response to TNF-alpha, TNF complex II, which consists of receptor-interacting protein 1, TNF receptor-associated protein with death domain, TNF receptor-associated factor 2, Fas-associated death domain protein, and pro-caspase-8, binds to the C-terminus of Romo1 located in the mitochondria. Concurrently, Romo1 recruits Bcl-X(L) to reduce the mitochondrial membrane potential, resulting in ROS production and apoptotic cell death. On the basis of these results, we suggest that Romo1 is a molecular bridge between TNF-alpha signaling and the mitochondria for ROS production that triggers TNF-alpha-mediated apoptosis, as well as a novel target in the development of anti-inflammatory agents that block the origin of ROS production.