Institution
Kresge Hearing Research Institute
About: Kresge Hearing Research Institute is a based out in . It is known for research contribution in the topics: Cochlea & Organ of Corti. The organization has 310 authors who have published 549 publications receiving 26770 citations.
Topics: Cochlea, Organ of Corti, Inner ear, Hair cell, Hearing loss
Papers published on a yearly basis
Papers
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TL;DR: It is reported that Atoh1, a gene also known as Math1 encoding a basic helix-loop-helix transcription factor and key regulator of hair cell development, induces regeneration of hair cells and substantially improves hearing thresholds in the mature deaf inner ear after delivery to nonsensory cells through adenovectors.
Abstract: In the mammalian auditory system, sensory cell loss resulting from aging, ototoxic drugs, infections, overstimulation and other causes is irreversible and leads to permanent sensorineural hearing loss. To restore hearing, it is necessary to generate new functional hair cells. One potential way to regenerate hair cells is to induce a phenotypic transdifferentiation of nonsensory cells that remain in the deaf cochlea. Here we report that Atoh1, a gene also known as Math1 encoding a basic helix-loop-helix transcription factor and key regulator of hair cell development, induces regeneration of hair cells and substantially improves hearing thresholds in the mature deaf inner ear after delivery to nonsensory cells through adenovectors. This is the first demonstration of cellular and functional repair in the organ of Corti of a mature deaf mammal. The data suggest a new therapeutic approach based on expressing crucial developmental genes for cellular and functional restoration in the damaged auditory epithelium and other sensory systems.
665 citations
TL;DR: Significantly more neurofilament positive staining was found on the coated electrode which indicated that the coatings had established strong connections with the neuronal structure in vivo.
506 citations
TL;DR: An infant with localized bronchial malacia was treated with a computer-printed bioresorbable three-dimensional splint and placement of the splint resulted in improved ventilation.
Abstract: An infant with localized bronchial malacia was treated with a computer-printed bioresorbable three-dimensional splint. Placement of the splint resulted in improved ventilation.
502 citations
TL;DR: Investigating the survival capacity of isolated outer hair cells and strips dissected from different turns of the guinea pig organ of Corti supported an intrinsic susceptibility to free radicals that differs among cochlear cell populations, providing a rational explanation for base-to-apex gradients observed in various forms of co chlear pathology.
367 citations
TL;DR: Interventions are identified that prevent noise-induced hearing loss, even with treatment onset delayed up to 3 days post-noise, and the additive effects of agents intervening at different points in the cell death pathway are assessed to optimize treatment efficacy.
355 citations
Authors
Showing all 310 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Michael Brenner | 76 | 564 | 22010 |
| Thomas E. Carey | 71 | 350 | 21851 |
| Li Xu | 68 | 965 | 22024 |
| Jochen Schacht | 64 | 252 | 12655 |
| Yehoash Raphael | 57 | 183 | 10835 |
| Josef M. Miller | 55 | 231 | 10398 |
| Richard A. Altschuler | 52 | 169 | 9044 |
| Alfred L. Nuttall | 50 | 264 | 7944 |
| Stephen C. Cannon | 50 | 121 | 7876 |
| Tatsuya Yamasoba | 50 | 507 | 11765 |
| John C. Middlebrooks | 48 | 107 | 8805 |
| Steven A. Telian | 44 | 136 | 5178 |
| Bryan E. Pfingst | 41 | 119 | 4344 |
| Susan E. Shore | 41 | 84 | 4574 |
| Gabriel Corfas | 39 | 76 | 4563 |