Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Population, Cancer, Cell culture, Stem cell, Cellular differentiation
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that distal visceral endoderm cells move to the future anterior side to generate a prospective forebrain territory indirectly, by preventing posteriorizing signals.
222 citations
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TL;DR: This work shows that Wnt5a and its receptor Ror2 are expressed in a graded manner along the AP axis of the palate, and reveals distinct regulatory roles for Wnt 5a in gene expression and cell proliferation and an essential role in the regulation of directional cell migration within the developing palate.
Abstract: Tissue and molecular heterogeneities are present in the developing
secondary palate along the anteroposterior (AP) axis in mice. Here, we show
that Wnt5a and its receptor Ror2 are expressed in a graded manner along the AP
axis of the palate. Wnt5a deficiency leads to a complete cleft of the
secondary palate, which exhibits distinct phenotypic alterations at
histological, cellular and molecular levels in the anterior and posterior
regions of the palate. We demonstrate that there is directional cell migration
within the developing palate. In the absence of Wnt5a, this
directional cell migration does not occur. Genetic studies and in vitro organ
culture assays further demonstrate a role for Ror2 in mediating Wnt5a
signaling in the regulation of cell proliferation and migration during palate
development. Our results reveal distinct regulatory roles for Wnt5a in gene
expression and cell proliferation along the AP axis of the developing palate,
and an essential role for Wnt5a in the regulation of directional cell
migration.
221 citations
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TL;DR: Inhibition of AURKA expression can result in potent antitumor activity and chemosensitizing activity to taxanes in human pancreatic cancer, and a synergistic enhancement of the cytotoxicity of taxanes is observed by the RNA interference-mediated knockdown.
Abstract: AURKA/STK15/BTAK , the gene encoding Aurora A kinase that is involved in the regulation of centrosomes and segregation of chromosomes, is frequently amplified and overexpressed in various kinds of human cancers, including pancreatic cancer. To address its possibility as a therapeutic target for pancreatic cancer, we employed the RNA interference technique to knockdown AURKA expression and analyzed its phenotypes. We found that the specific knockdown of AURKA in cultured pancreatic cancer cells strongly suppressed in vitro cell growth and in vivo tumorigenicity. The knockdown induced the accumulation of cells in the G2-M phase and eventual apoptosis. Furthermore, we observed a synergistic enhancement of the cytotoxicity of taxanes, a group of chemotherapeutic agents impairing G2-M transition, by the RNA interference–mediated knockdown of AURKA . These results indicate that inhibition of AURKA expression can result in potent antitumor activity and chemosensitizing activity to taxanes in human pancreatic cancer.
221 citations
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TL;DR: In this paper, a prospective method to install acoustic sensors into the rock slope (WEAD) is developed, based on the experimental results, the criteria for classifying fracture states are proposed, applying the criteria to the field data, fracture states estimated are compared with internal slope behavior evaluated from the displacement, borehole-strain, temperature and so forth.
221 citations
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TL;DR: It is suggested that APC prevented LPS-induced pulmonary vascular injury by inhibiting TNF production by monocytes and not via its anticoagulant activity, and the serine protease activity of APC appears to be essential for inhibition of TNFProduction.
Abstract: We investigated the effect of activated protein C (APC) on pulmonary vascular injury and the increase in tumor necrosis factor (TNF) levels in lipopolysaccharide (LPS)-treated rats to determine whe...
221 citations
Authors
Showing all 19645 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fred H. Gage | 216 | 967 | 185732 |
George D. Yancopoulos | 158 | 496 | 93955 |
Kenji Kangawa | 153 | 1117 | 110059 |
Tasuku Honjo | 141 | 712 | 88428 |
Hideo Yagita | 137 | 946 | 70623 |
Masashi Yanagisawa | 130 | 524 | 83631 |
Kazuwa Nakao | 128 | 1041 | 70812 |
Kouji Matsushima | 124 | 590 | 56995 |
Thomas E. Mallouk | 122 | 549 | 52593 |
Toshio Hirano | 120 | 401 | 55721 |
Eisuke Nishida | 112 | 349 | 45918 |
Hiroaki Shimokawa | 111 | 949 | 48822 |
Bernd Bukau | 111 | 271 | 38446 |
Kazuo Tsubota | 105 | 1379 | 48991 |
Toshio Suda | 104 | 580 | 41069 |