Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Population, Cancer, Cell culture, Stem cell, Cellular differentiation
Papers published on a yearly basis
Papers
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TL;DR: In this paper, two high-resolution cores from the continental slope of the eastern East China Sea (ECS) were used to reconstruct the surface-water history, showing that the planktic foraminiferal assemblage during the deglacial stage which is represented by high percentages of G. quinqueloba, is quite different from those during the glacial and postglacial stages.
214 citations
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TL;DR: This work visualized the subcellular distribution of mini-F-plasmid molecules by fluorescence in situ hybridization and found that molecules of a mini F plasmid lacking the sopABC segment were distributed randomly in spaces not occupied by nucleoids.
214 citations
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Kanazawa University1, Yokohama City University2, Nagoya University3, Okayama University4, Jikei University School of Medicine5, Chiba University6, Nagasaki University7, Mie University8, Jichi Medical University9, Osaka City University10, Kyoto Prefectural University of Medicine11, St. Marianna University School of Medicine12, Saitama Medical University13, Tokyo Medical University14, Kumamoto University15, Gunma University16, Hamamatsu University School of Medicine17
TL;DR: High-dose daunorubsicin and standard-dose idarubicin were equally effective for the treatment of adult acute myeloid leukemia, achieving a high rate of complete remission and good long-term efficacy.
214 citations
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03 Jun 2009TL;DR: A review of the literature on driver inattention monitoring system for the purpose of active safe driving can be found in this paper, where the authors classified driving inattentions into two categories: fatigue and distraction.
Abstract: This paper gives a review of the literature on driver inattention monitoring system for the purpose of active safe driving. In this paper driving inattention is classified into two categories: fatigue and distraction, while fatigue and distraction can also contain many types and levels. Individual difference on inattention phenomenon makes it more complicated to correctly detect and recognize driving inattention. Driver attention monitoring has been intensively researched in recent years and many approaches have been proposed, which include biological signal (EEG, ECG, EOG and sEMG) processing method, subjective report method, and behavior analysis method. This survey reviews a number of promising approaches and provides an overview of recent developments in this domain. The emphasis of this paper is to discuss the various methodologies to monitor driving inattention. We conclude with some thoughts about future directions.
214 citations
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TL;DR: Homology search for the amino acid sequence of the IL‐5 receptor reveals that the IL-5 receptor contains a common motif of a cytokine receptor family that is recently identified.
Abstract: Murine interleukin-5 (IL-5) is known to play an essential role in Ig production of B cells and proliferation and differentiation of eosinophils. Here, we have isolated cDNA clones encoding a murine IL-5 receptor by expression screening of a library prepared from a murine IL-5 dependent early B cell line. A cDNA library was expressed in COS7 cells and screened by panning with the use of anti-IL-5 receptor monoclonal antibodies. The deduced amino acid sequence analysis demonstrates that the receptor is a glycoprotein of 415 amino acids (Mr 45,284), including an N-terminal hydrophobic region (17 amino acids), a glycosylated extracellular domain (322 amino acids), a single transmembrane segment (22 amino acids) and a cytoplasmic tail (54 amino acids). COS7 cells transfected with the cDNA expressed a 60 kd protein that bound IL-5 with a single class of affinity (KD = 2-10 nM). FDC-P1 cells transfected with the cDNA for murine IL-5 receptor showed the expression of IL-5 binding sites with both low (KD = 6 nM) and high affinity (KD = 30 pM) and acquired responsiveness to IL-5 for proliferation, although parental FDC-P1 cells did not show any detectable IL-5 binding. In addition, several cDNA clones encoding soluble forms of the IL-5 receptor were isolated. Northern blot analysis showed that two species of mRNAs (5.0 kb and 5.8 kb) were detected in cell lines that display binding sites for murine IL-5. Homology search for the amino acid sequence of the IL-5 receptor reveals that the IL-5 receptor contains a common motif of a cytokine receptor family that is recently identified.
214 citations
Authors
Showing all 19645 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fred H. Gage | 216 | 967 | 185732 |
George D. Yancopoulos | 158 | 496 | 93955 |
Kenji Kangawa | 153 | 1117 | 110059 |
Tasuku Honjo | 141 | 712 | 88428 |
Hideo Yagita | 137 | 946 | 70623 |
Masashi Yanagisawa | 130 | 524 | 83631 |
Kazuwa Nakao | 128 | 1041 | 70812 |
Kouji Matsushima | 124 | 590 | 56995 |
Thomas E. Mallouk | 122 | 549 | 52593 |
Toshio Hirano | 120 | 401 | 55721 |
Eisuke Nishida | 112 | 349 | 45918 |
Hiroaki Shimokawa | 111 | 949 | 48822 |
Bernd Bukau | 111 | 271 | 38446 |
Kazuo Tsubota | 105 | 1379 | 48991 |
Toshio Suda | 104 | 580 | 41069 |