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Institution

Kumamoto University

EducationKumamoto, Kumamoto, Japan
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.


Papers
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Journal ArticleDOI
TL;DR: Using immunofluorescence microscopy, it is found that SeqA protein, a regulator of replication initiation, is localized as discrete fluorescent foci in E. coli wild-type cells and MukB protein is required for correct localization of SequA complexes by an unknown mechanism.

194 citations

Journal ArticleDOI
TL;DR: Results suggest that CSF‐1 derived from tumor tissues induces macrophages to shift toward the M2 phenotype, which is considered to promote tumor growth.
Abstract: Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to present results on macrophage differentiation in human ovarian serous and mucinous epithelial tumors. The method focused on immunostaining of paraffin-embedded tumor samples. Almost all macrophages infiltrating tumor tissues expressed CD163 and CD204, indicating the phenotypic shift toward M2 macrophage. The numbers of CD68-positive macrophages as well as of CD163- and CD204-positive macrophages in borderline and malignant tumors were significantly higher than in benign tumors. They correlated well with histological gradient of malignancy. Macrophage colony-stimulating factor (also known as colony-stimulating factor; CSF-1), which is one of the cytokines considered to induce TAM to polarize toward an M2 phenotype, was then evaluated. CSF-1 expression in malignant tumor cells was significantly higher than that in benign tumor cells and correlated with histological malignancy. These results suggest that CSF-1 derived from tumor tissues induces macrophages to shift toward the M2 phenotype, which is considered to promote tumor growth.

194 citations

Journal ArticleDOI
TL;DR: This is the first report of ubiquitous contamination and bioaccumulation of benzotriazole UV stabilizers in the marine environment and significant correlations were found between concentrations of UV stabilizer and organic carbon content in sediments, implying adsorption of these compounds to organic matter.
Abstract: The benzotriazole UV stabilizers, which are used in a variety of plastic products, were analyzed in marine organisms and sediments collected from the Ariake Sea, Japan. The UV stabilizers, such as UV-320, UV-326, UV-327, and UV-328 were detected in all of the samples analyzed, suggesting the production and use of these compounds in Japan. High concentrations of UV stabilizers were found in clams, oysters, and gastropods collected from the tidal flat at concentrations on the order of several hundreds of ng/g on a lipid weight (wt.) basis. The higher trophic species, such as hammerhead sharks and coastal birds, accumulated UV stabilizers, with mean concentrations of 190 ng/g and 74 ng/g (lipid wt.), respectively. These results indicate that benzotriazole UV stabilizers are persistent and bioaccumulative in the marine food-chains. The benzotriazole UV stabilizers were also detected in coastal and river sediments around the Ariake Sea, at concentrations in the range of 7.9-720 ng/g (dry weight basis). Significant correlations were found between concentrations of UV stabilizers and organic carbon content in sediments, implying adsorption of these compounds to organic matter. To our knowledge, this is the first report of ubiquitous contamination and bioaccumulation of benzotriazole UV stabilizers in the marine environment.

194 citations

Journal ArticleDOI
TL;DR: P purification of an endothelial cell growth inhibitor from a guanidine extract of bovine epiphyseal cartilage suggests a regulatory role of ChM-I in vascular invasion during endochondral bone formation.

193 citations


Authors

Showing all 19645 results

NameH-indexPapersCitations
Fred H. Gage216967185732
George D. Yancopoulos15849693955
Kenji Kangawa1531117110059
Tasuku Honjo14171288428
Hideo Yagita13794670623
Masashi Yanagisawa13052483631
Kazuwa Nakao128104170812
Kouji Matsushima12459056995
Thomas E. Mallouk12254952593
Toshio Hirano12040155721
Eisuke Nishida11234945918
Hiroaki Shimokawa11194948822
Bernd Bukau11127138446
Kazuo Tsubota105137948991
Toshio Suda10458041069
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
202297
20211,701
20201,654
20191,511
20181,330