Kumamoto University

About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Cancer & Population. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.

Reference values for spirometry, including vital capacity, in Japanese adults calculated with the LMS method and compared with previous values

Abstract: Background Reference values for lung function tests should be periodically updated because of birth cohort effects and improved technology. This study updates the spirometric reference values, including vital capacity (VC), for Japanese adults and compares the new reference values with previous Japanese reference values. Methods Spirometric data from healthy non-smokers (20,341 individuals aged 17–95 years, 67% females) were collected from 12 centers across Japan, and reference equations were derived using the LMS method. This method incorporates modeling skewness (lambda: L ), mean (mu: M ), and coefficient of variation (sigma: S ), which are functions of sex, age, and height. In addition, the age-specific lower limits of normal (LLN) were calculated. Results Spirometric reference values for the 17–95-year age range and the age-dependent LLN for Japanese adults were derived. The new reference values for FEV 1 in males are smaller, while those for VC and FVC in middle age and elderly males and those for FEV 1 , VC, and FVC in females are larger than the previous values. The LLN of the FEV 1 /FVC for females is larger than previous values. The FVC is significantly smaller than the VC in the elderly. Conclusions The new reference values faithfully reflect spirometric indices and provide an age-specific LLN for the 17–95-year age range, enabling improved diagnostic accuracy. Compared with previous prediction equations, they more accurately reflect the transition in pulmonary function during young adulthood. In elderly subjects, the FVC reference values are not interchangeable with the VC values.

Association of Remnant Lipoprotein Levels With Impairment of Endothelium-Dependent Vasomotor Function in Human Coronary Arteries

Abstract: Background—It remains undetermined whether triglyceride-rich lipoproteins are an independent risk factor for atherosclerosis. Methods and Results—The correlation of responses of coronary arterial d...