Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Population, Cancer, Cell culture, Stem cell, Cellular differentiation
Papers published on a yearly basis
Papers
More filters
TL;DR: The results strongly suggest that the process of intra‐marrow B cell development is controlled by more than one signal acting on different stages of B cell differentiation.
Abstract: B lymphopoiesis supporting activities of two stromal cell clones, MC3T3-G2/PA6 (PA6) and ST2, were compared. When normal bone marrow cells were cultured in these clones under Whitlock-Witte-type condition, mature B cells were generated only in the culture with the ST2 layer. The cells maintained on the PA6 layer, however, contained the precursor cells giving rise to mature B cells when transferred to the ST2 layer. Thus, PA6 is a stromal cell clone capable of supporting the early B progenitors but cannot support a further maturation step into pre-B cells. The immunoglobulin heavy chain gene configuration of B progenitors maintained on the PA6 layer diversified after their transfer onto ST2 layer. This suggests that they are actually the earliest progenitors. This marked difference in the stromal cell activities between PA6 and ST2 could also be distinguished by stromal cell-dependent pre-B cell lines. Among four ST2-dependent pre-B cell lines tested, two grew only on the ST2 layer, which is capable of supporting B lymphopoiesis, while the others grew both on the ST2 and PA6 layers. These results strongly suggest that the process of intra-marrow B cell development is controlled by more than one signal acting on different stages of B cell differentiation.
175 citations
175 citations
TL;DR: A new growth strategy employing chemical vapor deposition is developed to grow monolayer 2D alloys of Re-doped MoSe2 with show composition tunable structural phase variations which provide opportunities to study novel phenomena such as magnetism which broadens the range of their applications.
Abstract: Alloying in 2D results in the development of new, diverse, and versatile systems with prospects in bandgap engineering, catalysis, and energy storage. Tailoring structural phase transitions using alloying is a novel idea with implications in designing all 2D device architecture as the structural phases in 2D materials such as transition metal dichalcogenides are correlated with electronic phases. Here, this study develops a new growth strategy employing chemical vapor deposition to grow monolayer 2D alloys of Re-doped MoSe2 with show composition tunable structural phase variations. The compositions where the phase transition is observed agree well with the theoretical predictions for these 2D systems. It is also shown that in addition to the predicted new electronic phases, these systems also provide opportunities to study novel phenomena such as magnetism which broadens the range of their applications.
175 citations
TL;DR: It is suggested that glutamate can activate CaM kinase II through the ionotropic NMDA receptor, which in turn increases the phosphorylation of microtuble-associated protein 2 and synapsin I.
175 citations
University of Toronto1, University Health Network2, McGill University3, Alberta Children's Hospital4, Asan Medical Center5, University of British Columbia6, The Chinese University of Hong Kong7, University of Alberta8, University of Calgary9, Cincinnati Children's Hospital Medical Center10, University of Colorado Denver11, University of Queensland12, Fudan University13, Seoul National University14, Royal Children's Hospital15, Children's Hospital at Westmead16, University of Debrecen17, Semmelweis University18, University of Szeged19, Université de Montréal20, Virginia Commonwealth University21, Children's National Medical Center22, St. Jude Children's Research Hospital23, Taipei Veterans General Hospital24, Kumamoto University25, Hebrew University of Jerusalem26, University of Utah27, Boston Children's Hospital28, McMaster University29, Children's Hospital of Eastern Ontario30, University of Western Ontario31, Dalhousie University32, Mahidol University33, University of Nottingham34, Children's Memorial Hospital35, University of California, San Francisco36, University of Alabama at Birmingham37, University of Würzburg38, University of Hamburg39, University of Bonn40, Children's Hospital Los Angeles41, University of Southern California42
TL;DR: It is discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and it is suggested that these are promising therapies for this highly lethal ATRT subtype.
175 citations
Authors
Showing all 19645 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Fred H. Gage | 216 | 967 | 185732 |
| George D. Yancopoulos | 158 | 496 | 93955 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Hideo Yagita | 137 | 946 | 70623 |
| Masashi Yanagisawa | 130 | 524 | 83631 |
| Kazuwa Nakao | 128 | 1041 | 70812 |
| Kouji Matsushima | 124 | 590 | 56995 |
| Thomas E. Mallouk | 122 | 549 | 52593 |
| Toshio Hirano | 120 | 401 | 55721 |
| Eisuke Nishida | 112 | 349 | 45918 |
| Hiroaki Shimokawa | 111 | 949 | 48822 |
| Bernd Bukau | 111 | 271 | 38446 |
| Kazuo Tsubota | 105 | 1379 | 48991 |
| Toshio Suda | 104 | 580 | 41069 |