Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Cancer & Population. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Cancer, Population, Gene, Cell culture, Receptor
Papers published on a yearly basis
Papers
More filters
••
TL;DR: A sensitive method has been developed which allows detection of individual T cells that produce either IFN-gamm or IL-5, and should be useful for detection of cytokine secretion at the single cell level.
168 citations
••
Teikyo University1, Mie University2, Nagoya University3, Kumamoto University4, Chiba University5, Washington University in St. Louis6, Indiana University7, University of Buenos Aires8, Georgia Regents University9, University of Hong Kong10, Chang Gung University11, Flinders Medical Centre12, University of Cape Town13, New Generation University College14, Tan Tock Seng Hospital15
TL;DR: In this paper, the authors formulated flowcharts for the management of acute biliary inflammation/infection in accordance with severity grade, and formulated flowchart-based management strategies for acute cholangitis and acute cholecystitis.
Abstract: Diagnostic and therapeutic strategies for acute biliary inflammation/infection (acute cholangitis and acute cholecystitis), according to severity grade, have not yet been established in the world. Therefore we formulated flowcharts for the management of acute biliary inflammation/infection in accordance with severity grade. For mild (grade I) acute cholangitis, medical treatment may be sufficient/appropriate. For moderate (grade II) acute cholangitis, early biliary drainage should be performed. For severe (grade III) acute cholangitis, appropriate organ support such as ventilatory/circulatory management is required. After hemodynamic stabilization is achieved, urgent endoscopic or percutaneous transhepatic biliary drainage should be performed. For patients with acute cholangitis of any grade of severity, treatment for the underlying etiology, including endoscopic, percutaneous, or surgical treatment should be performed after the patient’s general condition has improved. For patients with mild (grade I) cholecystitis, early laparoscopic cholecystectomy is the preferred treatment. For patients with moderate (grade II) acute cholecystitis, early laparoscopic or open cholecystectomy is preferred. In patients with extensive local inflammation, elective cholecystectomy is recommended after initial management with percutaneous gallbladder drainage and/or cholecystostomy. For the patient with severe (grade III) acute cholecystitis, multiorgan support is a critical part of management. Biliary peritonitis due to perforation of the gallbladder is an indication for urgent cholecystectomy and/or drainage. Delayed elective cholecystectomy may be performed after initial treatment with gallbladder drainage and improvement of the patient’s general medical condition.
168 citations
••
TL;DR: Performances of crosslinked poly(allylamine) resin (PAA) as arsenate (As(V)) adsorbent were studied using a column packed with PAA in hydrochloride form, revealing that PAA slightly preferred phosphate to As(V).
168 citations
••
TL;DR: In this article, the authors analyzed several combinations of explosively welded alloys and concluded that the heating rate at the interfaces was of the order of 10 9 K/s, while the cooling rate achieved 10 7 K/S. The formation of different types of metastable phases is discussed with respect to the compositions of the welded materials.
168 citations
••
TL;DR: Increased Ang II activity mediated via the type 1 receptor may be important in the pathogenesis of early cardiovascular inflammatory changes in this model and endothelium-derived NO may decrease MCP-1 production and oxidative stress-sensitive signals by suppressing localized activity of Ang II.
Abstract: Background—The chronic inhibition of NO synthesis by Nω-nitro-l-arginine methyl ester (L-NAME) upregulates the cardiovascular tissue angiotensin II (Ang II)–generating system and induces cardiovascular inflammatory changes in rats. Methods and Results—We used a rat model to investigate the role of local Ang II activity in the pathogenesis of such inflammatory changes. Marked increases in monocyte infiltration into coronary vessels and myocardial interstitial areas, monocyte chemoattractant protein-1 (MCP-1) expression, and nuclear factor-κB (NF-κB, an important redox-sensitive transcriptional factor that induces MCP-1) activity were observed on day 3 of L-NAME administration. Along with these changes, vascular superoxide anion production was also increased. Treatment with an Ang II type 1 receptor antagonist or with a thiol-containing antioxidant, N-acetylcysteine, prevented all of these changes. Conclusions—Increased Ang II activity mediated via the type 1 receptor may thus be important in the pathogenes...
168 citations
Authors
Showing all 19645 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fred H. Gage | 216 | 967 | 185732 |
George D. Yancopoulos | 158 | 496 | 93955 |
Kenji Kangawa | 153 | 1117 | 110059 |
Tasuku Honjo | 141 | 712 | 88428 |
Hideo Yagita | 137 | 946 | 70623 |
Masashi Yanagisawa | 130 | 524 | 83631 |
Kazuwa Nakao | 128 | 1041 | 70812 |
Kouji Matsushima | 124 | 590 | 56995 |
Thomas E. Mallouk | 122 | 549 | 52593 |
Toshio Hirano | 120 | 401 | 55721 |
Eisuke Nishida | 112 | 349 | 45918 |
Hiroaki Shimokawa | 111 | 949 | 48822 |
Bernd Bukau | 111 | 271 | 38446 |
Kazuo Tsubota | 105 | 1379 | 48991 |
Toshio Suda | 104 | 580 | 41069 |