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Institution

Kumamoto University

EducationKumamoto, Kumamoto, Japan
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.


Papers
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Journal ArticleDOI
TL;DR: It is demonstrated that the vascular network could administer biological substances to the interior of the spheroid, and the perfusable vasculature model opens up new possibilities for a long-term tissue culture in vitro.
Abstract: Creating vascular networks in tissues is crucial for tissue engineering Although recent studies have demonstrated the formation of vessel-like structures in a tissue model, long-term culture is still challenging due to the lack of active perfusion in vascular networks Here, we present a method to create a three-dimensional cellular spheroid with a perfusable vascular network in a microfluidic device By the definition of the cellular interaction between human lung fibroblasts (hLFs) in a spheroid and human umbilical vein endothelial cells (HUVECs) in microchannels, angiogenic sprouts were induced from microchannels toward the spheroid; the sprouts reached the vessel-like structures in a spheroid to form a continuous lumen We demonstrated that the vascular network could administer biological substances to the interior of the spheroid As cell density in the spheroid is similar to that of a tissue, the perfusable vasculature model opens up new possibilities for a long-term tissue culture in vitro

153 citations

Journal ArticleDOI
TL;DR: The minimum ADC at pretreatment MR imaging is a useful clinical prognostic biomarker for survival in patients with malignant supratentorial astrocytoma.
Abstract: Purpose: To retrospectively evaluate whether the minimum apparent diffusion coefficient (ADC) of the tumor seen on pretreatment magnetic resonance (MR) images is of prognostic value in patients with malignant supratentorial astrocytoma. Materials and Methods: The study was approved by the institutional review board; the requirement for informed patient consent was waived. Between June 1996 and November 2003, 79 patients (44 male, 35 female; age range, 16–76 years) with malignant supratentorial astrocytoma underwent pretreatment MR imaging. Patient age, symptom duration, neurologic function, mental status, Karnofsky performance scale (KPS) score, extent of surgery, histopathologic diagnosis, tumor component enhancement, and minimum ADC were assessed at factor analysis of survival. Radiation Therapy Oncology Group–recursive partitioning analysis (RTOG-RPA) criteria were used to validate the prognostic value of the minimum ADC. Kaplan-Meier survival curves, the log-rank test, and the multivariate Cox proport...

153 citations

Journal ArticleDOI
TL;DR: This paper showed lineage-specific gene-body DNA methylation recruits H3K9 methyltransferase SETDB1, which methylates H 3K9 immediately downstream of transcription start sites marked with h3K4me3 to establish the bivalent domain.

153 citations

Journal ArticleDOI
18 Apr 2011-ACS Nano
TL;DR: A general substrate-mediated, soft solution methodology for the preparation of extended π-conjugated polymeric nanoarchitectures in low-dimensions based on thermodynamic control over equilibrium polymerization at the solid-liquid interface is demonstrated.
Abstract: The pursuit of methods for design and preparation of robust nanoarchitectonic systems with integrated functionality through bottom-up methodologies remains a driving force in molecular nanotechnology. Through the use of π-conjugated covalent bonds, we demonstrate a general substrate-mediated, soft solution methodology for the preparation of extended π-conjugated polymeric nanoarchitectures in low-dimensions. Based on thermodynamic control over equilibrium polymerization at the solid–liquid interface whereby aromatic building blocks spontaneously and selectively link, close-packed arrays composed of one-dimensional (1-D) aromatic polymers and two-dimensional (2-D) macromolecular frameworks have been prepared and characterized by in situ scanning tunneling microscopy. This methodology eliminates the necessity for severe conditions and sophisticated equipment common to most current fabrication techniques and imparts almost infinite possibilities for the preparation of robust materials with designer molecular...

153 citations

Journal ArticleDOI
TL;DR: Investigating the histopathologic bases of different enhancement patterns on dynamic contrast material-enhanced magnetic resonance (MR) images of cervical cancer found areas of increased contrast enhancement are mainly composed of abundant cancer cell fascicles, whereas poorly perfused areas are composed of fibrous tissue with scattered cancer cells.
Abstract: PURPOSE: To investigate the histopathologic bases of different enhancement patterns on dynamic contrast material–enhanced magnetic resonance (MR) images of cervical cancer and to assess their importance in predicting the outcome of patients after radiation therapy. MATERIALS AND METHODS: Dynamic enhanced MR imaging and pharmacokinetic analyses were performed in 26 patients with cervical cancer who subsequently underwent hysterectomy and in 36 patients with cervical cancer who received radiation therapy. Histopathologic findings and clinical outcomes were correlated with results of dynamic MR imaging and pharmacokinetic analysis. RESULTS: On dynamic MR images of the surgical patients, areas with intense homogenous enhancement showed increased permeability (k = 27.4 × 10−3) compared with areas with poor enhancement (k = 19.0 × 10−3). Well-enhanced areas were predominantly composed of cancer cell fascicles, whereas poorly enhanced areas were composed of fibrous tissue with scattered cancer cells. Radiation t...

153 citations


Authors

Showing all 19645 results

NameH-indexPapersCitations
Fred H. Gage216967185732
George D. Yancopoulos15849693955
Kenji Kangawa1531117110059
Tasuku Honjo14171288428
Hideo Yagita13794670623
Masashi Yanagisawa13052483631
Kazuwa Nakao128104170812
Kouji Matsushima12459056995
Thomas E. Mallouk12254952593
Toshio Hirano12040155721
Eisuke Nishida11234945918
Hiroaki Shimokawa11194948822
Bernd Bukau11127138446
Kazuo Tsubota105137948991
Toshio Suda10458041069
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
202297
20211,701
20201,654
20191,511
20181,330