Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Population, Cancer, Cell culture, Stem cell, Cellular differentiation
Papers published on a yearly basis
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TL;DR: The concept of diabetes mellitus as mentioned in this paper is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action.
Abstract: Concept of Diabetes Mellitus:
Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involves both genetic and environmental factors. The long‐term persistence of metabolic disorders can cause susceptibility to specific complications and also foster arteriosclerosis. Diabetes mellitus is associated with a broad range of clinical presentations, from being asymptomatic to ketoacidosis or coma, depending on the degree of metabolic disorder.
1,446 citations
TL;DR: A neodymium oxide with relative 143Nd/144Nd ratio 1.000503±1(1 σm) to LaJolla Nd was prepared as a new isotopic reference as mentioned in this paper.
1,431 citations
TL;DR: Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions.
1,372 citations
TL;DR: Examination of the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure concludes that BNP is secreted mainly from the left ventricle in normal adult humans as well as in Patients with left ventricular dysfunction.
Abstract: BACKGROUNDB-type or brain natriuretic peptide (BNP) is a novel natriuretic peptide secreted from the heart that forms a peptide family with A-type or atrial natriuretic peptide (ANP), and its plasma level has been shown to be increased in patients with congestive heart failure. This study was designed to examine the sources and mechanisms of the secretion of BNP in comparison with those of ANP in control subjects and in patients with heart failure.METHODS AND RESULTSWe measured the plasma levels of BNP as well as ANP in 16 patients with dilated cardiomyopathy (11 men and 5 women; mean age, 59 years) and 18 control subjects (9 men and 9 women; mean age, 54 years) by sampling blood from the femoral vein, the aortic root, the anterior interventricular vein (AIV), and the coronary sinus using the newly developed immunoradiometric assay systems. In the control subjects, there was no significant difference in the plasma ANP level between the aortic root and the AIV (24.0 +/- 5.2 pg/mL versus 32.2 +/- 17.0 pg/mL...
1,348 citations
TL;DR: It is found that Bim is essential for ER stress-induced apoptosis in a diverse range of cell types both in culture and within the whole animal.
1,335 citations
Authors
Showing all 19645 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Fred H. Gage | 216 | 967 | 185732 |
| George D. Yancopoulos | 158 | 496 | 93955 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Hideo Yagita | 137 | 946 | 70623 |
| Masashi Yanagisawa | 130 | 524 | 83631 |
| Kazuwa Nakao | 128 | 1041 | 70812 |
| Kouji Matsushima | 124 | 590 | 56995 |
| Thomas E. Mallouk | 122 | 549 | 52593 |
| Toshio Hirano | 120 | 401 | 55721 |
| Eisuke Nishida | 112 | 349 | 45918 |
| Hiroaki Shimokawa | 111 | 949 | 48822 |
| Bernd Bukau | 111 | 271 | 38446 |
| Kazuo Tsubota | 105 | 1379 | 48991 |
| Toshio Suda | 104 | 580 | 41069 |