Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Cancer & Population. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Cancer, Population, Gene, Cell culture, Receptor
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors show that naturally occurring S mutations can reduce or enhance cell entry via ACE2 and TMPRSS2, and conclude that the D614G mutation increases cell entry by acquiring higher affinity to ACE2 while maintaining neutralization susceptibility.
Abstract: The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the ACE2 receptor and is cleaved by TMPRSS2. However, whether S mutations affect SARS-CoV-2 cell entry remains unknown. Here, we show that naturally occurring S mutations can reduce or enhance cell entry via ACE2 and TMPRSS2. A SARS-CoV-2 S-pseudotyped lentivirus exhibits substantially lower entry than that of SARS-CoV S. Among S variants, the D614G mutant shows the highest cell entry, as supported by structural and binding analyses. Nevertheless, the D614G mutation does not affect neutralization by antisera against prototypic viruses. Taken together, we conclude that the D614G mutation increases cell entry by acquiring higher affinity to ACE2 while maintaining neutralization susceptibility. Based on these findings, further worldwide surveillance is required to understand SARS-CoV-2 transmissibility among humans.
329 citations
TL;DR: This paper is a review of the recent progress on gas sensors using graphene oxide (GO), and several applications of GO based sensors are summarized for detection of water vapor, NO2,H2, NH3, H2S, and organic vapors.
328 citations
TL;DR: The molecular weight-dependence of tumour capture of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers was studied in vivo using subcutaneous Sarcoma 180 or B16F10 melanoma models and the ratio (accumulation index, AI) of the AUC in tumour to A UC in skeletal muscle (a typical normal tissue) increasing from six to 12 with increasing copolymer molecular weight.
327 citations
TL;DR: It is demonstrated that the linear sequence SVVYGLR directly binds to α9 β1 and is responsible for α9β1-mediated cell adhesion to the NH2-terminal fragment of osteopontin.
324 citations
TL;DR: A clinical evaluation of arterial infusion of high-molecular-weight antitumor agent SMANCS dissolved in lipid lymphographic agent (thiodol) in 44 patients with mostly unresectable hepatoma demonstrated significant merits both therapeutically and diagnostically.
324 citations
Authors
Showing all 19645 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Fred H. Gage | 216 | 967 | 185732 |
| George D. Yancopoulos | 158 | 496 | 93955 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Hideo Yagita | 137 | 946 | 70623 |
| Masashi Yanagisawa | 130 | 524 | 83631 |
| Kazuwa Nakao | 128 | 1041 | 70812 |
| Kouji Matsushima | 124 | 590 | 56995 |
| Thomas E. Mallouk | 122 | 549 | 52593 |
| Toshio Hirano | 120 | 401 | 55721 |
| Eisuke Nishida | 112 | 349 | 45918 |
| Hiroaki Shimokawa | 111 | 949 | 48822 |
| Bernd Bukau | 111 | 271 | 38446 |
| Kazuo Tsubota | 105 | 1379 | 48991 |
| Toshio Suda | 104 | 580 | 41069 |