Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Population, Cancer, Cell culture, Stem cell, Cellular differentiation
Papers published on a yearly basis
Papers
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TL;DR: An (hk0)-oriented p-type CaFe2O4 (E(g): 1.9 eV) photocathode was prepared, and hydrogen and oxygen gases were produced from a photocell short-circuited by connecting the CaFe 2O4 and n-type TiO2 electrodes under illumination without applying an external voltage.
Abstract: An (hk0)-oriented p-type CaFe2O4 (Eg: 1.9 eV) photocathode was prepared, and hydrogen and oxygen gases were produced from a photocell short-circuited by connecting the CaFe2O4 and n-type TiO2 electrodes under illumination without applying an external voltage. The open-circuited voltage was 0.97 V and the short-circuit current was about 200 μA/cm2, and the amount of evaluated hydrogen and oxygen gases after 2 days of reaction were about 70 and 4 μmol, respectively.
274 citations
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TL;DR: The prompt and correct recognition of MG following treatment with immune checkpoint inhibitors in patients with cancer is important and postintervention status showed that pharmacologic remission or minimal manifestations were obtained in 4 patients; however, 2 patients died.
Abstract: Objective: To report the clinical features of myasthenia gravis (MG) induced by treatment with immune checkpoint inhibitors using 2-year safety databases based on postmarketing surveys in Japan. Methods: We studied 10,277 patients with cancer who had received monotherapy with either nivolumab or ipilimumab between September 2014 and August 2016. As the control group, 105 patients with idiopathic MG were used. Results: There were 12 MG cases (0.12%) among 9,869 patients with cancer who had been treated with nivolumab, but none among 408 patients treated with ipilimumab. These 12 patients included 6 men and 6 women with a mean age of 73.5 ± 6.3 years. MG onset occurred in the early phase after nivolumab treatment and rapidly deteriorated. Nivolumab-related MG (nivoMG) included 4 patients with mild involvement and 8 patients with severe involvement. Bulbar symptoms and myasthenic crisis were observed more frequently in nivoMG than idiopathic MG. Ten patients were positive for anti–acetylcholine receptor antibodies. Serum creatine kinase levels were markedly elevated to an average level of 4,799 IU/L. Among the 12 patients with nivoMG, 4 had myositis and 3 had myocarditis, with 1 of these patients having both. Immunosuppressive therapy was effective. Postintervention status showed that pharmacologic remission or minimal manifestations were obtained in 4 patients; however, 2 patients died. Immune-related adverse events triggered by nivolumab impaired the patients9 daily living activity. Conclusions: The prompt and correct recognition of MG following treatment with immune checkpoint inhibitors in patients with cancer is important.
274 citations
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TL;DR: The main contribution of this work is the utilization of the two-diode model to represent the PV cell, requiring only four parameters and known to have better accuracy at low irradiance level, allowing for more accurate prediction of PV system performance during partial shading condition.
273 citations
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TL;DR: Fish and hair samples as the best indicators of human methylmercury contamination were investigated in the main cities and villages along the Tapajós river basin and critical fish, areas, and more exposed human groups are identified.
272 citations
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TL;DR: Data indicate that the PI3K pathway is critical for insulin's actions in the liver in vivo, and that differential regulation by Akt and PKClambda/xi differentially defines specific actions of insulin andPI3K on hepatic glucose and lipid metabolism.
272 citations
Authors
Showing all 19645 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fred H. Gage | 216 | 967 | 185732 |
George D. Yancopoulos | 158 | 496 | 93955 |
Kenji Kangawa | 153 | 1117 | 110059 |
Tasuku Honjo | 141 | 712 | 88428 |
Hideo Yagita | 137 | 946 | 70623 |
Masashi Yanagisawa | 130 | 524 | 83631 |
Kazuwa Nakao | 128 | 1041 | 70812 |
Kouji Matsushima | 124 | 590 | 56995 |
Thomas E. Mallouk | 122 | 549 | 52593 |
Toshio Hirano | 120 | 401 | 55721 |
Eisuke Nishida | 112 | 349 | 45918 |
Hiroaki Shimokawa | 111 | 949 | 48822 |
Bernd Bukau | 111 | 271 | 38446 |
Kazuo Tsubota | 105 | 1379 | 48991 |
Toshio Suda | 104 | 580 | 41069 |