Kuvempu University

About: Kuvempu University is a(n) education organization based out in Shimoga, India. It is known for research contribution in the topic(s): Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publication(s) receiving 39755 citation(s). The organization is also known as: KU.

Human Protein Reference Database—2009 update

Abstract: Human Protein Reference Database (HPRD--http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added a number of new features in HPRD. These include PhosphoMotif Finder, which allows users to find the presence of over 320 experimentally verified phosphorylation motifs in proteins of interest. Another new feature is a protein distributed annotation system--Human Proteinpedia (http://www.humanproteinpedia.org/)--through which laboratories can submit their data, which is mapped onto protein entries in HPRD. Over 75 laboratories involved in proteomics research have already participated in this effort by submitting data for over 15,000 human proteins. The submitted data includes mass spectrometry and protein microarray-derived data, among other data types. Finally, HPRD is also linked to a compendium of human signaling pathways developed by our group, NetPath (http://www.netpath.org/), which currently contains annotations for several cancer and immune signaling pathways. Since the last update, more than 5500 new protein sequences have been added, making HPRD a comprehensive resource for studying the human proteome.

NetPath: a public resource of curated signal transduction pathways

Abstract: We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

Electrocatalytic Properties and Sensor Applications of Fullerenes and Carbon Nanotubes

Abstract: The electrochemical behavior of fullerene and fullerene derivatives are reviewed with special reference to their catalytic and sensor applications. Recent work on carbon nanotubes, used as catalyst supports in heterogeneous catalysis and sensor development is also presented. An overview of recent progress in the area of fullerene electrochemistry is included. Several cases of electrocatalytic dehalogenation of alkyl halides, assisted by the electrode charge transfer to fullerenes, are discussed. Research work on the electrocatalysis of biomolecules, such as hemin, cytochrome c, DNA, coenzymes, glucose, ascorbic acid, dopamine, etc. have also been considered. Based on the studies of the interaction of fullerenes, fullerene derivatives, and carbon nanotubes with other molecules and biomolecules in particular, the possibilities for the preparation of electrochemical sensors and their application in electroanalytical chemistry are highlighted.

Kinetics and thermodynamics studies on the adsorption of Zn(II), Cd(II) and Hg(II) from aqueous solution using zinc oxide nanoparticles

Abstract: The aim of this study is to investigate the utilization of the zinc oxide nanoparticles (ZnO) as an adsorbent for the removal of Zn(II), Cd(II) and Hg(II) ions from aqueous solution. Adsorption properties of ZnO towards Zn(II), Cd(II) and Hg(II) ions were systematically investigated, including pH effect, adsorption equilibrium, adsorption kinetics and temperature. The adsorption isotherms were well described by Langmuir isotherm model with correlating constant (R 2 ) higher than 0.99. The maximum adsorption capacity was determined at 303 K and were found to be 357, 387 and 714 mg/g for Zn(II), Cd(II) and Hg(II) ions respectively. The adsorption kinetics data were well fitted by the pseudo-second-order rate model with high regression coefficients. The adsorption capacity was decreased with the increase of temperature, and thermodynamic calculations suggested that the adsorption of Zn(II), Cd(II) and Hg(II) ions onto ZnO nanoparticles is an exothermic process.

An evaluation of human protein-protein interaction data in the public domain

Abstract: Protein-protein interaction (PPI) databases have become a major resource for investigating biological networks and pathways in cells. A number of publicly available repositories for human PPIs are currently available. Each of these databases has their own unique features with a large variation in the type and depth of their annotations. We analyzed the major publicly available primary databases that contain literature curated PPI information for human proteins. This included BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome databases. The number of binary non-redundant human PPIs ranged from 101 in PDZBase and 346 in MIPS to 11,367 in MINT and 36,617 in HPRD. The number of genes annotated with at least one interactor was 9,427 in HPRD, 4,975 in MINT, 4,614 in IntAct, 3,887 in BIND and <1,000 in the remaining databases. The number of literature citations for the PPIs included in the databases was 43,634 in HPRD, 11,480 in MINT, 10,331 in IntAct, 8,020 in BIND and <2,100 in the remaining databases. Given the importance of PPIs, we suggest that submission of PPIs to repositories be made mandatory by scientific journals at the time of manuscript submission as this will minimize annotation errors, promote standardization and help keep the information up to date. We hope that our analysis will help guide biomedical scientists in selecting the most appropriate database for their needs especially in light of the dramatic differences in their content.