Kuvempu University

About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.

Electrochemical study of hydrochlorothiazide on electrochemically pre-treated pencil graphite electrode as a sensor

Abstract: An electrochemical anodic behavior of hydrochlorothiazide (HCTZ) was studied by using electrochemically pretreated pencil graphite electrode (EPPGE) using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV). Two anodic peaks were observed at peak potential 842 mV and 1091 mV on EPPGE at phosphate buffer (pH 7.0). Electrooxidation process of HCTZ shows diffusion-controlled process on EPPGE. DPV and SWV show a good linearity in the concentration range 4 μM to 140 μM and 1 μM to 20 μM, respectively. The limits of detection were found to be 3.25 μM L− 1 and 0.421 μM L− 1, respectively. Electrochemical impedance spectra (EIS) gave the charge transfer resistance at EPPGE (32.3 kΩ) and PGE (867 kΩ), which shows an increase in the electron transfer rate at EPPGE than that of PGE. Surface area, sensitivity and electron transfer kinetic parameters were studied. Electrochemical pretreatment is a simpler method compared to other modifications for the electrodes and this method could be applied for the sensitive determination of HCTZ present in pharmaceutical formulations and urine samples.

Antibacterial and molecular docking studies of entagenic acid, a bioactive principle from seed kernel of Entada pursaetha DC

Abstract: In vitro antibacterial activity of a phytoconstituent, entagenic acid isolated from the seed kernel of Entada pursaetha DC was screened against both gram negative and gram positive bacteria. The entagenic acid showed the high antibacterial activity against B. cereus and B. subtilis with minimal inhibitory concentration of 200 μg ml−1 and possesses better glucosamine-6-phosphate synthase inhibition in molecular docking studies with minimum docking energy −9.22 kJ mol−1, binding energy −9.28 kJ mol−1 and inhibition constant 1.57e−007. The inhibition constant of streptomycin was 3.86e−005.