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Institution

Kuvempu University

EducationShimoga, India
About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.


Papers
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Journal ArticleDOI
01 Jan 2020
TL;DR: In this article, the Poly (Reactive Blue) modified carbon paste electrode (MCPE) exhibited good stable and sensitive current responses towards the determination of dopamine (DA) in phosphate buffer solution (PBS pH 7.4).
Abstract: The Poly (Reactive Blue) modified carbon paste electrode (MCPE) exhibited good stable and sensitive current responses towards the determination of dopamine (DA) in phosphate buffer solution (PBS pH 7.4). The various parameters like the effect of scan rate, pH and concentration of DA studied. The electrode process was found to be adsorption-controlled and the limit of detection (LOD) of DA obtained to be 4.64 μM. The simultaneous determination of DA in the presence of Ascorbic acid (AA) and Uric acid (UA) was investigated by using cyclic voltammetry (CV). The application of the developed electrode was demonstrated by detecting DA in injection sample with satisfactory recoveries. The sensor was stable, sensitive, selective and reproducible. Highlights •Poly (Reactive blue) sensor developed for the detection of dopamine.•Determination of DA in presence of UA and AA.•Low cost, good selectivity and high sensitive.

24 citations

Journal ArticleDOI
TL;DR: In this article, 4.4-Nitrophthalic acid was found to be an effective catalyst for the imino Diels-Alder reaction of N-benzylideneanilines with 3,4-dihydro-2H-pyran and 2,3-dishydrofuran to afford pyrano-and furanoquinolines in good yields.
Abstract: 4-Nitrophthalic acid was found to be an effective catalyst for the imino Diels-Alder reaction of N-benzylideneanilines with 3,4-dihydro-2H-pyran and 2,3-dihydrofuran to afford pyrano- and furanoquinolines in good yields. It was also found that aryl amines react smoothly with 3,4-dihydro-2H-pyran and 2,3-dihydrofuran under the same condition to afford the corresponding pyrano- and furanoquinolines in high yields. This catalyst is inexpensive, easily available, water soluble, and stable to aqueous reaction conditions.

23 citations

Journal ArticleDOI
TL;DR: In this paper, the authors have synthesized four heterocyclic azo dyes by conventional diazo-coupling reaction between aniline derivatives with 5-methyl-2-(6methyl-1,3-benzothiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one at lower temperatures and characterized by physico-chemical techniques.

23 citations

Journal ArticleDOI
TL;DR: The findings suggest that RRBP1 is an interesting molecule that can be further studied for its potential to serve as a breast cancer biomarker and demonstrates how the integration of biological data from available resources in conjunction with systematic evaluation approaches can be successfully applied to clinical proteomics.
Abstract: The molecular events that lead to malignant transformation and subsequent metastasis of breast carcinoma include alterations in the cells at genome, transcriptome and proteome levels. In this study, we used publicly available gene expression databases to identify those candidate genes which are upregulated at the mRNA level in breast cancers but have not been systematically validated at the protein level. Based on an extensive literature search, we identified ribosome binding protein 1 (RRBP1) as a candidate that is upregulated at the mRNA level in five different studies but its protein expression had not been investigated. Immunohistochemical labeling of breast cancer tissue microarrays was carried out to determine the expression of RRBP1 in a large panel of breast cancers. We found that RRBP1 was overexpressed in 84% (177/219) of breast carcinoma cases tested. The subcellular localization of RRBP1 was mainly observed to be in the cytoplasm with intense staining in the perinuclear region. Our findings suggest that RRBP1 is an interesting molecule that can be further studied for its potential to serve as a breast cancer biomarker. This study also demonstrates how the integration of biological data from available resources in conjunction with systematic evaluation approaches can be successfully applied to clinical proteomics.

23 citations

Journal ArticleDOI
18 Nov 2017
TL;DR: Six curcumin analogues are revealed as promising ALK5 inhibitors with significant binding energy and H-bonding interaction, which is an important hallmark of malignant cancer disease.
Abstract: During metastasis, cancer cells transcend from primary site to normal cells area upon attaining epithelial to mesenchymal transition (EMT) causing malignant cancer disease. Increased expression of TGF-β and its receptor ALK5 is an important hallmark of malignant cancer. In the present study, efficacy of curcumin and its analogues as inhibitors of ALK5 (TGFβR-I) receptor was evaluated using in silico approaches. A total of 142 curcumin analogues and curcumin were retrieved from peer reviewed literature and constructed a combinatorial library. Further their drug-likeness was assessed using Molinspiration, cheminformatics and preADMET online servers. The interaction of 142 curcumin analogues and curcumin with ALK5 receptor was studied using Autodock Vina. This study revealed six curcumin analogues as promising ALK5 inhibitors with significant binding energy and H-bonding interaction.

23 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20238
202224
2021214
2020189
2019139
2018135