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Institution

Kuvempu University

EducationShimoga, India
About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.


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Journal ArticleDOI
TL;DR: In this article, a cyclic voltammetric method was used to study the anodic peak current of a methionine modified carbon paste electrode and a bare carbon paste (BSP) electrode for the electro-oxidation of ascorbic acid (AA).
Abstract: The electrocatalytic behavior of a methionine modified carbon paste electrode and bare carbon paste electrode for the electro-oxidation of ascorbic acid (AA) was studied by using a cyclic voltammetric method. The obtained results showed good enhancement in the anodic peak current in the case of the modified electrode compared to the bare electrode. The anodic peak current showed a linear relationship with increase in the concentration of AA, and a linear calibration curve is obtained in the range of 5.0 × 10−6 to 12 × 10−5 mol L−1 concentration of AA. The applicability of the proposed method was adapted for the determination of the concentration of AA present in real samples and the results were found to be satisfactory.

23 citations

Journal ArticleDOI
TL;DR: To identify potential biomarkers of epileptogenicity, the mRNA profiles of surgically resected tissue from seizure zones with non-seizure zones from cases of intractable MTLE were compared and 413 genes that exhibited ≥2-fold change were identified that were statistically significant across these two groups.
Abstract: Epilepsy is one of the most prevalent neurological disorders affecting ~1% of the population. Medial temporal lobe epilepsy (MTLE) is the most frequent type of epilepsy observed in adults who do not respond to pharmacological treatment. The reason for intractability in these patients has not been systematically studied. Further, no markers are available that can predict the subset of patients who will not respond to pharmacotherapy. To identify potential biomarkers of epileptogenicity, we compared the mRNA profiles of surgically resected tissue from seizure zones with non-seizure zones from cases of intractable MTLE. We identified 413 genes that exhibited ≥2-fold change that were statistically significant across these two groups. Several of these differentially expressed genes have not been previously described in the context of MTLE including claudin 11 (CLDN11) and bone morphogenetic protein receptor, type IB (BMPR1B). In addition, we found significant downregulation of a subset of gamma-aminobutyric acid (GABA) associated genes. We also identified molecules such as BACH2 and ADAMTS15, which are already known to be associated with epilepsy. We validated one upregulated molecule, serine/threonine kinase 31 (STK31) and one downregulated molecule, SMARCA4, by immunohistochemical labeling of tissue sections. These molecules need to be further confirmed in large-scale studies to determine their potential use as diagnostic as well as prognostic markers in intractable MTLE.

23 citations

Journal ArticleDOI
TL;DR: The photo induced cleavage studies shows that theCu(II) complexes possess photonuclease property against pUC19 DNA under UV-Visible irradiation via a mechanistic pathway involving formation of singlet oxygen as the reactive species.

22 citations

Journal ArticleDOI
TL;DR: These compounds may be considered as good inhibitors of the E. coli MurB enzyme (PDB code: 2MBR) and showed a minimum binding energy and good affinity towards the active pocket comparable with the standard drug Ciproflaxin.
Abstract: The synthesis of a new series of 3-{5-methyl-1-[2-methyl-3-(trifluoromethyl) phenyl/substituted phenyl]-1H-1,2,3-triazol-4-yl}-1-(aryl)-1H-pyrazole-4-carbaldehyde compounds (5a–n) was carried out via a Vilsmeier–Haack formylation of 4-{(1E)-1-[2-(aryl) hydrazinylidene]ethyl}-5-methyl-1-[2-methyl-3-(trifluoromethyl)phenyl/substituted phenyl]-1H-1,2,3-triazole (4a–n) with a phosphorous oxychloride and DMF mixture. The newly synthesized compounds were characterized using IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. The newly synthesized compounds were screened for their in vitro anti-bacterial, anti-fungal and anti-oxidant activities. Some of the synthesized compounds displayed a broad spectrum of antimicrobial activities and moderate to good anti-oxidant activities. The anti-bacterial results were further supported by in silico molecular docking studies of these compounds for the inhibition of E. coli MurB enzyme (PDB code: 2MBR) and showed a minimum binding energy and good affinity towards the active pocket comparable with the standard drug Ciproflaxin. Thus, they may be considered as good inhibitors of the E. coli MurB enzyme (PDB code: 2MBR).

22 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20238
202224
2021214
2020189
2019139
2018135