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Institution

Kuvempu University

EducationShimoga, India
About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.


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Journal ArticleDOI
TL;DR: Results showed that 8-methyl-4-(3 diethylaminopropylamino) pyrimido [4′,5′:4,5] selenolo(2,3-b)quinoline (MDPSQ) induces cytotoxicity in a time- and concentration-dependent manner on leukemic cell lines.
Abstract: DNA intercalating molecules are promising chemotherapeutic agents. In the present study, a novel DNA intercalating compound of pyrimido[4',5':4,5]selenolo(2,3-b)quinoline series having 8-methyl-4-(3 diethylaminopropylamino) side chain is studied for its chemotherapeutic properties. Our results showed that 8-methyl-4-(3 diethylaminopropylamino) pyrimido [4',5':4,5] selenolo(2,3-b)quinoline (MDPSQ) induces cytotoxicity in a time- and concentration-dependent manner on leukemic cell lines. Both cell cycle analysis and tritiated thymidine assays revealed that MDPSQ affects DNA replication. Treatment with MDPSQ resulted in both elevated levels of DNA strand breaks and repair proteins, further indicating its cytotoxic effects. Besides, Annexin V/PI staining revealed that MDPSQ induces cell death by triggering necrosis rather than apoptosis.

22 citations

Journal ArticleDOI
01 May 2020
TL;DR: In this article, the impact of europium (Eu3+) ion doping has been outlined in improving the structure and optical properties of macroporous honeycomb-like zinc oxide (ZnO) nanoparticles, produced by the gel-combustion technique by changing the quantity of dopant.
Abstract: The impact of europium (Eu3+) ion doping has been outlined in improving the structure and optical properties of macroporous honeycomb-like zinc oxide (ZnO) nanoparticles, produced by the gel-combustion technique by changing the quantity of dopant. The X-ray diffraction (XRD) research verified that the hexagonal wurtzite structure of ZnO was not disturbed by Eu3+ substitution. Scherrer method, Scherrer plots (SP), Williamson-Hall (W–H) plots and Size-Strain plots (SSP) were used to estimate the crystallite size. Decreased crystallite size in ZnO:Eu3+ was noticed along with lower angle shift of XRD peaks and increased lattice parameters such as unit cell volume that can be described as replacement result of Eu3+ at Zn sites. Fourier transform infrared (FTIR) spectroscopy analysis confirmed the Eu3+ dopant by moving the peak from 474 cm−1 to 525 cm−1. Field-emission scanning electron microscopy (FESEM) pictures verified macroporous honeycomb-like structures. UV–Visible (UV–Vis) absorption spectroscopic studies show that the ability of ZnO:Eu3+ nanoparticles concerning the absorption of visible light increased upon Eu3+ doping with a red shift compared to ZnO nanoparticles. Photoluminescence (PL) emission spectra of Eu3+ doped ZnO nanoparticles exhibited five intense band emissions at 579, 591, 617, 652, and 706 nm ascribed to 5D0 → 7F0, 5D0 → 7F1, 5D0 → 7F2, 5D0 → 7F3, and 5D0 → 7F4 transitions of Eu3+ ions when excited at 465 nm wavelength, originated from intra-4f transition of Eu3+ ions, respectively. ZnO:Eu3+ nanoparticles intensified with concentration progression and revealed as nanoparticles emitting red under 465 nm excitation.

22 citations

Journal ArticleDOI
TL;DR: Semi-interpenetrating network microspheres of chitosan-(dextran-g-acrylamide) were prepared by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent to confirm the graft copolymer, formation of semi-IPN structure of MPs and molecular distribution of the drug molecules in the polymer matrix.
Abstract: Semi-interpenetrating network microspheres of chitosan-(dextran-g-acrylamide) were prepared by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. Graft copolymerization of dextran with acrylamide (Dx-g-AAm) was carried out by aqueous free-radical polymerization using ceric ammonium nitrate (CAN) as initiator. The grafting efficiency was found to be 92%. Theophylline (TH), antiasthmatic drug, was successfully encapsulated into semi-INP microspheres by varying the ratio of Dx-g-AAm and amount of GA. The laser light scattering technique shows that the particles size increased with increasing amount of graft copolymer and decrease with increasing amount of GA. The % encapsulation efficiency was found to vary between 50 and 78. MPs were characterized by FTIR spectroscopy and differential scanning calorimetry (DSC) techniques to confirm the graft copolymer, formation of semi-IPN structure of MPs and molecular distribution of the drug molecules in the polymer matrix. In vitro release studies of TH from these matrices have been investigated at Ph 1.2 and 7.4 media and the slow release were extended up to 18 h at 37°C. The release rates were fitted to an empirical equation to estimate the diffusion exponent n, which indicated that the release from the MPs follows non-Fickian type.

22 citations

Journal ArticleDOI
TL;DR: It is suggested that perennial grasses harbor diverse fungal communities whose potential could be tapped for producing secondary metabolites and managing plant diseases.
Abstract: Fungal communities associated with roots play an important role in nutrient cycling, supporting plant growth and the biocontrol of plant diseases. Experiments were conducted in 2004-2006 to isolate and characterize, based on their morphological features, rhizosphere and rhizoplane fungi from perennial grasses of the subfamily Panicoideae growing in forests of the Western Ghats in India. Fungal species were isolated on potato dextrose, czapeck dox and water agar, in different locations and seasons. The results obtained on PDA were used for detailed analysis since most fungi occurred in high percentages. While certain grasses harbored diverse fungal species, others supported only a few species. Most fungi were isolated during winter followed by the rainy and summer seasons. The species richness, diversity and evenness of fungal assemblages in the rhizosphere and rhizoplane depended on the grass species and season. Ascomycetes were isolated in large numbers in most grass species. Species of Aspergillus, Chaetomium, Penicillium and Trichoderma occurred frequently. Certain others and non-sporulating fungi were grass species-specific. Most fungal species colonized the middle of the root more than the root tip or root base. Results suggest that perennial grasses harbor diverse fungal communities whose potential could be tapped for producing secondary metabolites and managing plant diseases.

22 citations

Journal ArticleDOI
TL;DR: In this paper, the Triton-X 100 (TX-100) modified carbon paste electrode showed electrocatalytic properties and an enhancement in the peak currents for dopamine.
Abstract: ZnO was synthesized by a mechanochemical method and characterized by powder X-ray diffraction, UV-visible absorption, scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). ZnO/CTAB and ZnO/TX-100 modified carbon paste electrodes were used as electrochemical sensors for dopamine. The Triton-X 100 (TX-100) modified carbon paste electrode shows electrocatalytic properties and an enhancement in the peak currents for dopamine. CTAB modified carbon paste electrodes are less sensitive for the determination of dopamine. The effect of ZnO concentration, scan rate and concentration of dopamine (DA) and ascorbic acid (AA) was varied and a simultaneous determination of DA and AA at the ZnO/TX-100 CPE was carried out.

22 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20238
202224
2021214
2020189
2019139
2018135