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Institution

Kuvempu University

EducationShimoga, India
About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.


Papers
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Journal ArticleDOI
TL;DR: In this article, the Vilsmeier-Haack reaction with POCl3 in DMF yielded (5,7-dichloro-1,3-benzoxazol-2-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde derivatives 6a-e.
Abstract: Condensation of 5,7-dichloro-2-hydrazino-1,3-benzoxazole 3 with different aromatic acetophenones in methanol using catalytic amount of glacial acetic acid afforded the corresponding 1-phenylethanone(5,7-dichloro-1,3-benzoxazol-2-yl)hydrazones 5a–e in good yield. The compounds 5a–e, when subjected to Vilsmeier–Haack reaction with POCl3 in DMF yielded (5,7-dichloro-1,3-benzoxazol-2-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde derivatives 6a–e. The structural assignments of the compounds 6a–e are based on their spectral data and elemental analysis. The obtained compounds were tested for antimicrobial and analgesic activities, and subjected to molecular docking studies with respect to antimicrobial activity. The compound 6b showed pronounced antimicrobial and analgesic activity and exhibited an interesting binding profile with very high receptor affinity.

22 citations

Journal ArticleDOI
TL;DR: 1,2,4‐triazole‐based Schiff base heterocyclic compounds synthesized and evaluated for antioxidant properties by free‐radical scavenging, anti‐hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage showed promising DPPH• radical scavenging activity.
Abstract: A series of 1,2,4-triazole-based Schiff base heterocyclic compounds (5a-f and 8a-i) and phenethylamines (7a-h) were synthesized and evaluated for antioxidant properties by free-radical scavenging, anti-hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage. Compounds 7c, 7d, 7h, 8b, and 8i showed promising DPPH(•) radical scavenging activity with the level of inhibition between 86.8% and 94%. Compounds 8a, 8b, 8d, 8g, and 8i were effective against the oxidative hemolysis of human erythrocytes and lipid peroxidation, in a dose-dependent manner, with IC50 values in the range of 55.7-80.7 and 53.2-81.2 µg/mL, respectively. Compounds 8a and 8b were effective against oxidative damage on erythrocyte ghost membrane proteins, and 8g and 8i were able to protect against DNA oxidative damage.

22 citations

Journal ArticleDOI
TL;DR: In this paper, the synthesis and characterization of metal (II) 1,3,8,10,15,17,22,24 octachlorophthalocyanines (MPOCls) using modified Sandmayer's method was described.

22 citations

Journal ArticleDOI
TL;DR: This study provides tangible evidences that latex sap from L. siceraria with immunopotentiating ability significantly regresses the tumor progression by targeting angiogenesis and inducing cell death.

22 citations

Journal ArticleDOI
TL;DR: In this article, a sensitive and selective electrochemical method using a hydroxy double salt/surfactant film modified carbon paste electrode (HDS/SDS/CPE) was developed for the electrochemical determination of dopamine.

22 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20238
202224
2021214
2020189
2019139
2018135