Kuvempu University

About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.

A Facile Synthesis of Bromo-Substituted Benzofuran Containing Thiazolidinone Nucleus Bridged with Quinoline Derivatives: Potent Analgesic and Antimicrobial Agents

Abstract: Treatment of 5-bromo-2-acetyl benzofuran with hydrazine followed by condensation of the resulting hydrazone with different quinoline derivatives gave the corresponding Schiff bases. Reaction of these Schiff bases with thioacetic acid furnished the target thiazolidinone molecule. Some of the newly synthesized compounds show promising analgesic and antimicrobial activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

A multilectin affinity approach for comparative glycoprotein profiling of rheumatoid arthritis and spondyloarthropathy

Abstract: Background Arthritis refers to inflammation of joints and includes common disorders such as rheumatoid arthritis (RA) and spondyloarthropathies (SpAs). These diseases differ mainly in terms of their clinical manifestations and the underlying pathogenesis. Glycoproteins in synovial fluid might reflect the disease activity status in the joints affected by arthritis; yet they have not been systematically studied previously. Although markers have been described for assisting in the diagnosis of RA, there are currently no known biomarkers for SpA.

Rice GWAS reveals key genomic regions essential for salinity tolerance at reproductive stage

Abstract: Salt tolerance is an important complex trait in rice which helps the plant to survive under salt stress condition. The complexity of salt tolerance is governed by many genes which could be identified efficiently by genome wide association study (GWAS). In the present study, we evaluated 180 diverse rice accessions for salinity tolerance at reproductive stage and successfully genotyped them using simple sequence repeats markers covering all 12 chromosomes. Eleven physiological parameters which include Na+, K+, Ca2+, Mg2+ content in stem and leaves and two important morphological traits grain yield and salt injury score were measured under control and saline conditions at reproductive stage. Population structure analysis revealed four subgroups and admixture level ranged from 0.70 to 57.2%. Association study using mixed linear model controlling both structure and kinship, identified 28 significant marker-trait associations and out of which 19 associations were identified for Na+, K+, Na+/K+ uptake in stem and leaves. The phenotypic variance for these associations ranged from 5.12 to 13.37%. The position of several associated markers was found close to candidate genes like transcription factors, membrane transporters, signal transducers which have previously shown to play active roles of salinity tolerance in rice. The present GWAS was successful in unravelling genomic regions that regulate ionic homoeostasis in rice. Furthermore, the salinity tolerant accessions identified during the screening could become important resource for breeding programs.