Institution
Kuvempu University
Education•Shimoga, India•
About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.
Papers published on a yearly basis
Papers
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TL;DR: Hydxyapatite formation was observed on the surfaces of nanocomposites, indicating that prepared composites are bioactive and provides an analytical method for the assessment of titanium dioxide nanoparticles filled poly(2-hydroxyethylmethacrylate) polymer nanocomPOSites for biomedical applications.
17 citations
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TL;DR: In this article, the effect of colchicine (CC) on mild steel (MS) corrosion in 1-M HCl solution has been investigated by electrochemical techniques such as electrochemical impedance spectroscopy, potentiodynamic polarization, chronoamperometry and also by the gravimetric method.
Abstract: The inhibition effect of colchicine (CC) on mild steel (MS) corrosion in 1 M HCl solution has been investigated by electrochemical techniques such as electrochemical impedance spectroscopy, potentiodynamic polarization, chronoamperometry and also by the gravimetric method. Polarization studies showed that CC acts as mixed type corrosion inhibitor. The inhibitor adsorption process in the MS/CC/HCl system was studied at different temperatures (303–333 K). The adsorption of CC on MS surface is an exothermic process and obeys the Langmuir adsorption isotherm. Based on potential of zero charge values and quantum chemical parameters, the mechanism of adsorption has been proposed.
17 citations
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TL;DR: In this article, a modified carbon paste electrode (MgO-MWCNTs-MCPE) was used for specific and simultaneous investigation of guanine (GA), adenine (AD) and epinephrine (EP).
17 citations
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TL;DR: Nine new N-(substituted azetidine-3-carbonyl)-N-methyl-hydrazino derivatives at C-7 position of fluoroquinolones were designed and synthesized through multistep synthesis and displayed good antibacterial and anti-proliferative activity.
Abstract: A series of nine new N-(substituted azetidine-3-carbonyl)-N-methyl-hydrazino derivatives at C-7 position of fluoroquinolones were designed and synthesized through multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI–MS and IR. The new compounds were tested for their in vitro antimicrobial and anti-proliferative activity. Out of the nine derivatives, compound 6i exhibited good antibacterial activity by inhibiting the growth of Methicillin-sensitive Staphylococcus aureus, Methicillin-resistant S. aureus and ATCC 35218 Escherichia coli (MIC: 0.25–16.00 μg/mL). Compounds 6c, 6g–h are displayed good growth inhibition against MCF-7 Breast carcinoma, HCT-116 Colon carcinoma and A549 Lung adenocarcinoma cell lines. Compound 6h is the most active against MCF-7 cell line with superior growth inhibition compared to ciprofloxacin and reference anticancer drug SAHA.
17 citations
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TL;DR: This study attempts to explore the antibacterial and anthelmintic properties of dehydroabietylamine, a diterpene isolated from Carthamus tinctorius L followed by the in silico elucidation of its probable mode of action.
Abstract: Background Plant-based drugs provide an outstanding contribution to modern therapeutics, and it is well known that the presence of different phytochemicals is responsible for such pharmacological effects. Carthamus tinctorius L. is one such medicinally important plant whose different solvent extracts have been reported with several pharmacological effects like antibacterial, hepatoprotective, and wound healing. The exploration of phytoconstituents from such a medicinally important plant for different pharmacological effects could produce new and effective drugs to treat human diseases. Objective The present study attempts to explore the antibacterial and anthelmintic properties of dehydroabietylamine, a diterpene isolated from Carthamus tinctorius L. followed by the in silico elucidation of its probable mode of action. Methods The minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of dehydroabietylamine were assessed against Staphylococcus aureus and Pseudomonas aeruginosa, using micro- broth dilution method. The anthelmintic activity of was determined to assess the time taken for paralysis and death of Pheretima Posthuma at different concentrations. Additionally, molecular docking study was conducted to understand the interaction between dehydroabietylamine with target proteins identified for both antibacterial and anthelmintic activity viz., glucosamine-6-phosphate synthase and β-Tubulin, respectively. Results The dehydroabietylamine showed the significant MIC for S. aureus (12.5 μg/ml) and P. aeruginosa (6.25μg/ml), respectively. The result of anthelmintics effect of dehydroabietylamine was found to be dosedependent and compared to the standard drug, albendazole. Conclusion The interactions of dehydroabietylamine with the two target proteins with high binding affinity indicated the probable inhibition of target proteins, which could be the cause for prominent antibacterial and antihelminthic effects.
17 citations
Authors
Showing all 1592 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tejraj M. Aminabhavi | 89 | 642 | 32265 |
Subburaman Mohan | 86 | 461 | 29023 |
Suresh Mathivanan | 48 | 116 | 24289 |
Raghothama Chaerkady | 40 | 85 | 8554 |
Bijjanal Jayanna Gireesha | 40 | 233 | 4748 |
Basavarajappa Mahanthesh | 38 | 158 | 3580 |
Thimmappa Venkatarangaiah Venkatesha | 34 | 149 | 3907 |
B.E. Kumara Swamy | 31 | 160 | 3416 |
Shivakumar Keerthikumar | 27 | 55 | 6557 |
Rajesh Raju | 25 | 51 | 6733 |
K. Ganesh Kumar | 24 | 64 | 1298 |
Kalappa Prashantha | 24 | 65 | 2191 |
Jayappa Manjanna | 24 | 73 | 1903 |
Kallappa M. Hosamani | 24 | 105 | 2602 |
Kumaran Kandasamy | 23 | 31 | 5921 |