Kuvempu University

About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.

DNA Binding, Molecular Docking and Antimicrobial Evaluation of Novel Azo Dye Ligand and Their Metal Complexes

Abstract: In the present work, the synthesis of novel azo dye ligand 6-hydroxy-4-methyl-2-oxo-1-propyl-5-[(E)-1,3-thiazol-2-yldiazenyl]-1,2-dihydropyridine-3-carbonitrile (L) and its Cu(II), Co(II) and Ni(II) transition complexes were prepared. The newly formed compounds were characterized by elemental analysis, UV–Vis, FT-IR, 1H NMR, LC–MS, TGA and magnetic susceptibility measurement. The molar conductance indicates that all the metal complexes are non-electrolytic in nature Based on spectral data indicate square planar geometry was deduced for Cu(II) and Ni(II) complexes, Co(II) complex has tridentate chelation of ligand and produce an octahedral geometry around the metal ion. Additionally, the computational study has been performed using density functional theory (DFT) calculation was used to study the electronic structure of synthesized ligand and their complexes. The in vitro antimicrobial activity of the azo dye ligand and its complexes was tested against Gram +ve bacteria (Bacillus subtilis), Gram –ve bacteria (Escherichia coli), yeast (Candida albicans) and fungus (Aspergillus flavus). All the complexes showed enhanced biocidal activity compared to the free ligand. Moreover, azo dye ligand and its metal complexes have been studied for their antioxidant activity. The DNA-binding activity of metal complexes (1a–1c) was studied by electronic absorption spectroscopy and fluorescence spectroscopy. All the complexes bound to CT-DNA through an intercalation mode. Additionally, all the metal complexes act as good cleavage agents against the pBR322 DNA. The computer-aided molecular docking studies of metal complexes with the receptor of GlcN-6-P synthase showed that metal complexes are potent drugs for the target enzymes.

Design, synthesis and anti-cancer evaluation of a novel series of pyrazolo [1, 5-a] pyrimidine substituted diamide derivatives

Abstract: A novel series of pyrazolo [1, 5-a] pyrimidine substituted diamides has been designed and synthesized using a linear mode multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI-MS and IR analyses. These new compounds were screened for their in vitro antiproliferative activity using an MTT assay. Out of 23 derivatives synthesized in the current study, compounds 10q, 10u and 10w showed good anticancer activity against HeLa cell line. Furthermore, these derivatives gave IC50 values of less than 10 µM against HeLa cell and were therefore more potent than the marketed anticancer drug cis-platin (17.83 µM).

Spatial distribution of major Bactrocera fruit flies attracted to methyl eugenol in different ecological zones of Goa, India

Abstract: The spatial distribution of Bactrocera fruit flies in the Goa region (west coast of India) was studied using several dispersion parameters between April 2006 and March 2008 in three ecological zones, viz. coastal, midland and upland. These zones are 10, 25 and 50 km to the east from the coastline of the Arabian Sea at an elevation of 15, 70 and 100 m above mean sea level, respectively. The dispersion parameters revealed that the population of all the fruit fly species attracted to methyl eugenol-baited traps, viz. Bactrocera dorsalis, Bactrocera caryeae, Bactrocera zonata, Bactrocera affinis and Bactrocera correcta, followed the negative binomial distribution pattern and was highly aggregated or clumped.