Kuvempu University

About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.

Synthesis, DNA binding, and oxidative cleavage studies of Fe(II) and Co(III) complexes containing bioactive ligands.

Abstract: The two complexes containing bioactive ligands of the type and [Fe(L)] (PF6)2 (1) (where L = [1-{[2-{[2-hydroxynaphthalen-1-yl)methylidine]amino}phenyl)imino] methyl}naphthalene-2-ol]) and [Co(L1L2)] (PF6)3 (2) (where L1L2 = mixed ligand of 2-seleno-4-methylquinoline and 1,10-phenanthroline in the ratio 1:2, respectively) were synthesized and structurally characterized. The DNA binding property of the complexes with calf thymus DNA has been investigated using absorption spectra, viscosity measurements, and thermal denaturation experiments. Intrinsic binding constant Kb has been estimated at room temperature. The absorption spectral studies indicate that the complexes intercalate between the base pairs of the CT-DNA tightly with intrinsic DNA binding constant of 2.8 × 105 M−1 for (1) and 4.8 × 105 M−1 for (2) in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2, respectively. The oxidative cleavage activity of (1) and (2) were studied by using gel electrophoresis and the results show that complexes have potent nuc...

Synthesis, DNA binding, docking and photocleavage studies of quinolinyl chalcones

Abstract: A series of simple quinoline–chalcone conjugates have been synthesized by Claisen–Schmidt condensation reactions of substituted acetophenones with 2-chloro-3-formyl-quinoline and evaluated for their nucleolytic activity. The structures of the synthesized quinoline–chalcone conjugates were confirmed by IR, 1H NMR, 13C NMR and mass spectral analyses. Most of the prepared compounds showed significant DNA binding and photocleavage activities. The incorporation of an electron-donating group into ring A caused a moderate increase in the DNA binding and photocleavage activities. Compounds 3c and 3d exhibited promising DNA photocleavage against pUC 19 DNA with 85% inhibition at 100 μM concentration. A structure–activity relationship analysis of these compounds was performed; compounds 3c and 3d are potential candidates for future drug discovery and development.

Nanorod TiO2 sensor for dopamine: a voltammetric study

Abstract: Nanorod shaped titanium oxide (TiO2NRs) was synthesized by the hydrothermal process in 10 M NaOH(aq.) at 120 °C. The TiO2NRs were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), infrared spectroscopy (IR) and UV-visible absorption spectroscopy (UV-vis). An electrochemical sensor for the responsive determination of dopamine (DA) was evolved by designing a carbon paste electrode (CPE) modified with titanium oxide nanorods (TiO2NRs/MCPE). The modification of the TiO2NRs using different surfactants like sodium dodecyl sulphate (SDS), cetyltrimethylammonium bromide (CTAB) and polyglycine failed to produce an impressive charge transfer and the resulting electrodes were also less sensitive for the determination of DA. However, modification with iso-octyl phenoxy polyethoxy ethanol (TX-100) improved the redox property of DA, with increased current intensity on the surface of the TiO2NRs/MCPE, showed good electrocatalytic properties and also produced an enhancement in the peak currents for DA (TiO2NRs/TX-100/MCPE). The detection limit of DA was determined from a differential pulse voltammetric (DPV) study and was found to be 42 × 10−9 M. The effect of concentration, scan rate and pH of DA was studied and a simultaneous determination of dopamine (DA), uric acid (UA), ascorbic acid (AA) and paracetamol (PA) using the TiO2NRs/TX-100/MCPE was carried out. The interference studies showed that the modified electrode exhibits excellent selectivity in the presence of a large excess of interferents and the response is fast, stable and can be applied for real sample analysis in medical, biotechnological and pharmaceutical fields.