Kuvempu University

About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.

A study on deep learning spatiotemporal models and feature extraction techniques for video understanding

Abstract: Video understanding requires abundant semantic information. Substantial progress has been made on deep learning models in the image, text, and audio domains, and notable efforts have been recently dedicated to the design of deep networks in the video domain. We discuss the state-of-the-art convolutional neural network (CNN) and its pipelines for the exploration of video features, various fusion strategies, and their performances; we also discuss the limitations of CNN for long-term motion cues and the use of sequential learning models such as long short-term memory to overcome these limitations. In addition, we address various multi-model approaches for extracting important cues and score fusion techniques from hybrid deep learning frameworks. Then, we highlight future plans in this domain, recent trends, and substantial challenges for video understanding. This survey’s objectives are to study the plethora of approaches that have been developed for solving video understanding problems, to comprehensively study spatiotemporal cues, to explore the various models that are available for solving these problems and to identify the most promising approaches.

Novel 1,3,4-oxadiazole Targets STAT3 Signaling to Induce Antitumor Effect in Lung Cancer.

Abstract: Lung cancer is the leading type of malignancy in terms of occurrence and mortality in the global context. STAT3 is an oncogenic transcription factor that is persistently activated in many types of human malignancies, including lung cancer. In the present report, new oxadiazole conjugated indazoles were synthesized and examined for their anticancer potential in a panel of cancer cell lines. Among the new compounds, 2-(3-(6-chloro-5-methylpyridin-3-yl)phenyl)-5-(1-methyl-1H-indazol-3-yl)-1,3,4-oxadiazole (CHK9) showed consistently good cytotoxicity towards lung cancer cells with IC50 values ranging between 4.8–5.1 µM. The proapoptotic effect of CHK9 was further demonstrated by Annexin-FITC staining and TUNEL assay. In addition, the effect of CHK9 on the activation of STAT3 in lung cancer cells was examined. CHK9 reduced the phosphorylation of STAT3Y705 in a dose-dependent manner. CHK9 had no effect on the activation and expression of JAK2 and STAT5. It also reduced the STAT3-dependent luciferase reporter gene expression. CHK9 increased the expression of proapoptotic (p53 and Bax) proteins and decreased the expression of the antiapoptotic (Bcl-2, Bcl-xL, BID, and ICAM-1) proteins. CHK9 displayed a significant reduction in the number of tumor nodules in the in vivo lung cancer model with suppression of STAT3 activation in tumor tissues. CHK9 did not show substantial toxicity in the normal murine model. Overall, CHK9 inhibits the growth of lung cancer cells and tumors by interfering with the STAT3 signaling pathway.

Synthesis, characterization and biological evaluation of dihydropyrimidine derivatives

Abstract: A series of dihydropyrimidines containing quinoline were prepared under conventional heating and microwave irradiation. The structures of newly synthesized compounds were established based on analytical and spectral studies. Further these compounds were evaluated for their antioxidant, antifungal and antibacterial activities. Most of the compounds showed moderate to good activity when compared with standard.