Institution
Kuvempu University
Education•Shimoga, India•
About: Kuvempu University is a education organization based out in Shimoga, India. It is known for research contribution in the topics: Cyclic voltammetry & Carbon paste electrode. The organization has 1575 authors who have published 2210 publications receiving 39755 citations. The organization is also known as: KU.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This work has shown that circulating cytokines may contribute to diagnostic biomarker panels, and a combination of multiple biomarkers may significantly increase the sensitivity and specificity of the biochemical tests aiding reliable and accurate detection of excessive alcohol intake.
Abstract: There are currently no consistent objective biochemical markers of alcohol abuse and alcoholism. Development of reliable diagnostic biomarkers that permit accurate assessment of alcohol intake and patterns of drinking is of prime importance to treatment and research fields. Diagnostic biomarker development in other diseases has demonstrated the utility of both open, systems biology, screening for biomarkers and more rational focused efforts on specific biomolecules or families of biomolecules. Long-term alcohol consumption leads to altered inflammatory cell and adaptive immune responses with associated pathologies and increased incidence of infections. This has led researchers to focus attention on identifying cytokine biomarkers in models of alcohol abuse. Alcohol is known to alter cytokine levels in plasma and a variety of tissues including lung, liver, and very importantly brain. A number of cytokine biomarker candidates have been identified, including: tumor necrosis factor-alpha, interleukin (IL)-1-alpha, IL-1-beta, IL-6, IL-8, IL-12, and monocyte chemoattractant protein-1. This is an emerging and potentially exciting avenue of research in that circulating cytokines may contribute to diagnostic biomarker panels, and a combination of multiple biomarkers may significantly increase the sensitivity and specificity of the biochemical tests aiding reliable and accurate detection of excessive alcohol intake.
161 citations
••
TL;DR: In this article, a mixture of tartaric acid and ascorbic acid was used to dissolve the LiCoO2 collected from spent lithium-ion batteries (LIBs).
160 citations
••
TL;DR: In this paper, a zinc-carbon nanotubes composite coatings were obtained from a sulphate bath containing dispersed carbon nanotube (CNTs) and electrochemical and weight loss measurements were made to find the corrosion behavior of composite coating.
Abstract: Zn–carbon nanotubes composite coatings were obtained from a sulphate bath containing dispersed carbon nanotubes (CNTs). The electrochemical and weight loss measurements were made to find the corrosion behavior of composite coating. The presence of carbon nanotubes shifts the potential of zinc deposit to more positive values. The composite coatings were porous free and the service life of coating was examined by salt spray test. The electrochemical studies revealed higher resistance of composite coatings to corrosion. The surface morphology was investigated by recording the SEM images of coating before and after corrosion. The mechanism of action against corrosion was established.
160 citations
••
TL;DR: MMCD is a practical tool for expediting the time-consuming steps of identifying and researching small molecules and is compatible with both NMR and MS data and facilitates high-throughput metabolomics investigations.
Abstract: Proteomic technologies, such as yeast two-hybrid, mass spectrometry (MS), protein/peptide arrays and fluorescence microscopy, yield multi-dimensional data sets, which are often quite large and either not published or published as supplementary information that is not easily searchable. Without a system in place for standardizing and sharing data, it is not fruitful for the biomedical community to contribute these types of data to centralized repositories.
157 citations
••
TL;DR: The largest identification of proteins from the synovial fluid of rheumatoid arthritis and osteoarthritis patients using a quantitative proteomics approach is reported.
Abstract: Rheumatoid arthritis and osteoarthritis are two common musculoskeletal disorders that affect the joints. Despite high prevalence rates, etiological factors involved in these disorders remain largely unknown. Dissecting the molecular aspects of these disorders will significantly contribute to improving their diagnosis and clinical management. In order to identify proteins that are differentially expressed between these two conditions, a quantitative proteomic profiling of synovial fluid obtained from rheumatoid arthritis and osteoarthritis patients was carried out by using iTRAQ labeling followed by high resolution mass spectrometry analysis. We have identified 575 proteins out of which 135 proteins were found to be differentially expressed by ≥3-fold in the synovial fluid of rheumatoid arthritis and osteoarthritis patients. Proteins not previously reported to be associated with rheumatoid arthritis including, coronin-1A (CORO1A), fibrinogen like-2 (FGL2), and macrophage capping protein (CAPG) were found to be upregulated in rheumatoid arthritis. Proteins such as CD5 molecule-like protein (CD5L), soluble scavenger receptor cysteine-rich domain-containing protein (SSC5D), and TTK protein kinase (TTK) were found to be upregulated in the synovial fluid of osteoarthritis patients. We confirmed the upregulation of CAPG in rheumatoid arthritis synovial fluid by multiple reaction monitoring assay as well as by Western blot. Pathway analysis of differentially expressed proteins revealed a significant enrichment of genes involved in glycolytic pathway in rheumatoid arthritis. We report here the largest identification of proteins from the synovial fluid of rheumatoid arthritis and osteoarthritis patients using a quantitative proteomics approach. The novel proteins identified from our study needs to be explored further for their role in the disease pathogenesis of rheumatoid arthritis and osteoarthritis. Sartaj Ahmad and Raja Sekhar Nirujogi contributed equally to this article.
156 citations
Authors
Showing all 1592 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tejraj M. Aminabhavi | 89 | 642 | 32265 |
Subburaman Mohan | 86 | 461 | 29023 |
Suresh Mathivanan | 48 | 116 | 24289 |
Raghothama Chaerkady | 40 | 85 | 8554 |
Bijjanal Jayanna Gireesha | 40 | 233 | 4748 |
Basavarajappa Mahanthesh | 38 | 158 | 3580 |
Thimmappa Venkatarangaiah Venkatesha | 34 | 149 | 3907 |
B.E. Kumara Swamy | 31 | 160 | 3416 |
Shivakumar Keerthikumar | 27 | 55 | 6557 |
Rajesh Raju | 25 | 51 | 6733 |
K. Ganesh Kumar | 24 | 64 | 1298 |
Kalappa Prashantha | 24 | 65 | 2191 |
Jayappa Manjanna | 24 | 73 | 1903 |
Kallappa M. Hosamani | 24 | 105 | 2602 |
Kumaran Kandasamy | 23 | 31 | 5921 |