Kwangwoon University

About: Kwangwoon University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Thin film & Resonator. The organization has 4020 authors who have published 8217 publications receiving 104365 citations.

The Influence of Cultural Individualism-Collectivism, Self Construals, and Individual Values on Communication Styles Across Cultures

Abstract: Individualism-collectivism has a direct effect on communication styles and an indirect effect that is mediated through self construals and values. It was hypothesized that cultural individualism-collectivism, self construals, and values would have separate effects on individuals’use of low- and high-context communication styles. As predicted, the results of this study suggest that independent self construals and individualistic values mediate the influence of cultural individualism-collectivism on the use of low-context communication, and interdependent self construals and collectivistic values mediate the influence of cultural individualism-collectivism on the use of high-context communication. The patterns for cultural individualism-collectivism were not as clear-cut. The findings suggest that individual level factors (i.e., self construals and values) are better predictors of low- and high-context communication styles across cultures than cultural individualism-collectivism.

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8.

Abstract: A correct alignment is an essential requirement in homology modeling. Yet in order to bridge the structural gap between template and target, which may not only involve loop rearrangements, but also shifts of secondary structure elements and repacking of core residues, high-resolution refinement methods with full atomic details are needed. Here, we describe four approaches that address this "last mile of the protein folding problem" and have performed well during CASP8, yielding physically realistic models: YASARA, which runs molecular dynamics simulations of models in explicit solvent, using a new partly knowledge-based all atom force field derived from Amber, whose parameters have been optimized to minimize the damage done to protein crystal structures. The LEE-SERVER, which makes extensive use of conformational space annealing to create alignments, to help Modeller build physically realistic models while satisfying input restraints from templates and CHARMM stereochemistry, and to remodel the side-chains. ROSETTA, whose high resolution refinement protocol combines a physically realistic all atom force field with Monte Carlo minimization to allow the large conformational space to be sampled quickly. And finally UNDERTAKER, which creates a pool of candidate models from various templates and then optimizes them with an adaptive genetic algorithm, using a primarily empirical cost function that does not include bond angle, bond length, or other physics-like terms.

Biomedical Importance of Indoles

Abstract: The indole nucleus is an important element of many natural and synthetic molecules with significant biological activity. This review covers some of the relevant and recent achievements in the biological, chemical and pharmacological activity of important indole derivatives in the areas of drug discovery and analysis.