Institution
Kyoto Pharmaceutical University
Education•Kyoto, Japan•
About: Kyoto Pharmaceutical University is a education organization based out in Kyoto, Japan. It is known for research contribution in the topics: Intestinal absorption & Stomach. The organization has 4015 authors who have published 4912 publications receiving 128816 citations. The organization is also known as: Kyoto yakka daigaku.
Topics: Intestinal absorption, Stomach, Gastric acid, Histamine, Protease
Papers published on a yearly basis
Papers
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TL;DR: The flavonoids tested now, except monohydroxy flavones, were more or less inhibitive to the superoxide anion (O2) generation in the hypoxanthine-xanthine oxidase system.
919 citations
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TL;DR: The results indicate that the importance of EDHF increases as the vessel size decreases in endothelium-dependent relaxations in the rat mesenteric circulation.
Abstract: Endothelium-dependent relaxations are achieved by a combination of endothelium-derived prostacyclin (PGI2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). However, it remains to be fully clarified whether the relative contribution of these three mechanisms to endothelium-dependent relaxations varies as a function of the vessel size. This study was designed to clarify this point. Acetylcholine (ACh)-induced endothelium-dependent relaxations were examined in isolated blood vessels taken from the aorta and the proximal and distal mesenteric arteries of the rat. The contributions of PGI2, NO, and EDHF were evaluated by the inhibitory effects of indomethacin, N omega-nitro-L-arginine methyl ester (L-NAME) in the presence of indomethacin, and KCl in the presence of indomethacin and L-NAME, respectively. The membrane potentials were recorded with microelectrodes. The expression of endothelial No synthase (eNOS) was examined by both immunostaining and immunoblotting. The contribution of PGI2 was negligible in three different-sized blood vessels. The contribution of NO was most prominent in the aorta, whereas that of EDHF was most prominent in the distal mesenteric arteries. The resting membrane potential was significantly deeper and the ACh-induced hyperpolarization was greater in the distal mesenteric arteries than those in the aorta. The expression of eNOS was the highest in the aorta and the lowest in the distal mesenteric arteries. These results indicate that the importance of EDHF increases as the vessel size decreases in endothelium-dependent relaxations in the rat mesenteric circulation.
686 citations
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TL;DR: Conditions in which mucosal injury is directly related to impairment in mucosal defense are discussed, focusing on disorders with important clinical sequelae: nonsteroidal anti-inflammatory drug (NSAID)-associated injury, which is primarily related to inhibition of cyclooxygenase-mediated PG synthesis, and stress-related mucosal disease (SRMD), which occurs with local ischemia.
644 citations
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TL;DR: To find the exact substrate specificities of three species of tripartite efflux systems of Pseudomonas aeruginosa, MexAB-OprM, MexCD- oprJ, and MexXY-OPRM, a series of isogenic mutants were constructed, each constitutively overproduced one of the three efflux system and lacked the other two.
Abstract: To find the exact substrate specificities of three species of tripartite efflux systems of Pseudomonas aeruginosa, MexAB-OprM, MexCD-OprJ, and MexXY-OprM, we constructed a series of isogenic mutants, each of which constitutively overproduced one of the three efflux systems and lacked the other two, and their isogenic mutants, which lacked all these systems. Comparison of the susceptibilities of the constructed mutants to 52 antimicrobial agents belonging to various groups suggested the following substrate specificities. All of the efflux systems extrude a wide variety of antimicrobial agent groups, i.e., quinolones, macrolides, tetracyclines, lincomycin, chloramphenicol, most penicillins (all but carbenicillin and sulbenicillin), most cephems (all but cefsulodin and ceftazidime), meropenem, and S-4661, but none of them extrude polymyxin B or imipenem. Extrusion of aminoglycosides is specific to MexXY-OprM, and extrusion of a group of the beta-lactams, i.e., carbenicillin, sulbenicillin, ceftazidime, moxalactam, and aztreonam, is specific to MexAB-OprM. Moreover, MexAB-OprM and MexCD-OprJ extrude novobiocin, cefsulodin, and flomoxef, while MexXY-OprM does not. These substrate specificities are distinct from those reported previously.
582 citations
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TL;DR: Data indicate that Ang II induces Ca2+-dependent transactivation of the EGF receptor which serves as a scaffold for pre-activated c-Src and for downstream adaptors, leading to MAPK activation in VSMC.
582 citations
Authors
Showing all 4021 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kazuwa Nakao | 128 | 1041 | 70812 |
Akira Yamamoto | 117 | 1999 | 74961 |
Ken-ichi Inui | 78 | 388 | 20017 |
Junji Konishi | 77 | 629 | 24179 |
Shun Shimohama | 77 | 382 | 20390 |
Mitsuru Hashida | 76 | 540 | 20676 |
Masayuki Yoshikawa | 76 | 608 | 21537 |
Hisashi Matsuda | 73 | 504 | 17575 |
Keiji Wakabayashi | 69 | 432 | 17467 |
Shiroh Futaki | 67 | 332 | 17374 |
Toshio Morikawa | 61 | 299 | 10434 |
Hiromu Sakurai | 55 | 260 | 9869 |
Takashi Yonetani | 54 | 219 | 9991 |
Shinya Oishi | 54 | 352 | 9495 |
Yoshiaki Kiso | 53 | 399 | 10387 |