Showing papers by "Kyoto University published in 2021"
TL;DR: The K EGG pathway maps are now integrated with network variation maps in the NETWORK database, as well as with conserved functional units of KEGG modules and reaction modules in the MODULE database, and the KO database for functional orthologs continues to be improved.
Abstract: KEGG (https://www.kegg.jp/) is a manually curated resource integrating eighteen databases categorized into systems, genomic, chemical and health information. It also provides KEGG mapping tools, which enable understanding of cellular and organism-level functions from genome sequences and other molecular datasets. KEGG mapping is a predictive method of reconstructing molecular network systems from molecular building blocks based on the concept of functional orthologs. Since the introduction of the KEGG NETWORK database, various diseases have been associated with network variants, which are perturbed molecular networks caused by human gene variants, viruses, other pathogens and environmental factors. The network variation maps are created as aligned sets of related networks showing, for example, how different viruses inhibit or activate specific cellular signaling pathways. The KEGG pathway maps are now integrated with network variation maps in the NETWORK database, as well as with conserved functional units of KEGG modules and reaction modules in the MODULE database. The KO database for functional orthologs continues to be improved and virus KOs are being expanded for better understanding of virus-cell interactions and for enabling prediction of viral perturbations.
2,087 citations
Daniel J. Klionsky1, Amal Kamal Abdel-Aziz2, Sara Abdelfatah3, Mahmoud Abdellatif4 +2980 more•Institutions (777)
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
1,129 citations
North Carolina State University1, Ritsumeikan University2, Ohio State University3, University of California, Santa Barbara4, Institute of High Performance Computing Singapore5, Pohang University of Science and Technology6, University of California, Irvine7, University of California, Riverside8, Lawrence Berkeley National Laboratory9, Kyoto University10, Yanshan University11, Chinese Academy of Sciences12
Abstract: Heterostructured materials are an emerging class of materials with superior performances that are unattainable by their conventional homogeneous counterparts. They consist of heterogeneous zones wi...
392 citations
TL;DR: In this article, the authors reported the observation of gravitational waves from two compact binary coalescences in LIGO's and Virgo's third observing run with properties consistent with neutron star-black hole (NSBH) binaries.
Abstract: We report the observation of gravitational waves from two compact binary coalescences in LIGO’s and Virgo’s third observing run with properties consistent with neutron star–black hole (NSBH) binaries. The two events are named GW200105_162426 and GW200115_042309, abbreviated as GW200105 and GW200115; the first was observed by LIGO Livingston and Virgo and the second by all three LIGO–Virgo detectors. The source of GW200105 has component masses 8.9−1.5+1.2 and 1.9−0.2+0.3M⊙ , whereas the source of GW200115 has component masses 5.7−2.1+1.8 and 1.5−0.3+0.7M⊙ (all measurements quoted at the 90% credible level). The probability that the secondary’s mass is below the maximal mass of a neutron star is 89%–96% and 87%–98%, respectively, for GW200105 and GW200115, with the ranges arising from different astrophysical assumptions. The source luminosity distances are 280−110+110 and 300−100+150Mpc , respectively. The magnitude of the primary spin of GW200105 is less than 0.23 at the 90% credible level, and its orientation is unconstrained. For GW200115, the primary spin has a negative spin projection onto the orbital angular momentum at 88% probability. We are unable to constrain the spin or tidal deformation of the secondary component for either event. We infer an NSBH merger rate density of 45−33+75Gpc−3yr−1 when assuming that GW200105 and GW200115 are representative of the NSBH population or 130−69+112Gpc−3yr−1 under the assumption of a broader distribution of component masses.
374 citations
University College of Medical Sciences1, Kyoto University2, Crozer-Keystone Health System3, Alexandria University4, Nagasaki University5, University of Split6, University of Newcastle7, Queen Mary University of London8, University of Perugia9, University College Cork10, Kobe University11, University of Twente12, Vrije Universiteit Brussel13, University of Hong Kong14, Kwame Nkrumah University of Science and Technology15, Ho Chi Minh City Medicine and Pharmacy University16, University of Bern17, University of Helsinki18, RAND Corporation19, University of Sydney20, University of Barcelona21, University of Vienna22, University of British Columbia23, Kerman Medical University24
325 citations
Harvard University1, University of Bern2, VU University Amsterdam3, University of Oxford4, Public Health Research Institute5, University of Wuppertal6, Kyoto University7, University of Amsterdam8, University of New South Wales9, University of Melbourne10, City University London11, University of Gothenburg12, Free University of Berlin13, University of Texas at Austin14, Carlos III Health Institute15, James I University16, Ohio State University17, Northwestern University18, University of Erlangen-Nuremberg19, University of Bristol20, University Hospitals Bristol NHS Foundation Trust21, Trinity College, Dublin22, University of York23, Karolinska Institutet24, Peking Union Medical College25, Linköping University26, University of Regina27, University of Sydney28, McLean Hospital29, University of Lübeck30, University of Zaragoza31, Imperial College London32, University of Nottingham33, University of Hamburg34, Oregon Research Institute35, Australian National University36, The Ohio State University Wexner Medical Center37, Hofstra University38, Stockholm University39, Hull York Medical School40, Tilburg University41, Linnaeus University42
TL;DR: In this article, the authors conducted a systematic review and IPD network meta-analysis and estimated relative treatment effect sizes across different patient characteristics through IPD-network meta-regression, and found that both guided and unguided iCBT were associated with more effectiveness as measured by PHQ-9 scores than control treatments over the short term and the long term.
Abstract: Importance Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them. Objective To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depression using patient-level information. Data Sources We searched PubMed, Embase, PsycInfo, and Cochrane Library to identify randomized clinical trials (RCTs) published up to January 1, 2019. Study Selection Eligible RCTs were those comparing guided or unguided iCBT against each other or against any control intervention in individuals with depression. Available individual patient data (IPD) was collected from all eligible studies. Depression symptom severity was assessed after treatment, 6 months, and 12 months after randomization. Data Extraction and Synthesis We conducted a systematic review and IPD network meta-analysis and estimated relative treatment effect sizes across different patient characteristics through IPD network meta-regression. Main Outcomes and Measures Patient Health Questionnaire–9 (PHQ-9) scores. Results Of 42 eligible RCTs, 39 studies comprising 9751 participants with depression contributed IPD to the IPD network meta-analysis, of which 8107 IPD were synthesized. Overall, both guided and unguided iCBT were associated with more effectiveness as measured by PHQ-9 scores than control treatments over the short term and the long term. Guided iCBT was associated with more effectiveness than unguided iCBT (mean difference [MD] in posttreatment PHQ-9 scores, −0.8; 95% CI, −1.4 to −0.2), but we found no evidence of a difference at 6 or 12 months following randomization. Baseline depression was found to be the most important modifier of the relative association for efficacy of guided vs unguided iCBT. Differences between unguided and guided iCBT in people with baseline symptoms of subthreshold depression (PHQ-9 scores 5-9) were small, while guided iCBT was associated with overall better outcomes in patients with baseline PHQ-9 greater than 9. Conclusions and Relevance In this network meta-analysis with IPD, guided iCBT was associated with more effectiveness than unguided iCBT for individuals with depression, benefits were more substantial in individuals with moderate to severe depression. Unguided iCBT was associated with similar effectiveness among individuals with symptoms of mild/subthreshold depression. Personalized treatment selection is entirely possible and necessary to ensure the best allocation of treatment resources for depression.
271 citations
TL;DR: It is found that SARS-CoV-2 replication induces a delayed interferon (IFN) response in lung epithelial cells and that IRF-3, -5, and NF-kB/p65 are the key transcription factors regulating the IFN response during Sars-Cov-2 infection.
251 citations
University of Bern1, University of London2, Emory University3, University of Florence4, University of Santiago de Compostela5, Nagasaki University6, Umeå University7, Monash University8, University of Tsukuba9, Arizona State University10, University of Buenos Aires11, University of São Paulo12, Health Canada13, University of Ottawa14, University of Los Andes15, Fudan University16, Academy of Sciences of the Czech Republic17, Czech University of Life Sciences Prague18, University of Tartu19, University of Oulu20, Finnish Meteorological Institute21, National and Kapodistrian University of Athens22, Imperial College London23, Hakim Sabzevari University24, Brunel University London25, University of Tokyo26, Harvard University27, Norwegian Institute of Public Health28, Cayetano Heredia University29, Kyoto University30, Instituto Nacional de Saúde Dr. Ricardo Jorge31, University of Porto32, University of Turin33, Seoul National University34, University of Valencia35, Swiss Tropical and Public Health Institute36, University of Basel37, National Taiwan University38, National Institutes of Health39, University of the Republic40, Ho Chi Minh City Medicine and Pharmacy University41, European Space Agency42, Potsdam Institute for Climate Impact Research43, Pablo de Olavide University44
TL;DR: In this article, the authors use empirical data from 732 locations in 43 countries to estimate the mortality burdens associated with the additional heat exposure that has resulted from recent human-induced warming, during the period 1991-2018.
Abstract: Climate change affects human health; however, there have been no large-scale, systematic efforts to quantify the heat-related human health impacts that have already occurred due to climate change. Here, we use empirical data from 732 locations in 43 countries to estimate the mortality burdens associated with the additional heat exposure that has resulted from recent human-induced warming, during the period 1991-2018. Across all study countries, we find that 37.0% (range 20.5-76.3%) of warm-season heat-related deaths can be attributed to anthropogenic climate change and that increased mortality is evident on every continent. Burdens varied geographically but were of the order of dozens to hundreds of deaths per year in many locations. Our findings support the urgent need for more ambitious mitigation and adaptation strategies to minimize the public health impacts of climate change.
250 citations
TL;DR: Kanehisa et al. as mentioned in this paper presented an updated version of KEGG Mapper, a suite of kEGG mapping tools reported previously, together with the new versions of the kegg pathway map viewer and the BRITE hierarchy viewer.
Abstract: In contrast to artificial intelligence and machine learning approaches, KEGG (https://www.kegg.jp) has relied on human intelligence to develop "models" of biological systems, especially in the form of KEGG pathway maps that are manually created by capturing knowledge from published literature. The KEGG models can then be used in biological big data analysis, for example, for uncovering systemic functions of an organism hidden in its genome sequence through the simple procedure of KEGG mapping. Here we present an updated version of KEGG Mapper, a suite of KEGG mapping tools reported previously (Kanehisa and Sato, Protein Sci 2020; 29:28-35), together with the new versions of the KEGG pathway map viewer and the BRITE hierarchy viewer. Significant enhancements have been made for BRITE mapping, where the mapping result can be examined by manipulation of hierarchical trees, such as pruning and zooming. The tree manipulation feature has also been implemented in the taxonomy mapping tool for linking KO (KEGG Orthology) groups and modules to phenotypes.
240 citations
TL;DR: The main focus is on promising chemical modification and nonmodification approaches, aiming to prospect this hot topic from novel aspects, including nanocellulose-, chemistry-, and process-oriented surface and interface engineering for advanced nano cellulosic materials.
Abstract: How do trees support their upright massive bodies? The support comes from the incredibly strong and stiff, and highly crystalline nanoscale fibrils of extended cellulose chains, called cellulose nanofibers. Cellulose nanofibers and their crystalline parts-cellulose nanocrystals, collectively nanocelluloses, are therefore the recent hot materials to incorporate in man-made sustainable, environmentally sound, and mechanically strong materials. Nanocelluloses are generally obtained through a top-down process, during or after which the original surface chemistry and interface interactions can be dramatically changed. Therefore, surface and interface engineering are extremely important when nanocellulosic materials with a bottom-up process are fabricated. Herein, the main focus is on promising chemical modification and nonmodification approaches, aiming to prospect this hot topic from novel aspects, including nanocellulose-, chemistry-, and process-oriented surface and interface engineering for advanced nanocellulosic materials. The reinforcement of nanocelluloses in some functional materials, such as structural materials, films, filaments, aerogels, and foams, is discussed, relating to tailored surface and/or interface engineering. Although some of the nanocellulosic products have already reached the industrial arena, it is hoped that more and more nanocellulose-based products will become available in everyday life in the next few years.
231 citations
National Oceanic and Atmospheric Administration1, Cooperative Institute for Research in Environmental Sciences2, University of Nantes3, British Geological Survey4, Institut de Physique du Globe de Paris5, University of Potsdam6, University of Strasbourg7, Technical University of Denmark8, University of Savoy9, ETH Zurich10, Goddard Space Flight Center11, University of Leeds12, University of Newcastle13, Austrian Academy of Sciences14, Centre National D'Etudes Spatiales15, Ramon Llull University16, Kobe University17, Nagoya University18, Complutense University of Madrid19, Geoscience Research Institute20, Max Planck Society21, China Earthquake Administration22, Kyoto University23, Chinese Academy of Sciences24
TL;DR: The International Geomagnetic Reference Field (IGRF) was adopted by the IGA Division V Working Group (V-MOD) in 2019 as discussed by the authors, which provides the equations defining the IGRF, the spherical harmonic coefficients for this thirteenth generation model, maps of magnetic declination, inclination, and total field intensity for the epoch 2020.0, and maps of their predicted rate of change for the 2020 to 2025.0 time period.
Abstract: In December 2019, the International Association of Geomagnetism and Aeronomy (IAGA) Division V Working Group (V-MOD) adopted the thirteenth generation of the International Geomagnetic Reference Field (IGRF). This IGRF updates the previous generation with a definitive main field model for epoch 2015.0, a main field model for epoch 2020.0, and a predictive linear secular variation for 2020.0 to 2025.0. This letter provides the equations defining the IGRF, the spherical harmonic coefficients for this thirteenth generation model, maps of magnetic declination, inclination and total field intensity for the epoch 2020.0, and maps of their predicted rate of change for the 2020.0 to 2025.0 time period.
TL;DR: In this paper, the authors designed NiCoFe-Prussian blue analogue (PBA) nanocages as a support for in situ dispersion and anchoring of polymetallic phosphide nanoparticles (pMP-NPs).
Abstract: The controllable synthesis of metal-based nanoclusters for heterogeneous catalytic reactions has received considerable attention. Nevertheless, manufacturing these architectures, while avoiding aggregation and retaining surface activity, remains challenging. Herein, for the first time we designed NiCoFe-Prussian blue analogue (PBA) nanocages as a support for in situ dispersion and anchoring of polymetallic phosphide nanoparticles (pMP-NPs). Benefiting from the porous surfaces and the synergistic effects between pMP-NPs and the cyano groups in PBA, the NiCoFe-P-NP@NiCoFe-PBA nanocages exhibit a significantly enhanced catalytic activity for oxygen evolution reaction (OER) with an overpotential of 223 mV at 10 mA cm-2 and a Tafel slope of 78 mV dec-1, outperforming the NiCoFe-PBA nanocubes, NiCoFe-P nanocages, NiFe-P-NP@NiFe-PBA nanocubes, and CoFe-P-NP@CoFe-PBA nanoboxes. This work not only offers the synthesis strategy of in situ anchoring pMP-NPs on PBA nanocages but also provides a new insight into optimized Gibbs free energy of OER by regulating electron transfer from metallic phosphides to PBA substrate.
Chinese Academy of Sciences1, Tsinghua University2, Potsdam Institute for Climate Impact Research3, Netherlands Environmental Assessment Agency4, Utrecht University5, University of Potsdam6, Kyoto University7, National Institute for Environmental Studies8, International Institute for Applied Systems Analysis9, European Institute10, Polytechnic University of Milan11, Joint Global Change Research Institute12
TL;DR: In this article, the authors conducted a multimodel study and found that the 1.5°C-consistent goal would require China to reduce its carbon emissions and energy consumption by more than 90 and 39%, respectively, compared with the "no policy" case.
Abstract: Given the increasing interest in keeping global warming below 1.5°C, a key question is what this would mean for China's emission pathway, energy restructuring, and decarbonization. By conducting a multimodel study, we find that the 1.5°C-consistent goal would require China to reduce its carbon emissions and energy consumption by more than 90 and 39%, respectively, compared with the "no policy" case. Negative emission technologies play an important role in achieving near-zero emissions, with captured carbon accounting on average for 20% of the total reductions in 2050. Our multimodel comparisons reveal large differences in necessary emission reductions across sectors, whereas what is consistent is that the power sector is required to achieve full decarbonization by 2050. The cross-model averages indicate that China's accumulated policy costs may amount to 2.8 to 5.7% of its gross domestic product by 2050, given the 1.5°C warming limit.
Bose Corporation1, Cardiff University2, Durham University3, Adam Mickiewicz University in Poznań4, Max Planck Society5, Katholieke Universiteit Leuven6, Delft University of Technology7, Georgia Institute of Technology8, Kaiserslautern University of Technology9, Beihang University10, École Polytechnique Fédérale de Lausanne11, Saratov State University12, Paris-Sorbonne University13, The Catholic University of America14, University of Notre Dame15, University of Münster16, Emory University17, Polytechnic University of Milan18, Dresden University of Technology19, Helmholtz-Zentrum Dresden-Rossendorf20, University of Exeter21, Donetsk National University22, SRM University23, National University of Singapore24, University of Greifswald25, Kyoto University26, Tohoku University27, Federico Santa María Technical University28, University of Santiago, Chile29, University of Perugia30, Université Paris-Saclay31, University of Manitoba32, University of Colorado Colorado Springs33, University of Tokyo34, University of Groningen35, Technische Universität München36, Technical University of Dortmund37, University of Vienna38, Aalto University39, University of California, Riverside40, Intel41, University of Duisburg-Essen42, University of Oldenburg43
TL;DR: The Roadmap on Magnonics as mentioned in this paper is a collection of 22 sections written by leading experts in this field who review and discuss the current status but also present their vision of future perspectives.
Abstract: Magnonics is a rather young physics research field in nanomagnetism and nanoscience that addresses the use of spin waves (magnons) to transmit, store, and process information. After several papers and review articles published in the last decade, with a steadily increase in the number of citations, we are presenting the first Roadmap on Magnonics. This a collection of 22 sections written by leading experts in this field who review and discuss the current status but also present their vision of future perspectives. Today, the principal challenges in applied magnonics are the excitation of sub-100 nm wavelength magnons, their manipulation on the nanoscale and the creation of sub-micrometre devices using low-Gilbert damping magnetic materials and the interconnections to standard electronics. In this respect, magnonics offers lower energy consumption, easier integrability and compatibility with CMOS structure, reprogrammability, shorter wavelength, smaller device features, anisotropic properties, negative group velocity, non-reciprocity and efficient tunability by various external stimuli to name a few. Hence, despite being a young research field, magnonics has come a long way since its early inception. This Roadmap represents a milestone for future emerging research directions in magnonics and hopefully it will be followed by a series of articles on the same topic.
TL;DR: This paper aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available.
Abstract: Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.
TL;DR: The updated taxonomy of Negarnaviricota is presented, as now accepted by the ICTV, after the phylum was amended and emended in March 2020.
Abstract: In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
TL;DR: ASAP-seq as discussed by the authors uses a bridging approach that repurposes antibody:oligonucleotide conjugates designed for existing technologies that pair protein measurements with single-cell RNA sequencing.
Abstract: Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antigen profiling by sequencing (ASAP-seq), a tool to simultaneously profile accessible chromatin and protein levels. Our approach pairs sparse scATAC-seq data with robust detection of hundreds of cell surface and intracellular protein markers and optional capture of mitochondrial DNA for clonal tracking, capturing three distinct modalities in single cells. ASAP-seq uses a bridging approach that repurposes antibody:oligonucleotide conjugates designed for existing technologies that pair protein measurements with single-cell RNA sequencing. Together with DOGMA-seq, an adaptation of CITE-seq (cellular indexing of transcriptomes and epitopes by sequencing) for measuring gene activity across the central dogma of gene regulation, we demonstrate the utility of systematic multi-omic profiling by revealing coordinated and distinct changes in chromatin, RNA and surface proteins during native hematopoietic differentiation and peripheral blood mononuclear cell stimulation and as a combinatorial decoder and reporter of multiplexed perturbations in primary T cells.
TL;DR: In this paper, the authors consider a 2D de Sitter JT gravity coupled to a CFT, and entangled with matter in a disjoint non-gravitating universe.
Abstract: We consider black holes in 2d de Sitter JT gravity coupled to a CFT, and entangled with matter in a disjoint non-gravitating universe. Tracing out the entangling matter leaves the CFT in a density matrix whose stress tensor backreacts on the de Sitter geometry, lengthening the wormhole behind the black hole horizon. Naively, the entropy of the entangling matter increases without bound as the strength of the entanglement increases, but the monogamy property predicts that this growth must level off. We compute the entropy via the replica trick, including wormholes between the replica copies of the de Sitter geometry, and find a competition between conventional field theory entanglement entropy and the surface area of extremal “islands” in the de Sitter geometry. The black hole and cosmological horizons both play a role in generating such islands in the backreacted geometry, and have the effect of stabilizing the entropy growth as required by monogamy. We first show this in a scenario in which the de Sitter spatial section has been decompactified to an interval. Then we consider the compact geometry, and argue for a novel interpretation of the island formula in the context of closed universes that recovers the Page curve. Finally, we comment on the application of our construction to the cosmological horizon in empty de Sitter space.
TL;DR: In this article, the authors report results of a search for an isotropic gravitational-wave background (GWB) using data from Advanced LIGO's and Advanced Virgo's third observing run (O3) combined with upper limits from the earlier O1 and O2 runs.
Abstract: We report results of a search for an isotropic gravitational-wave background (GWB) using data from Advanced LIGO’s and Advanced Virgo’s third observing run (O3) combined with upper limits from the earlier O1 and O2 runs. Unlike in previous observing runs in the advanced detector era, we include Virgo in the search for the GWB. The results of the search are consistent with uncorrelated noise, and therefore we place upper limits on the strength of the GWB. We find that the dimensionless energy density
Ω
GW
≤
5.8
×
10
−
9
at the 95% credible level for a flat (frequency-independent) GWB, using a prior which is uniform in the log of the strength of the GWB, with 99% of the sensitivity coming from the band 20–76.6 Hz;
Ω
GW
(
f
)
≤
3.4
×
10
−
9
at 25 Hz for a power-law GWB with a spectral index of
2
/
3
(consistent with expectations for compact binary coalescences), in the band 20–90.6 Hz; and
Ω
GW
(
f
)
≤
3.9
×
10
−
10
at 25 Hz for a spectral index of 3, in the band 20–291.6 Hz. These upper limits improve over our previous results by a factor of 6.0 for a flat GWB, 8.8 for a spectral index of
2
/
3
, and 13.1 for a spectral index of 3. We also search for a GWB arising from scalar and vector modes, which are predicted by alternative theories of gravity; we do not find evidence of these, and place upper limits on the strength of GWBs with these polarizations. We demonstrate that there is no evidence of correlated noise of magnetic origin by performing a Bayesian analysis that allows for the presence of both a GWB and an effective magnetic background arising from geophysical Schumann resonances. We compare our upper limits to a fiducial model for the GWB from the merger of compact binaries, updating the model to use the most recent data-driven population inference from the systems detected during O3a. Finally, we combine our results with observations of individual mergers and show that, at design sensitivity, this joint approach may yield stronger constraints on the merger rate of binary black holes at
z
≳
2
than can be achieved with individually resolved mergers alone.
Duke University1, Kyoto University2, University of Tsukuba3, Liverpool John Moores University4, University of Oslo5, University of California, Los Angeles6, Ibn Tofail University7, Kwame Nkrumah University of Science and Technology8, Maastricht University9, University of Wisconsin-Madison10, University of Strasbourg11, Philips12, University of Lausanne13, Vanderbilt University14, Baylor College of Medicine15, RMIT University16, Tufts University17, Norwegian School of Sport Sciences18, University of California, Irvine19, Humboldt University of Berlin20, University of the West Indies21, University of Glasgow22, University of California, Santa Barbara23, University of Aberdeen24, Chinese Academy of Sciences25, Pennington Biomedical Research Center26, Northwestern University27, University of Cape Town28, Imperial College London29, University of Agder30, Burton Snowboards31, Fred Hutchinson Cancer Research Center32, Moi University33, Helsinki University Central Hospital34, University of Brighton35, University of Edinburgh36, Washington University in St. Louis37, University of Southern California38, Tilburg University39, University of Copenhagen40, Stanford University41, Baylor University42, UCL Institute of Child Health43, Max Planck Society44, International Atomic Energy Agency45, Loyola University Chicago46, Maastricht University Medical Centre47
TL;DR: In this article, the authors analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years and found that fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults.
Abstract: Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
TL;DR: In this paper, upadacitinib plus topical corticosteroids compared with placebo for the treatment of moderate-to-severe atopic dermatitis was evaluated in a randomized, double-blind, placebo-controlled, phase 3 trial.
Université libre de Bruxelles1, Breast International Group2, Hoffmann-La Roche3, University of Texas MD Anderson Cancer Center4, Duke University5, Garvan Institute of Medical Research6, University of Bordeaux7, Harvard University8, National Health Research Institutes9, Kyoto University10, Westmead Hospital11, University of Sydney12, Samsung Medical Center13, Taipei Veterans General Hospital14, Praxis15, European Institute of Oncology16, Martin Luther University of Halle-Wittenberg17
TL;DR: PURPOSEAPHINITY, at 45 months median follow-up, showed that pertuzumab added to adjuvant trastuzumaab and chemotherapy significantly improved invasive disease-free survival (IDFS) (hazard ratio 081).
Abstract: PURPOSEAPHINITY, at 45 months median follow-up, showed that pertuzumab added to adjuvant trastuzumab and chemotherapy significantly improved invasive disease–free survival (IDFS) (hazard ratio 081
TL;DR: These examples demonstrate unique synthetic potentials of structurally strained four-membered ring compounds for the construction of organic skeletons, and the progress of catalytic reactions involving oxidative addition of carbon-carbon bonds onto transition metals or β-carbon elimination of transition metal alkoxides.
Abstract: This article reviews synthetic transformations involving cleavage of a carbon–carbon bond of a four-membered ring, with a particular focus on the examples reported during the period from 2011 to th...
TL;DR: KAGRA as discussed by the authors is a newly built gravitational-wave telescope, a laser interferometer comprising arms with a length of 3 km, located in Kamioka, Gifu, Japan.
Abstract: KAGRA is a newly built gravitational-wave telescope, a laser interferometer comprising arms with a length of 3\,km, located in Kamioka, Gifu, Japan. KAGRA was constructed under the ground and it is operated using cryogenic mirrors that help in reducing the seismic and thermal noise. Both technologies are expected to provide directions for the future of gravitational-wave telescopes. In 2019, KAGRA finished all installations with the designed configuration, which we call the baseline KAGRA. In this occasion, we present an overview of the baseline KAGRA from various viewpoints in a series of of articles. In this article, we introduce the design configurations of KAGRA with its historical background.
TL;DR: In this article, the ATLAS particle-flow reconstruction method is used to reconstruct the topo-clusters of the proton-proton collision data with a center-of-mass energy of 13$ TeV collected by the LHC.
Abstract: Jet energy scale and resolution measurements with their associated uncertainties are reported for jets using 36-81 fb$^{-1}$ of proton-proton collision data with a centre-of-mass energy of $\sqrt{s}=13$ TeV collected by the ATLAS detector at the LHC. Jets are reconstructed using two different input types: topo-clusters formed from energy deposits in calorimeter cells, as well as an algorithmic combination of charged-particle tracks with those topo-clusters, referred to as the ATLAS particle-flow reconstruction method. The anti-$k_t$ jet algorithm with radius parameter $R=0.4$ is the primary jet definition used for both jet types. Jets are initially calibrated using a sequence of simulation-based corrections. Next, several $\textit{in situ}$ techniques are employed to correct for differences between data and simulation and to measure the resolution of jets. The systematic uncertainties in the jet energy scale for central jets ($|\eta| 2.5$ TeV). The relative jet energy resolution is measured and ranges from ($24 \pm 1.5$)% at 20 GeV to ($6 \pm 0.5$)% at 300 GeV.
TL;DR: In this paper, a review of particle methods in hydrodynamics-related problems in ocean and coastal engineering is presented, where the problems are placed into three categories according to their physical characteristics, namely, wave hydrodynamic and corresponding mass transport, wave-structure interaction, and wave-current-sediment interaction.
TL;DR: In this article, the zero-field muon spin relaxation (ZF-spin relaxation) was measured on strontium ruthenate samples under uniaxial stresses.
Abstract: Strontium ruthenate (Sr2RuO4) continues to present an important test of our understanding of unconventional superconductivity, because while its normal-state electronic structure is known with precision, its superconductivity remains unexplained. There is evidence that its order parameter is chiral, but reconciling this with recent observations of the spin part of the pairing requires an order parameter that is either finely tuned or implies a new form of pairing. Therefore, a definitive resolution of whether the superconductivity of Sr2RuO4 is chiral is important for the study of superconductivity. Here we report the measurement of zero-field muon spin relaxation—a probe sensitive to weak magnetism—on samples under uniaxial stresses. We observe stress-induced splitting between the onset temperatures of superconductivity and time-reversal symmetry breaking—consistent with the qualitative expectations for a chiral order parameter—and argue that this observation cannot be explained by conventional magnetism. In addition, we report the appearance of bulk magnetic order under higher uniaxial stress, above the critical pressure at which a Lifshitz transition occurs in Sr2RuO4. When strain is applied to strontium ruthenate, superconductivity emerges at a different temperature to the breaking of time-reversal symmetry. This indicates that the superconductivity could have a chiral d-wave order parameter.
TL;DR: In this article, the authors highlight rational design strategies for highly proton-conductive porous metal-organic frameworks (MOFs) in terms of MOF components, with representative examples from recent years.
Abstract: Since the transition of energy platforms, proton-conducting materials have played a significant role in broad applications for electrochemical devices. In particular, solid-state proton conductors (SSPCs) are emerging as the electrolyte in fuel cells (FC), a promising power generation technology, because of their high performance and safety for operating in a wide range of temperatures. In recent years, proton-conductive porous metal-organic frameworks (MOFs) exhibiting high proton-conducting properties (>10-2 S cm-1) have been extensively investigated due to their potential application in solid-state electrolytes. Their structural designability, crystallinity, and porosity are beneficial to fabricate a new type of proton conductor, providing a comprehensive conduction mechanism. For the proton-conductive MOFs, each component, such as the metal centres, organic linkers, and pore space, is manipulated by a judicious predesign strategy or post-synthetic modification to improve the mobile proton concentration with an efficient conducting pathway. In this review, we highlight rational design strategies for highly proton-conductive MOFs in terms of MOF components, with representative examples from recent years. Subsequently, we discuss the challenges and future directions for the design of proton-conductive MOFs.
TL;DR: The in vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pick's disease, PSP, and corticobasal degeneration patients who underwent PET scans.
Chosun University1, University of North Carolina at Chapel Hill2, Chonnam National University3, Asan Medical Center4, Dong-A University Hospital5, Korea University6, Peking University7, Nanjing Medical University8, Tokai University9, Kyoto University10, National Taiwan University11, Semmelweis University12, University of Tübingen13, University of Hertfordshire14, National Institutes of Health15, University of Liverpool16, University of Florida17, Gyeongsang National University18
TL;DR: New evidence and future directions of antithrombotic treatment in East Asian patients are proposed and the unique risk-benefit trade-off in East Asians is proposed.
Abstract: East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk–benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.