Institution
Kyoto University
Education•Kyoto, Japan•
About: Kyoto University is a education organization based out in Kyoto, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 85837 authors who have published 217215 publications receiving 6526826 citations. The organization is also known as: Kyōto University & Kyōto daigaku.
Topics: Population, Catalysis, Transplantation, Polymerization, Gene
Papers published on a yearly basis
Papers
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TL;DR: The results indicate that at least two types of calcium channel mediate synaptic transmission in the mammalian central nervous system.
Abstract: Synaptic transmission is mediated by calcium entry through voltage-dependent calcium channels in presynaptic nerve terminals. Various types of calcium channel have been characterized in neuronal somata, but it is not clear which subtypes induce transmitter release at central synapses. The N-type Ca2+ channel blocker omega-conotoxin GVIA (omega-CgTx) suppresses the excitatory postsynaptic responses only partially, whereas potassium-induced release of glutamate from brain synaptosomes can be blocked by omega-Aga-VIA (ref. 9), a blocker of P-type calcium channels and possibly of other types of calcium channels. Here we test type-specific calcium-channel blockers on postsynaptic currents recorded from neurons in thin slices of rat central nervous system. Inhibitory postsynaptic currents in cerebellar and spinal neurons and excitatory postsynaptic currents in hippocampal neurons are markedly suppressed by omega-Aga-IVA and reduced to a lesser extent by omega-CgTx. The L-type calcium channel blocker nicardipine had no effect. Our results indicate that at least two types of calcium channel mediate synaptic transmission in the mammalian central nervous system.
732 citations
TL;DR: In this article, it was shown that extended gravity theories, the Lagrangian of which is an arbitrary function of scalar curvature R, are equivalent to a class of the scalar-tensor theories of gravity.
731 citations
TL;DR: It is shown that the uptake of octa-arginine (R8) peptide by HeLa cells was significantly suppressed by the macropinocytosis inhibitor ethylisopropylamiloride (EIPA) and the F-actin polymerization inhibitor cytochalasin D, suggesting a role for macrop inocytotic in the uptake and suggesting that penetratin and R8 peptides have distinct internalization mechanisms.
731 citations
TL;DR: Results show that N-cadherin plays a critical role in early heart development as well as in other morphogenetic processes, and in vitro studies of cardiac myocytes derived from N- cadher in mutant embryos show that the cells can loosely aggregate and beat synchronously.
729 citations
Emory University1, Harvard University2, University of Tennessee3, Wakayama Medical University4, University of British Columbia5, Mayo Clinic6, University of Verona7, Tokyo Medical University8, Ohio State University9, Tokyo Metropolitan Komagome Hospital10, Shinshu University11, Kanazawa University12, University of Ulsan13, Kyoto University14, Yokohama City University15, University of Greifswald16, Karolinska Institutet17, Kanazawa Medical University18, University of Toyama19, Kyushu University20, Nagoya City University21, Kansai Medical University22, Aix-Marseille University23, Tohoku University24, Sapporo Medical University25, Teikyo University26, University College London27, Peking Union Medical College28
TL;DR: A. H. Wallace, J. L. Carruthers, S. L€ ohr, Y. Khosroshahi, Z. Chari, E. Della-Torre, L. Frulloni, H.
Abstract: A. Khosroshahi, Z. S. Wallace, J. L. Crowe, T. Akamizu, A. Azumi, M. N. Carruthers, S. T. Chari, E. Della-Torre, L. Frulloni, H. Goto, P. A. Hart, T. Kamisawa, S. Kawa, M. Kawano, M. H. Kim, Y. Kodama, K. Kubota, M. M. Lerch, M. L€ ohr, Y. Masaki, S. Matsui, T. Mimori, S. Nakamura, T. Nakazawa, H. Ohara, K. Okazaki, J. H. Ryu, T. Saeki, N. Schleinitz, A. Shimatsu, T. Shimosegawa, H. Takahashi, M. Takahira, A. Tanaka, M. Topazian, H. Umehara, G. J. Webster, T. E. Witzig, M. Yamamoto, W. Zhang, T. Chiba, and J. H. Stone
728 citations
Authors
Showing all 86225 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Kari Alitalo | 174 | 817 | 114231 |
| Ralph M. Steinman | 171 | 453 | 121518 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Karl Deisseroth | 160 | 556 | 101487 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Takashi Taniguchi | 152 | 2141 | 110658 |
| Ben Zhong Tang | 149 | 2007 | 116294 |
| Takeo Kanade | 147 | 799 | 103237 |
| Yuji Matsuzawa | 143 | 836 | 116711 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Kenneth M. Yamada | 139 | 446 | 72136 |
| Y. B. Hsiung | 138 | 1258 | 94278 |
| Shuh Narumiya | 137 | 595 | 70183 |
| Kevin P. Campbell | 137 | 521 | 60854 |
| Junji Tojo | 135 | 878 | 84615 |