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Institution

Kyoto University

EducationKyoto, Japan
About: Kyoto University is a education organization based out in Kyoto, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 85837 authors who have published 217215 publications receiving 6526826 citations. The organization is also known as: Kyōto University & Kyōto daigaku.


Papers
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Journal ArticleDOI
TL;DR: The integrals of polynomial functions with respect to the Haar measure on the unitary group U(d) have been studied in this paper for all values of d.
Abstract: We revisit the work of the first named author and using simpler algebraic arguments we calculate integrals of polynomial functions with respect to the Haar measure on the unitary group U(d). The previous result provided exact formulas only for 2d bigger than the degree of the integrated polynomial and we show that these formulas remain valid for all values of d. Also, we consider the integrals of polynomial functions on the orthogonal group O(d) and the symplectic group Sp(d). We obtain an exact character expansion and the asymptotic behavior for large d. Thus we can show the asymptotic freeness of Haar-distributed orthogonal and symplectic random matrices, as well as the convergence of integrals of the Itzykson–Zuber type.

690 citations

Journal ArticleDOI
TL;DR: It is shown here that degradation of misfolded glycoprotein substrates requires transcriptional induction of EDEM (ER degradation-enhancing alpha-mannosidase-like protein), and that this is mediated specifically by IRE1-XBP1 and not by ATF6.

690 citations

Journal ArticleDOI
TL;DR: It is demonstrated that individual dopaminergic neurons of the substantia nigra can broadcast a dopamine signal and exert strong influence over a large number of striatal neurons and suggests that neurodegeneration of individual nigral neurons can affect multiple neurons in the striatum.
Abstract: The axonal arbors of single nigrostriatal dopaminergic neurons were visualized with a viral vector expressing membrane-targeted green fluorescent protein in rat brain. All eight reconstructed tyrosine hydroxylase-positive dopaminergic neurons possessed widely spread and highly dense axonal arborizations in the neostriatum. All of them emitted very little axon collateral arborization outside of the striatum except for tiny arborization in the external pallidum. The striatal axonal bush of each reconstructed dopaminergic neuron covered 0.45-5.7% (mean +/- SD = 2.7 +/- 1.5%) of the total volume of the neostriatum. Furthermore, all the dopaminergic neurons innervated both striosome and matrix compartments of the neostriatum, although each neuron's arborization tended to favor one of these compartments. Our findings demonstrate that individual dopaminergic neurons of the substantia nigra can broadcast a dopamine signal and exert strong influence over a large number of striatal neurons. This divergent signaling should be a key to the function of the nigrostriatal system in dopamine-based learning and suggests that neurodegeneration of individual nigral neurons can affect multiple neurons in the striatum. Thus, these results would also contribute to understanding the clinicopathology of Parkinson's disease and related syndromes.

687 citations

Journal ArticleDOI
Markus Ackermann, Marco Ajello1, W. B. Atwood2, Luca Baldini3  +176 moreInstitutions (36)
TL;DR: In this paper, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmicray confinement volume (halo), and distribution of interstellar gas.
Abstract: The gamma-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi-LAT mission and compare with models of the diffuse gamma-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas and radiation fields. To assess uncertainties associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the Xco-factor, the ratio between integrated CO-line intensity and molecular hydrogen column density, the fluxes and spectra of the gamma-ray point sources from the first Fermi-LAT catalogue, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as gamma rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum likelihood ratios as well as spectra, longitude, and latitude profiles. We also provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but under-predict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point source populations and spectral variations of cosmic rays throughout the Galaxy.

686 citations


Authors

Showing all 86225 results

NameH-indexPapersCitations
Kari Alitalo174817114231
Ralph M. Steinman171453121518
Masayuki Yamamoto1711576123028
Karl Deisseroth160556101487
Kenji Kangawa1531117110059
Takashi Taniguchi1522141110658
Ben Zhong Tang1492007116294
Takeo Kanade147799103237
Yuji Matsuzawa143836116711
Tasuku Honjo14171288428
Kenneth M. Yamada13944672136
Y. B. Hsiung138125894278
Shuh Narumiya13759570183
Kevin P. Campbell13752160854
Junji Tojo13587884615
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023234
2022679
20218,533
20208,740
20198,050
20187,932