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Institution

Kyoto University

EducationKyoto, Japan
About: Kyoto University is a education organization based out in Kyoto, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 85837 authors who have published 217215 publications receiving 6526826 citations. The organization is also known as: Kyōto University & Kyōto daigaku.


Papers
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Journal ArticleDOI
TL;DR: These findings suggest that immature osteoblasts and endothelial cells control stem cell homing, retention, and repopulation by secreting SDF-1, which also participates in host defense responses to DNA damage.
Abstract: The chemokine stromal-derived factor-1 (SDF-1) controls many aspects of stem cell function. Details of its regulation and sites of production are currently unknown. We report that in the bone marrow, SDF-1 is produced mainly by immature osteoblasts and endothelial cells. Conditioning with DNA-damaging agents (ionizing irradiation, cyclophosphamide, and 5-fluorouracil) caused an increase in SDF-1 expression and in CXCR4-dependent homing and repopulation by human stem cells transplanted into NOD/SCID mice. Our findings suggest that immature osteoblasts and endothelial cells control stem cell homing, retention, and repopulation by secreting SDF-1, which also participates in host defense responses to DNA damage.

609 citations

Journal ArticleDOI
01 Apr 2010-Cancer
TL;DR: Investigation of the mechanism underlining the immunosuppression of melanoma patients focused on programmed cell death‐1/PD‐1 ligand 1 (PD‐L1) interaction between tumor cells and T cells.
Abstract: BACKGROUND: Melanoma tends to be refractory to various immunotherapies because of tumor-induced immunosuppression. To investigate the mechanism underlining the immunosuppression of melanoma patients, the authors focused on programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) interaction between tumor cells and T cells. METHODS: Melanoma specimens were collected from 59 primary tumors, 16 lymph nodes, and 4 lesions of in-transit metastasis. Specimens stained with anti-PD-L1 monoclonal antibodies were digitalized to jpg files. To evaluate the intensity of PD-L1 expression, histograms were used, and the red density (RD) was measured. PD-1 expression on T cells was analyzed in blood samples from 10 patients who had stage IV melanoma and in 4 samples of in-transit metastases. RESULTS: Twenty-five patients comprised the ‘‘low’’ PD-L1 expression group (RD value, <90), and 34 patients comprised the ‘‘high’’ group (RD value, � 90). Breslow tumor thickness in the high-expression group was significantly higher than in the low-expression group. Univariate and multivariate analyses revealed that the overall survival rate of the high-expression group was significantly lower than that of the low-expression group. In all patients with stage IV disease who were examined, both CD8-positive and CD4-positive T cells had significantly higher PD-1 expression levels in the peripheral blood. Tumor-infiltrating T cells expressed high levels of PD-1, and its expression was elevated further during the clinical course. CONCLUSIONS: The current results indicated that there is a correlation between the degree of PD-L1 expression and the vertical growth of primary tumors in melanoma. Multivariate analysis demonstrated that PD-L1 expression is an independent prognostic factor for melanoma. Cancer 2010;116:1757–66. V C 2010 American Cancer Society.

609 citations

Journal ArticleDOI
TL;DR: Results suggest that FGF10 acts as a major ligand for FGFR2b in mouse multi-organ development, which would indicate a role for FGF12 in wide-range organogenesis.

608 citations

Journal ArticleDOI
Georges Aad1, T. Abajyan2, Brad Abbott3, Jalal Abdallah  +2942 moreInstitutions (201)
TL;DR: In this paper, the spin and parity quantum numbers of the Higgs boson were studied based on the collision data collected by the ATLAS experiment at the LHC, and the results showed that the standard model spin-parity J(...

608 citations

Journal ArticleDOI
TL;DR: In this article, it is argued that although most conceptions of personality in academic psychology are rooted in a model of the person as independent, in many Asian cultures, personality is constructed on the basis of an alternative model of a person as interdependent.
Abstract: Research in cultural psychology suggests that person is a social and collective construction made possible through an individual's participation in the practices and meanings of a given cultural context. This perspective can make a contribution to some contemporary controversies in personality. In the current article, it is argued that although most conceptions of personality in academic psychology are rooted in a model of the person as independent, in many Asian cultures, personality is constructed on the basis of an alternative model of the person as interdependent. In these cultures, then, personality is experienced and understood as behavior that is characteristic of the person in relationship with others in particular social contexts. Some initial evidence is reviewed and questions for future research are suggested.

608 citations


Authors

Showing all 86225 results

NameH-indexPapersCitations
Kari Alitalo174817114231
Ralph M. Steinman171453121518
Masayuki Yamamoto1711576123028
Karl Deisseroth160556101487
Kenji Kangawa1531117110059
Takashi Taniguchi1522141110658
Ben Zhong Tang1492007116294
Takeo Kanade147799103237
Yuji Matsuzawa143836116711
Tasuku Honjo14171288428
Kenneth M. Yamada13944672136
Y. B. Hsiung138125894278
Shuh Narumiya13759570183
Kevin P. Campbell13752160854
Junji Tojo13587884615
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023234
2022679
20218,533
20208,740
20198,050
20187,932