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Institution

Kyoto University

EducationKyoto, Japan
About: Kyoto University is a education organization based out in Kyoto, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 85837 authors who have published 217215 publications receiving 6526826 citations. The organization is also known as: Kyōto University & Kyōto daigaku.


Papers
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Journal ArticleDOI
TL;DR: It is demonstrated that there is an additional mGLUR subtype which closely resembles mGluR1 in its signal transduction and pharmacological properties and is expressed in specialized neuronal cells in the central nervous system.

880 citations

Journal ArticleDOI
TL;DR: The use of small-for-size grafts (less than 1% of recipient body weight) leads to lower graft survival, probably through enhanced parenchymal cell injury and reduced metabolic and synthetic capacity.
Abstract: Background. Although living donor liver transplantation for small pediatric patients is increasingly accepted, its expansion to older/larger patients is still in question because of the lack of sufficient information on the impact of graft size mismatching. Methods. A total of 276 cases of living donor liver transplantation, excluding ABO-incompatible, auxiliary, or secondary transplants, were reviewed from graft size matching. Forty-three cases were highly urgent cases receiving intensive care preoperatively. Cases were categorized into five groups by graft-to-recipient weight ratio (GRWR): extra-small-for-size (XS; GRWR<0.8%, 17 elective and 4 urgent cases), small (S; 0.8

878 citations

Journal ArticleDOI
Y. Fukuda1, M. Ishitsuka1, Yoshitaka Itow1, Takaaki Kajita1, J. Kameda1, K. Kaneyuki1, K. Kobayashi1, Yusuke Koshio1, M. Miura1, S. Moriyama1, Masayuki Nakahata1, S. Nakayama1, A. Okada1, N. Sakurai1, Masato Shiozawa1, Yoshihiro Suzuki1, H. Takeuchi1, Y. Takeuchi1, T. Toshito1, Y. Totsuka1, Shoichi Yamada1, Shantanu Desai2, M. Earl2, E. Kearns2, M. D. Messier2, Kate Scholberg2, Kate Scholberg3, J. L. Stone2, L. R. Sulak2, C. W. Walter2, M. Goldhaber4, T. Barszczak5, David William Casper5, W. Gajewski5, W. R. Kropp5, S. Mine5, D. W. Liu5, L. R. Price5, M. B. Smy5, Henry W. Sobel5, M. R. Vagins5, Todd Haines5, D. Kielczewska5, K. S. Ganezer6, W. E. Keig6, R. W. Ellsworth7, S. Tasaka8, A. Kibayashi, John G. Learned, S. Matsuno, D. Takemori, Y. Hayato, T. Ishii, Takashi Kobayashi, Koji Nakamura, Y. Obayashi, Y. Oyama, A. Sakai, Makoto Sakuda, M. Kohama9, Atsumu Suzuki9, T. Inagaki10, Tsuyoshi Nakaya10, K. Nishikawa10, E. Blaufuss11, S. Dazeley11, R. Svoboda11, J. A. Goodman12, G. Guillian12, G. W. Sullivan12, D. Turcan12, Alec Habig13, J. Hill14, C. K. Jung14, K. Martens14, K. Martens15, Magdalena Malek14, C. Mauger14, C. McGrew14, E. Sharkey14, B. Viren14, C. Yanagisawa14, C. Mitsuda16, K. Miyano16, C. Saji16, T. Shibata16, Y. Kajiyama17, Y. Nagashima17, K. Nitta17, M. Takita17, Minoru Yoshida17, Heekyong Kim18, Soo-Bong Kim18, J. Yoo18, H. Okazawa, T. Ishizuka19, M. Etoh20, Y. Gando20, Takehisa Hasegawa20, Kunio Inoue20, K. Ishihara20, Tomoyuki Maruyama20, J. Shirai20, A. Suzuki20, Masatoshi Koshiba1, Y. Hatakeyama21, Y. Ichikawa21, M. Koike21, Kyoshi Nishijima21, H. Fujiyasu22, Hirokazu Ishino22, M. Morii22, Y. Watanabe22, U. Golebiewska23, S. C. Boyd24, A. L. Stachyra24, R. J. Wilkes24, B. Lee 
TL;DR: Solar neutrino measurements from 1258 days of data from the Super-Kamiokande detector are presented and the recoil electron energy spectrum is consistent with no spectral distortion.
Abstract: Solar neutrino measurements from 1258days of data from the Super-Kamiokande detector are presented. The measurements are based on recoil electrons in the energy range 5.0{endash}20.0MeV. The measured solar neutrino flux is 2.32{+-}0.03(stat){sup +0.08}{sub {minus}0.07}(syst){times}10{sup 6} cm{sup {minus}2}s{sup {minus}1} , which is 45.1{+-}0.5(stat ){sup +1.6}{sub {minus}1.4}(syst) % of that predicted by the BP2000 SSM. The day vs night flux asymmetry ({Phi}{sub n}{minus}{Phi}{sub d})/ {Phi}{sub average} is 0.033{+-}0.022(stat){sup +0.013}{sub {minus}0.012}(syst) . The recoil electron energy spectrum is consistent with no spectral distortion. For the hep neutrino flux, we set a 90% C.L.upper limit of 40{times}10{sup 3} cm{sup {minus}2}s{sup {minus}1} , which is 4.3times the BP2000 SSM prediction.

878 citations

Journal ArticleDOI
TL;DR: Results demonstrate that CYP707A family genes play a major regulatory role in controlling the level of ABA in plants.
Abstract: The hormonal action of abscisic acid (ABA) in plants is controlled by the precise balance between its biosynthesis and catabolism. In plants, ABA 8′-hydroxylation is thought to play a predominant role in ABA catabolism. ABA 8′-hydroxylase was shown to be a cytochrome P450 (P450); however, its corresponding gene had not been identified. Through phylogenetic and DNA microarray analyses during seed imbibition, the candidate genes for this enzyme were narrowed down from 272 Arabidopsis P450 genes. These candidate genes were functionally expressed in yeast to reveal that members of the CYP707A family, CYP707A1–CYP707A4, encode ABA 8′-hydroxylases. Expression analyses revealed that CYP707A2 is responsible for the rapid decrease in ABA level during seed imbibition. During drought stress conditions, all CYP707A genes were upregulated, and upon rehydration a significant increase in mRNA level was observed. Consistent with the expression analyses, cyp707a2 mutants exhibited hyperdormancy in seeds and accumulated six-fold greater ABA content than wild type. These results demonstrate that CYP707A family genes play a major regulatory role in controlling the level of ABA in plants.

875 citations

Journal ArticleDOI
TL;DR: The encouraging safety and clinical efficacy of nivolumab in patients with platinum-resistant ovarian cancer indicate the merit of additional large-scale investigations (UMIN Clinical Trials Registry UMIN000005714).
Abstract: Purpose Programmed death-1 (PD-1), a coinhibitory immune signal receptor expressed in T cells, binds to PD-1 ligand and regulates antitumor immunity. Nivolumab is an anti–PD-1 antibody that blocks PD-1 signaling. We assessed the safety and antitumor activity of nivolumab in patients with platinum-resistant ovarian cancer. Patients and Methods Twenty patients with platinum-resistant ovarian cancer were treated with an intravenous infusion of nivolumab every 2 weeks at a dose of 1 or 3 mg/kg (constituting two 10-patient cohorts) from October 21, 2011. This phase II trial defined the primary end point as the best overall response. Patients received up to six cycles (four doses per cycle) of nivolumab treatment or received doses until disease progression occurred. Twenty nivolumab-treated patients were evaluated at the end of the trial on December 7, 2014. Results Grade 3 or 4 treatment-related adverse events occurred in eight (40%) of 20 patients. Two patients had severe adverse events. In the 20 patients in...

875 citations


Authors

Showing all 86225 results

NameH-indexPapersCitations
Kari Alitalo174817114231
Ralph M. Steinman171453121518
Masayuki Yamamoto1711576123028
Karl Deisseroth160556101487
Kenji Kangawa1531117110059
Takashi Taniguchi1522141110658
Ben Zhong Tang1492007116294
Takeo Kanade147799103237
Yuji Matsuzawa143836116711
Tasuku Honjo14171288428
Kenneth M. Yamada13944672136
Y. B. Hsiung138125894278
Shuh Narumiya13759570183
Kevin P. Campbell13752160854
Junji Tojo13587884615
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023234
2022679
20218,533
20208,740
20198,050
20187,932