scispace - formally typeset
Search or ask a question
Institution

Kyungpook National University

EducationDaegu, South Korea
About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: A significant role is suggested in positively regulating osteoblast differentiation and bone formation in adult bone using the time‐ and site‐specific Cre/loxP system and no functional defects were found in osteoclasts.
Abstract: Osterix (Osx) is essential for osteoblast differentiation and bone formation, because mice lacking Osx die within 1 h of birth with a complete absence of intramembranous and endochondral bone formation. Perinatal lethality caused by the disruption of the Osx gene prevents studies of the role of Osx in bones that are growing or already formed. Here, the function of Osx was examined in adult bones using the time- and site-specific Cre/loxP system. Osx was inactivated in all osteoblasts by Col1a1-Cre with the activity of Cre recombinase under the control of the 2.3-kb collagen promoter. Even though no bone defects were observed in newborn mice, Osx inactivation with 2.3-kb Col1a1-Cre exhibited osteopenia phenotypes in growing mice. BMD and bone-forming rate were decreased in lumbar vertebra, and the cortical bone of the long bones was thinner and more porous with reduced bone length. The trabecular bones were increased, but they were immature or premature. The expression of early marker genes for osteoblast differentiation such as Runx2, osteopontin, and alkaline phosphatase was markedly increased, but the late marker gene, osteocalcin, was decreased. However, no functional defects were found in osteoclasts. In summary, Osx inactivation in growing bones delayed osteoblast maturation, causing an accumulation of immature osteoblasts and reducing osteoblast function for bone formation, without apparent defects in bone resorption. These findings suggest a significant role of Osx in positively regulating osteoblast differentiation and bone formation in adult bone.

176 citations

Journal ArticleDOI
TL;DR: In this paper, a model-independent search for a narrow resonance produced in proton-proton collisions at square root(s) = 8 TeV and decaying to a pair of 125 GeV Higgs bosons that in turn each decays into bottom quark-antiquark pairs is performed by the CMS experiment at the LHC.

176 citations

Journal ArticleDOI
TL;DR: In this article, the authors used model reduction (MR) schemes such as the mode superposition (MS), Ritz vector (RV), and quasi-static Ritz Vector (QSRV) to calculate dynamic responses and sensitivity values with adequate efficiency and accuracy for topology optimization in the frequency domain.

176 citations

Journal ArticleDOI
30 Oct 2006-Polymer
TL;DR: In this paper, a multiwalled carbon nanotube/polycaprolactone nanocomposites (MWNT/PCL) were prepared by in situ polymerization.

176 citations

Journal ArticleDOI
Wanqing Wen1, Wei Zheng1, Yukinori Okada2, Fumihiko Takeuchi, Yasuharu Tabara3, Joo-Yeon Hwang, Rajkumar Dorajoo4, Huaixing Li5, Fuu Jen Tsai6, Xiaobo Yang7, Jiang He8, Ying Wu9, Meian He10, Yi Zhang11, Jun Liang12, Xiuqing Guo13, Wayne Huey-Herng Sheu14, Ryan J. Delahanty1, Xingyi Guo1, Michiaki Kubo, Ken Yamamoto15, Takayoshi Ohkubo16, Min Jin Go, Jianjun Liu4, Wei Gan5, Ching-Chu Chen17, Yong Gao7, Shengxu Li8, Nanette R. Lee18, Chen Wu19, Xueya Zhou20, Huai-Dong Song11, Jie Yao13, I-Te Lee21, Jirong Long1, Tatsuhiko Tsunoda, Koichi Akiyama, Naoyuki Takashima16, Yoon Shin Cho22, Rick Th Ong4, Ling Lu5, Chien-Hsiun Chen23, Aihua Tan7, Treva Rice24, Linda S. Adair9, Lixuan Gui10, Matthew A. Allison, Wen-Jane Lee25, Qiuyin Cai1, Minoru Isomura26, Satoshi Umemura27, Young-Jin Kim, Mark Seielstad28, James E. Hixson29, Yong-Bing Xiang11, Masato Isono, Bong-Jo Kim, Xueling Sim30, Wei Lu31, Toru Nabika26, Juyoung Lee, Wei-Yen Lim, Yu-Tang Gao11, Ryoichi Takayanagi15, Daehee Kang32, Tien Yin Wong33, Chao A. Hsiung34, I-Chien Wu34, Jyh-Ming Jimmy Juang35, Jiajun Shi1, Bo Youl Choi36, Tin Aung33, Frank B. Hu37, Mi Kyung Kim36, Wei-Yen Lim, Tzung-Dao Wang35, Min-Ho Shin38, Jeannette Lee, Bu-Tian Ji, Young-Hoon Lee39, Terri L. Young30, Dong Hoon Shin40, Byung-Yeol Chun41, Myeong Chan Cho, Bok-Ghee Han, Chii-Min Hwu42, Themistocles L. Assimes43, Devin Absher, Xiaofei Yan13, Eric Kim13, Jane Z. Kuo44, Soonil Kwon13, Kent D. Taylor13, Yii-Der Ida Chen13, Jerome I. Rotter13, Lu Qi37, Dingliang Zhu11, Tangchun Wu10, Karen L. Mohlke9, Dongfeng Gu19, Zengnan Mo7, Jer-Yuarn Wu23, Xu Lin5, Tetsuro Miki45, E. Shyong Tai30, Jong-Young Lee, Norihiro Kato, Xiao-Ou Shu1, Toshihiro Tanaka2 
TL;DR: A meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals finds the association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.
Abstract: Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

176 citations


Authors

Showing all 20671 results

NameH-indexPapersCitations
Hyun-Chul Kim1764076183227
David R. Jacobs1651262113892
Yang Yang1642704144071
Yongsun Kim1562588145619
Jongmin Lee1502257134772
Inkyu Park1441767109433
Christopher George Tully1421843111669
Teruki Kamon1422034115633
Manfred Paulini1411791110930
Kazuhiko Hara1411956107697
Luca Lista1402044110645
Dong-Chul Son138137098686
Christoph Paus1371585100801
Frank Filthaut1351684103590
Andreas Warburton135157897496
Network Information
Related Institutions (5)
Korea University
82.4K papers, 1.8M citations

98% related

Seoul National University
138.7K papers, 3.7M citations

97% related

Chonnam National University
36.1K papers, 744.2K citations

97% related

Pusan National University
45K papers, 819.3K citations

97% related

Sungkyunkwan University
56.4K papers, 1.3M citations

97% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202375
2022317
20213,152
20203,071
20192,763
20182,664