Institution
Kyungpook National University
Education•Daegu, South Korea•
About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.
Topics: Population, Large Hadron Collider, Catalysis, Adsorption, Lepton
Papers published on a yearly basis
Papers
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TL;DR: A significant role is suggested in positively regulating osteoblast differentiation and bone formation in adult bone using the time‐ and site‐specific Cre/loxP system and no functional defects were found in osteoclasts.
Abstract: Osterix (Osx) is essential for osteoblast differentiation and bone formation, because mice lacking Osx die within 1 h of birth with a complete absence of intramembranous and endochondral bone formation. Perinatal lethality caused by the disruption of the Osx gene prevents studies of the role of Osx in bones that are growing or already formed. Here, the function of Osx was examined in adult bones using the time- and site-specific Cre/loxP system. Osx was inactivated in all osteoblasts by Col1a1-Cre with the activity of Cre recombinase under the control of the 2.3-kb collagen promoter. Even though no bone defects were observed in newborn mice, Osx inactivation with 2.3-kb Col1a1-Cre exhibited osteopenia phenotypes in growing mice. BMD and bone-forming rate were decreased in lumbar vertebra, and the cortical bone of the long bones was thinner and more porous with reduced bone length. The trabecular bones were increased, but they were immature or premature. The expression of early marker genes for osteoblast differentiation such as Runx2, osteopontin, and alkaline phosphatase was markedly increased, but the late marker gene, osteocalcin, was decreased. However, no functional defects were found in osteoclasts. In summary, Osx inactivation in growing bones delayed osteoblast maturation, causing an accumulation of immature osteoblasts and reducing osteoblast function for bone formation, without apparent defects in bone resorption. These findings suggest a significant role of Osx in positively regulating osteoblast differentiation and bone formation in adult bone.
176 citations
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Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2205 more•Institutions (182)
TL;DR: In this paper, a model-independent search for a narrow resonance produced in proton-proton collisions at square root(s) = 8 TeV and decaying to a pair of 125 GeV Higgs bosons that in turn each decays into bottom quark-antiquark pairs is performed by the CMS experiment at the LHC.
176 citations
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TL;DR: In this article, the authors used model reduction (MR) schemes such as the mode superposition (MS), Ritz vector (RV), and quasi-static Ritz Vector (QSRV) to calculate dynamic responses and sensitivity values with adequate efficiency and accuracy for topology optimization in the frequency domain.
176 citations
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TL;DR: In this paper, a multiwalled carbon nanotube/polycaprolactone nanocomposites (MWNT/PCL) were prepared by in situ polymerization.
176 citations
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Vanderbilt University1, Tokyo Medical and Dental University2, Kyoto University3, Agency for Science, Technology and Research4, Chinese Academy of Sciences5, Asia University (Taiwan)6, Guangxi Medical University7, Tulane University8, University of North Carolina at Chapel Hill9, Huazhong University of Science and Technology10, Shanghai Jiao Tong University11, Xuzhou Medical College12, Los Angeles Biomedical Research Institute13, National Defense Medical Center14, Kyushu University15, Shiga University of Medical Science16, China Medical University (Taiwan)17, University of San Carlos18, Peking Union Medical College19, Tsinghua University20, Chung Shan Medical University21, Hallym University22, Academia Sinica23, Washington University in St. Louis24, Tunghai University25, Shimane University26, Yokohama City University27, University of California, San Francisco28, University of Texas at Austin29, National University of Singapore30, Centers for Disease Control and Prevention31, New Generation University College32, Singapore National Eye Center33, National Health Research Institutes34, National Taiwan University35, Hanyang University36, Harvard University37, Chonnam National University38, Wonkwang University39, Keimyung University40, Kyungpook National University41, Taipei Veterans General Hospital42, Stanford University43, University of California, San Diego44, Ehime University45
TL;DR: A meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals finds the association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.
Abstract: Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
176 citations
Authors
Showing all 20671 results
Name | H-index | Papers | Citations |
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Hyun-Chul Kim | 176 | 4076 | 183227 |
David R. Jacobs | 165 | 1262 | 113892 |
Yang Yang | 164 | 2704 | 144071 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
Inkyu Park | 144 | 1767 | 109433 |
Christopher George Tully | 142 | 1843 | 111669 |
Teruki Kamon | 142 | 2034 | 115633 |
Manfred Paulini | 141 | 1791 | 110930 |
Kazuhiko Hara | 141 | 1956 | 107697 |
Luca Lista | 140 | 2044 | 110645 |
Dong-Chul Son | 138 | 1370 | 98686 |
Christoph Paus | 137 | 1585 | 100801 |
Frank Filthaut | 135 | 1684 | 103590 |
Andreas Warburton | 135 | 1578 | 97496 |