Kyungpook National University

About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.

Influence of calcium hydroxide intracanal medication on apical seal.

Abstract: Aim The aim of this study was to determine the influence of calcium hydroxide intracanal medication and various techniques for its removal on the sealing ability of gutta-percha root fillings with a zinc oxide-eugenol sealer. Methodology Eighty extracted mature human mandibular molar roots were divided into three groups of similar root-canal configuration. Calcium hydroxide paste was made by mixing calcium hydroxide powder with distilled water at a powder to liquid ratio of 1:1.25. After root canals were prepared and enlarged to a minimum of size 30 with the Profile 0.06 system, calcium hydroxide paste was placed in the canals of two groups, but no medication was placed in the control group. The intracanal calcium hydroxide was removed with two different techniques, 1 week after medication: K-files one size larger than the master apical file (MAF) were used with 2.5% NaOCl and 15% EDTA solutions in one group, whilst K-files the same size as the MAF were used with 2.5% NaOCl solution in another group. Canals were obturated with gutta-percha and Tubli-Seal cement using the lateral condensation technique. The apical sealing-ability was assessed by dye leakage and cross-sections of the specimens were examined under a stereomicroscope. The dye-penetration level was measured and analyzed using Fisher's exact test and Duncan's multiple range test. Results The calcium hydroxide-medicated groups showed significantly more dye leakage than the non-medicated control group (P 0.05). The stereomicroscopic views showed a relatively uneven and thicker layer of sealer in the calcium hydroxide-medicated groups. Conclusion Calcium hydroxide intracanal medication may increase apical leakage of gutta-percha root fillings when a zinc oxide-eugenol sealer is used.

Probiotics L. plantarum and L. curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet-Induced Obesity

Abstract: Objective: To determine the effects of naturally derived probiotic strains individually or combination on a short-term diet-induced obesity model. Design and Methods: C57BL/6J mice (n = 50) were randomly divided into five groups, then fed a high-fat high-cholesterol diet (HFCD), HFCD and Lactobacillus plantarum KY1032 (PL, 1010cfu/day), HFCD and Lactobacillus curvatus HY7601 (CU, 1010cfu/day), HFCD and in combination with PL+CU (1010cfu/day), or a normal diet (ND) for 9 weeks. Results: PL and CU showed distinct and shared metabolic activity against a panel of 50 carbohydrates. Fat accumulation in adipose tissue and liver was significantly reduced by probiotic strains CU or PL+CU. Probiotic strains CU or PL+CU reduced cholesterol in plasma and liver, while PL+CL had a synergistic effect on hepatic triglycerides. Probiotic strains PL+CU combination was more effective for inhibiting gene expressions of various fatty acid synthesis enzymes in the liver, concomitant with decreases in fatty acid oxidation-related enzyme activities and their gene expressions. Conclusions: Multi-strain probiotics may prove more beneficial than single-strain probiotics to combat fat accumulation and metabolic alterations in diet-induced obesity.

A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense.

Abstract: A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pancreatic β-cells. However, under pathological conditions, an imbalance in redox homeostasis leads to aberrant tissue damage and β-cell death due to a lack of antioxidant defense systems. Taking into account the vulnerability of islets to oxidative damage, induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed as a way to protect β-cells against diabetic insults. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions, as well as the therapeutic benefits of antioxidants, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with β-cell failure.

Combination of the top-quark mass measurements from the Tevatron collider

Abstract: We thank the Fermilab staff and technical staffs of the participating institutions for their vital contributions and acknowledge support from the DOE and NSF (USA), ARC (Australia), CNPq, FAPERJ, FAPESP, and FUNDUNESP (Brazil), NSERC (Canada), NSC, CAS, and CNSF (China), Colciencias (Colombia), MSMT and GACR (Czech Republic), the Academy of Finland, CEA, and CNRS/IN2P3 (France), BMBF and DFG (Germany), DAE and DST (India), SFI (Ireland), INFN (Italy), MEXT (Japan), the Korean World Class University Program and NRF (Korea), CONACyT (Mexico), FOM (Netherlands), MON, NRC KI, and RFBR (Russia), the Slovak R&D Agency, the Ministerio de Ciencia e Innovacio´n, and Programa Consolider-Ingenio 2010 (Spain), The Swedish Research Council (Sweden), SNSF (Switzerland), STFC and the Royal Society (United Kingdom), and the A. P. Sloan Foundation (USA).