Institution
Kyungpook National University
Education•Daegu, South Korea•
About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.
Topics: Population, Catalysis, Large Hadron Collider, Adsorption, Medicine
Papers published on a yearly basis
Papers
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TL;DR: In this article, the effects of Al doping and an annealing treatment on electrical and optical properties of ZnO thin films were investigated, and the optical transmittance of all films was higher than 80% in the visible range.
Abstract: Transparent conducting Al-doped ZnO thin films were prepared on silica glass substrates by an ultrasonic spray pyrolysis method. The effects of Al doping and an annealing treatment on electrical and optical properties of ZnO thin films were investigated. Zinc acetate dihydrate, 2-methoxyethanol and aluminum chloride were used as a starting material, a solvent and a dopant source, respectively. The electrical conductivity of ZnO films was improved by Al doping and by annealing in a reducing atmosphere. The minimum electrical resistivity was obtained in the 3 at.% Al-doped film annealed at 500 °C in nitrogen with 5% hydrogen and its value was 1.71×10−2 Ω cm. The average optical transmittance of all films, regardless of a doping concentration and an annealing condition, was higher than 80% in the visible range. The optical direct band gap of films was dependent on the amount of a dopant and the annealing treatment in a reducing atmosphere. The optical direct band gap value of 3 at.% Al-doped films annealed at 500 °C in nitrogen were 3.33 eV.
159 citations
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TL;DR: The results suggest that OMVs from A. baumannii are an important vehicle designed to deliver effector molecules to host cells, and several putative virulence-associated proteins were also identified.
Abstract: The secretion of outer membrane vesicles (OMVs) is one of the major mechanisms by which Gram-negative bacteria deliver effector molecules to host cells. Acinetobacter baumannii is an important opportunistic pathogen in hospital-acquired infections, but the secretion system for effector molecules to induce host cell damage has not been characterized. In the present study, we investigated the secretion of OMVs from a clinical A. baumannii isolate and analyzed the comprehensive proteome of A. baumannii-derived OMVs. Acinetobacter baumannii secreted OMVs into the extracellular milieu during in vitro growth. Using 1-DE and LC-MS/MS protein identification and assignment analysis, 132 different proteins associated with OMVs were identified. These proteins were derived from outer membranes (n=26), periplasmic space (n=6), inner membranes (n=8), cytoplasm (n=43), and unknown localization or multiple localization sites (n=49) according to the cell location prediction programs. Among the proteins associated with OMVs, a potent cytotoxic molecule, outer membrane protein A, was highly enriched and several putative virulence-associated proteins were also identified. These results suggest that OMVs from A. baumannii are an important vehicle designed to deliver effector molecules to host cells.
159 citations
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TL;DR: The Alpha Magnetic Spectrometer (AMS) is a precision particle physics detector on the International Space Station (ISS) conducting a unique, long-duration mission of fundamental physics research in space as mentioned in this paper.
159 citations
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TL;DR: MSC-EMs were successfully isolated using simple procedures and drug-loaded MSC- EMs were shown to be therapeutically efficient for the treatment of breast cancer both in vitro and in vivo.
Abstract: Exosomes derived from mesenchymal stem cells (MSCs) have been evaluated for their potential to be used as drug delivery vehicles. Synthetically personalized exosome mimetics (EMs) could be the alternative vesicles for drug delivery. In this study, we aimed to isolate EMs from human MSCs. Cells were mixed with paclitaxel (PTX) and PTX-loaded EMs (PTX-MSC-EMs) were isolated and evaluated for their anticancer effects against breast cancer. EMs were isolated from human bone marrow-derived MSCs. MSCs (4 × 106 cells/mL) were mixed with or without PTX at different concentrations in phosphate-buffered saline (PBS) and serially extruded through 10-, 5-, and 1-μm polycarbonate membrane filters using a mini-extruder. MSCs were centrifuged to remove debris and the supernatant was filtered through a 0.22-μm filter, followed by ultracentrifugation to isolate EMs and drug-loaded EMs. EMs without encapsulated drug (MSC-EMs) and those with encapsulated PTX (PTX-MSC-EMs) were characterized by western blotting, nanoparticle tracking analysis (NTA), and transmission electron microscopy (TEM). The anticancer effects of MSC-EMs and PTX-MSC-EMs were assessed with breast cancer (MDA-MB-231) cells both in vitro and in vivo using optical imaging. EMs were isolated by the extrusion method and ultracentrifugation. The isolated vesicles were positive for membrane markers (ALIX and CD63) and negative for golgi (GM130) and endoplasmic (calnexin) marker proteins. NTA revealed the size of MSC-EM to be around 149 nm, while TEM confirmed its morphology. PTX-MSC-EMs significantly (p < 0.05) decreased the viability of MDA-MB-231 cells in vitro at increasing concentrations of EM. The in vivo tumor growth was significantly inhibited by PTX-MSC-EMs as compared to control and/or MSC-EMs. Thus, MSC-EMs were successfully isolated using simple procedures and drug-loaded MSC-EMs were shown to be therapeutically efficient for the treatment of breast cancer both in vitro and in vivo. MSC-EMs may be used as drug delivery vehicles for breast cancers.
159 citations
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TL;DR: A novel gesture spotting method that combines gesture spotting with gesture recognition that recognizes the meaningful movements while concurrently separating unintentional movements from a given image sequence is proposed.
159 citations
Authors
Showing all 20671 results
Name | H-index | Papers | Citations |
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Hyun-Chul Kim | 176 | 4076 | 183227 |
David R. Jacobs | 165 | 1262 | 113892 |
Yang Yang | 164 | 2704 | 144071 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
Inkyu Park | 144 | 1767 | 109433 |
Christopher George Tully | 142 | 1843 | 111669 |
Teruki Kamon | 142 | 2034 | 115633 |
Manfred Paulini | 141 | 1791 | 110930 |
Kazuhiko Hara | 141 | 1956 | 107697 |
Luca Lista | 140 | 2044 | 110645 |
Dong-Chul Son | 138 | 1370 | 98686 |
Christoph Paus | 137 | 1585 | 100801 |
Frank Filthaut | 135 | 1684 | 103590 |
Andreas Warburton | 135 | 1578 | 97496 |